-
51.发明公开
公开(公告)号：KR1020050103691A
公开(公告)日：2005-11-01
申请号：KR1020040028968
申请日：2004-04-27
Applicant: 한국화학연구원
IPC: C12P41/00
Abstract: 본 발명은 리파제 효소촉매 하에 하기 화학식 1의 라세믹 알킬 락테이트를 카르보닐 공여체와 반응시켜 알킬
R -락테이트의 수산기만을 입체 선택적으로 카르보닐화하는 단계를 포함하는 알킬
S -(L)-락테이트 및/또는 알킬
R -(D)-O-아실락테이트의 제조방법으로, 본 발명은 기존의 방법에 비하여 수율 및 광학적 순도가 높은 알킬
S -(L)-락테이트 및 알킬
R -(D)-O-아실락테이트를 제조할 수 있으므로 산업적으로 유용하게 활용될 수 있다.
상기 화학식 1에서 R은 C
1 내지 C
10 의 포화 또는 불포화 알킬, 또는 알킬 치환된 아릴 또는 헤테로아릴을 의미한다.-
52.发明公开불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법 失效具有作为侧链的氟代乙烯醚类的抗菌腈化合物，其由于长时间剂量而引起的肝毒性降低，并且与口服毒性有关，并且与包含其的抗真菌组合物相比是稳定的
公开(公告)号：KR1020050017962A
公开(公告)日：2005-02-23
申请号：KR1020030055590
申请日：2003-08-12
Applicant: 한국화학연구원
IPC: C07D403/06
CPC classification number: C07D403/06 , C07D231/12 , C07D233/56 , C07D249/08
Abstract: PURPOSE: Antifungal azole compounds having fluorovinyl ether group as a side chain and an antifungal composition comprising the same compounds are provided, which compounds have improved antifungal activity, especially against antifungal agent resistant fungi, and improved stability in relation to human CytP450 3A4 enzyme, so that they can minimize liver toxicity due to the long time dosage, and also be stable in relation to the oral dosage toxicity. CONSTITUTION: The antifungal azole compounds having fluorovinyl ether group represented by formula (I) or pharmaceutically acceptable salts, isomers or ester compounds thereof are provided, wherein A is oxygen(-O-) or 4-(1,2,4-triazol-3-yl) phenylether, 4-(1,2,4-triazol-5-one-4-yl) phenylether, 4-(imidazol-2-one-3-yl) phenylether, or 4-(imidazolidine-2-one-3-yl) phenylether; R is hydrogen or trifluoromethy; R' is hydrogen or C1-4 alkyl; and X is hydrogen, halogen, C1-4 alkyl, haloalkyl, alkoxy or 3,4-dioxyalkylene ring. The antifungal composition comprises the antifungal azole compounds having fluorovinyl ether group represented by formula (I) and pharmaceutically acceptable carriers.
Abstract translation: 目的：提供具有氟乙烯基醚基作为侧链的抗真菌唑类化合物和包含相同化合物的抗真菌组合物，这些化合物具有改善的抗真菌活性，特别是抗真菌药物抗真菌，并且改善了与人类CytP450 3A4酶相关的稳定性。 它们可以由于长时间剂量而使肝毒性最小化，并且与口服剂量毒性相关也是稳定的。 构成：提供具有式（I）表示的氟乙烯基醚基的抗真菌唑化合物或其药学上可接受的盐，异构体或酯化合物，其中A是氧（-O-）或4-（1,2,4-三唑 - 苯基醚，4-（1,2,4-三唑-5-酮-4-基）苯基醚，4-（咪唑-2-酮-3-基）苯基醚或4-（咪唑烷-2-基） 苯基醚; R是氢或三氟甲基; R'是氢或C 1-4烷基; X为氢，卤素，C 1-4烷基，卤代烷基，烷氧基或3,4-二氧亚烷基环。 抗真菌组合物包含具有由式（I）表示的氟乙烯基醚基团和药学上可接受的载体的抗真菌唑类化合物。
-
-
公开(公告)号：KR1019940009934B1
公开(公告)日：1994-10-19
申请号：KR1019910005390
申请日：1991-04-03
Applicant: 한국화학연구원
IPC: C07C325/02
Abstract: New sterilized compound having a wide sterilizing effect and power is prepd. by: (A) synthesis of β-keto anilide of formula (II) from aniline; (B) synthesis of ketene dithio acetal α-anilide of formula (I) by reacting (II) and alkyl halide, dialkyl sulfate, alkyl alkyl or allyl sulfonate of formula (III) in the presence of CS2. In the formulas, R1, R2, R3, R4 are same or different, respectively hydrogen, aryl and aryl oxy and alkyl, alkenyl, alkoxy, thio alkyl, haloalkyl, nitro, cyano, aryl sulfonyl group; R5 is alkyl, hydrogen or halogen substituted aryl, group; R6 is alkyl or alkyl haloalkyl group.
Abstract translation: 具有广泛消毒效果和功效的新型灭菌化合物制备。 通过：（A）从苯胺合成式（II）的β-酮苯胺; （B）在CS2存在下，使式（I）的（II）和卤代烷基，硫酸二烷基酯，式（III）的烷基或烯丙基磺酸烷基酯反应合成式（I）的烯酮二硫代缩醛α-苯胺。 在式中，R 1，R 2，R 3，R 4分别相同或不同，分别为氢，芳基和芳氧基和烷基，烯基，烷氧基，硫代烷基，卤代烷基，硝基，氰基，芳基磺酰基; R5是烷基，氢或卤素取代的芳基，基团; R6是烷基或烷基卤代烷基。
-
Patent Agency Ranking
-
公开(公告)号：KR100069748B1
公开(公告)日：1994-01-11
申请号：KR1019910003227
申请日：1991-02-27
Applicant: 한국화학연구원
IPC: C07D233/66 , C07D233/80
-
公开(公告)号：KR1019930006772B1
公开(公告)日：1993-07-23
申请号：KR1019910003227
申请日：1991-02-27
Applicant: 한국화학연구원
IPC: C07D233/66 , C07D233/80
Abstract: 4-Acylimino-2-imidazolidinone derivs. of formula (I) are new. In (I), R1= substd. phenyl, pyridine, pyrazine, (un)saturated C1-4 alkyl or substd. benzene sulfonyl; R2= substd. alkyl, alkylamine, alkoxy or substd. phenyl; R3= substd. acetyl, substd. benzene sulfonyl or substd. benzoyl; R4 and R5 each = H, isopropyl, methyl, hexyl or phenyl. Also claimed is a herbicidal composition which contains 4-acylimino-2-imidazolidinone derivs. of formula (I).
Abstract translation: 4-酰基亚氨基-2-咪唑啉酮衍生物。 式（I）的化合物是新的。 在（I）中，R1 = 苯基，吡啶，吡嗪，（未）饱和C 1-4烷基或取代基。 苯磺酰; R2 = subd 烷基，烷基胺，烷氧基或取代基。 苯基; R3 = subd 乙酰基， 苯磺酰基或取代基。 苯甲酰; R4和R5各自为H，异丙基，甲基，己基或苯基。 还要求的是含有4-酰基亚氨基-2-咪唑烷酮衍生物的除草组合物。 的式（I）化合物。
-
公开(公告)号：KR1019910007886B1
公开(公告)日：1991-10-04
申请号：KR1019890006491
申请日：1989-05-15
Applicant: 한국화학연구원
IPC: C07D231/30 , C07D233/30
Abstract: Pyrazole sulfonate derivs. of formula (I) are prepd. by reacting 3-hydroxypyrazole de iv. of formula (II) with sulfonylhalide of formula R2SO2Y in an inert solvent in the presence of a base at 0-100 deg.C for 0.5-24hrs. In the formulas, R1=H, alkyl or benzyl; R2=alkylhaloalykyl, alkylphenyl or alkylamine; R3=alkyl or benzyl; n=0-2; X=hydroxy; Y=halogen. The pyrazole derivs. have a good insecticidal activity.
Abstract translation: 吡唑磺酸衍生物。 式（I）的化合物是制备的。 通过3-羟基吡唑 （II）化合物与式R 2 SO 2 Y的磺酰卤在惰性溶剂中，在0-100℃存在下反应0.5-24小时。 式中R1 = H，烷基或苄基; R2 =烷基卤代烷基，烷基苯基或烷基胺; R3 =烷基或苄基; N = 0-2; X =羟基; Y =卤素。 吡唑衍生物。 具有良好的杀虫活性。
-
-
-
-
-
-
-
-
Search Results
59
records
(took 0.024 seconds)
