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    ANTIFUNGAL FUSACANDINS
    51.
    发明申请
    ANTIFUNGAL FUSACANDINS 审中-公开
    抗真菌FUSACANDINS

    公开(公告)号：WO1996021670A2

    公开(公告)日：1996-07-18

    申请号：PCT/US1996000225

    申请日：1996-01-03

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ALDER, Lisa, A. ,  BURRES, Neal, S. ,  HOCHLOWSKI, Jill, E. ,  JACKSON, Marianna ,  McALPINE, James, B. ,  KLEIN, Larry, L. ,  LARTEY, Paul, A. ,  YEUNG, Clinton

    IPC: C07H15/10

    CPC classification number: C07H15/10 ,  A01N43/16

    Abstract: Novel antifungal agents having formula (I), wherein R is hydrogen or -C(O)-R1 wherein R1 is alkenyl, C2-C12-alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.

    Abstract translation: 具有式（I）的新型抗真菌剂，其中R是氢或-C（O）-R1，其中R 1是烯基，C 2 -C 12 - 烷基，芳基，芳基烯基，芳基烷基，芳基 - 芳基 - ，芳基烷氧基 - 芳基 - ，芳氧基 - 芳基 - ，芳基 - 芳基 - 芳基 - 或芳基烷氧基 - 芳基 - 芳基 - 或其药学上可接受的盐，酯或前药，以及（i）包含这些化合物的药物组合物，（ii）使用这些化合物的治疗方法， （iv）有用的方法和真菌培养物。

    LHRH ANTAGONISTS HAVING LACTAM GROUPS AT THE N-TERMINUS
    53.
    发明申请
    LHRH ANTAGONISTS HAVING LACTAM GROUPS AT THE N-TERMINUS 审中-公开
    在N末端有LACTAM组的LHRH拮抗剂

    公开(公告)号：WO1996017862A1

    公开(公告)日：1996-06-13

    申请号：PCT/US1995014488

    申请日：1995-11-08

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  SWENSON, Rolf, E. ,  HAVIV, Fortuna ,  MORT, Nicholas, A.

    IPC: C07K07/23

    CPC classification number: C07K7/23 ,  A61K38/00 ,  Y10S930/13

    Abstract: Peptides possessing LHRH antagonistic activity, and useful for controlling the release of LHRH in mammals are decapeptide analogues of LHRH having a lactam group at the N-terminus of formula (I), where n is 1, 2, or 3 and R is selected from the group consisting of hydrogen, benzyl, 4-chlorobenzyl, 2-methylnaphth-1-yl, 1-methylnaphth-2-yl, and quinolin-3-ylmethyl.

    Abstract translation: 具有LHRH拮抗活性并且可用于控制哺乳动物中LHRH释放的肽是在式（I）的N末端具有内酰胺基的LHRH的十肽类似物，其中n为1,2或3，R 1为 选自氢，苄基，4-氯苄基，2-甲基萘-1-基，1-甲基萘-2-基和喹啉-3-基甲基。

    VALVED INTRAVENOUS FLUID LINE CONNECTOR
    54.
    发明申请
    VALVED INTRAVENOUS FLUID LINE CONNECTOR 审中-公开
    阀门静脉流体线连接器

    公开(公告)号：WO1996017647A1

    公开(公告)日：1996-06-13

    申请号：PCT/US1995014887

    申请日：1995-11-15

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  CHOUDHURY, Hrishikesh ,  HELGREN, R., Hayes ,  VALENTINCIC, Charles, C.

    IPC: A61M39/04

    CPC classification number: A61M39/045 ,  Y10S604/905

    Abstract: A valve including a substantially ridig cannula and a valve member positioned for operable communication with the cannula. The valve member is formed from a substantially resilient material, having a slit extending therethrough, and movable with respect to the cannula between a first closed position and a second open position. The slit is substantially closed by the resiliency of the material of the valve member when the valve member is positioned in the first closed position and the cannula cooperates to extend through the slit during movement of the valve member from the first closed position to the second open position to establish a fluid flow path through the cannula and the valve member. A sealing member is also provided independant from a flow of fluid within the fluid flow path to provide positive sealing of the slit when the valve member is positioned in the first closed position.

    Abstract translation: 一种阀，包括一个基本上有齿的插管和一个定位成可与套管可操作连通的阀件。 阀构件由基本上弹性的材料形成，其具有穿过其延伸的狭缝，并且可相对于套管在第一关闭位置和第二打开位置之间移动。 当阀构件位于第一关闭位置时，狭缝基本上被阀构件的材料的弹性封闭，并且套管在阀构件从第一关闭位置运动到第二开口期间协同作用以延伸通过狭缝 以建立穿过套管和阀构件的流体流动路径。 当阀构件位于第一关闭位置时，也可以独立于流体流动路径内的流体流提供密封构件以提供狭缝的正密封。

    WINGED NEEDLE ASSEMBLY WITH PROTECTIVE MEMBER
    55.
    发明申请
    WINGED NEEDLE ASSEMBLY WITH PROTECTIVE MEMBER 审中-公开
    带有保护构件的双针组装

    公开(公告)号：WO1996017639A1

    公开(公告)日：1996-06-13

    申请号：PCT/US1995015078

    申请日：1995-11-17

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  FABOZZI, Richard, C.

    IPC: A61M05/32

    CPC classification number: A61M25/0637 ,  A61M5/3271 ,  A61M25/0631 ,  A61M2005/3228

    Abstract: This invention pertains to an intravenous infusion set and in particular, a winged needle assembly used for venipuncture having an integral hollow tubular protective member to reduce accidental needle sticks from such infusion set. The tubular member has a slot engagable by the wing on the rotatable hub and needle. Once aligned, the winged hub is pulled back into the slot and disengages at a lock-out position. The lateral notch retains the hub and needle within the tubular member.

    Abstract translation: 本发明涉及一种静脉输注装置，特别涉及一种用于静脉穿刺的翼形针组件，其具有一体的中空管状保护构件，以减少这种输注装置中的意外针刺。 管状构件具有可由可旋转轮毂和针上的机翼接合的槽。 一旦对准，翼形轮毂被拉回到槽中并在锁定位置脱离。 横向凹口将轮毂和针头保持在管状构件内。

    METHOD AND SYSTEM FOR STERILIZING HEAT SENSITIVE DRUGS
    56.
    发明申请
    METHOD AND SYSTEM FOR STERILIZING HEAT SENSITIVE DRUGS 审中-公开
    用于消除热敏感药物的方法和系统

    公开(公告)号：WO1996013279A1

    公开(公告)日：1996-05-09

    申请号：PCT/US1995013613

    申请日：1995-10-20

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  SZEMPRUCH, Walter, T.

    IPC: A61L02/04

    CPC classification number: A61L2/0023

    Abstract: A method and system for sterilizing heat sensitive drugs which prevent degradation of the drug from heat and its associated by-products where the method includes providing separate relatively less heat sensitive component solutions of the drug for independent heat sterilization and then transferring the sterilized component solutions to a holding tank where they are mixed to form a final solution constituting the desired drug thereby avoiding heating of the final solution or drug and its possible degradation.

    Abstract translation: 一种用于对热敏药物进行灭菌的方法和系统，其防止药物从热量及其相关副产物中降解，其中所述方法包括提供分开的相对较少的热敏组分溶液，用于独立热灭菌，然后将灭菌的组分溶液转移至 一个储存罐，在那里它们混合以形成构成所需药物的最终溶液，从而避免最终溶液或药物的加热及其可能的降解。

    OPTICAL WAVEGUIDE METHOD FOR DETECTING SPECIFIC BINDING EVENTS BY LIGHT SCATTERING
    59.
    发明申请
    OPTICAL WAVEGUIDE METHOD FOR DETECTING SPECIFIC BINDING EVENTS BY LIGHT SCATTERING 审中-公开
    用于通过光散射检测特定绑定事件的光波方法

    公开(公告)号：WO1996009532A1

    公开(公告)日：1996-03-28

    申请号：PCT/US1995011922

    申请日：1995-09-20

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  STIMPSON, Donald, I. ,  GORDON, Julian ,  HOIJER, Joanell, V.

    IPC: G01N21/77

    CPC classification number: G01N21/47 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00707 ,  C12Q1/6825 ,  C12Q1/6837 ,  G01N21/552 ,  G01N21/7703 ,  G01N33/54373 ,  C12Q2565/619 ,  C12Q2565/501 ,  C12Q2565/607

    Abstract: A waveguide binding assay method involves detecting the scattering of light directed into the waveguide, the scattering being the result of scattering labels specifically bound to the waveguide within the penetration depth of an evanescent wave. The waveguide may be transparent plastic or glass and the binding is typically by oligonucleotide hybridization or immunological capture. Light scattering labels include colloidal metals or non-metals, including gold, selenium and latex. A light absorbing member consisting of dye or concentrated particles may also be employed to enhance signal. Real-time binding and dissociation can be monitored visually or by video imaging, such as with a CCD camera and frame grabber software. Hybridization mismatches of as few as one base can be distinguished by real-time melting curves.

    Abstract translation: 波导结合测定方法包括检测引导到波导中的光的散射，散射是在ev逝波的穿透深度内特异地结合波导的散射标记的结果。 波导可以是透明塑料或玻璃，并且通常通过寡核苷酸杂交或免疫捕获来进行结合。 光散射标签包括胶体金属或非金属，包括金，硒和胶乳。 也可以使用由染料或浓缩颗粒组成的光吸收构件来增强信号。 可以通过视觉或视频成像来监视实时的绑定和解离，例如使用CCD相机和帧抓取软件。 通过实时熔解曲线可以区分少量一个碱基的杂交错配。

    PLASMA TREATMENT OF POLYMERIC MATERIALS TO ENHANCE IMMOBILIZATION OF ANALYTES THERETO
    60.
    发明申请
    PLASMA TREATMENT OF POLYMERIC MATERIALS TO ENHANCE IMMOBILIZATION OF ANALYTES THERETO 审中-公开
    聚合物材料的等离子体处理，以提高分析物的稳定性

    公开(公告)号：WO1995034814A1

    公开(公告)日：1995-12-21

    申请号：PCT/US1995007500

    申请日：1995-06-13

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  BLACK, William, N.

    IPC: G01N33/545

    CPC classification number: G01N33/545 ,  G01N33/54393

    Abstract: A method is disclosed for treating the surface of a polymeric material of an assay device to increase the sensitivity of diagnostic assays and screening assays. The method involves the treatment of the surface of the polymeric material with unseparated oxygen plasma to increase the binding capability of an analyte or analyte-binding member to such surface. The treated polymeric material is utilized as a diagnostic assay device or screening assay device for determining the amount or presence of an analyte or analyte-binding member in a test sample.

    Abstract translation: 公开了一种用于处理测定装置的聚合物材料的表面以增加诊断测定和筛选测定的灵敏度的方法。 该方法包括用未分离的氧等离子体处理聚合物材料的表面，以增加分析物或分析物结合构件对这种表面的结合能力。 经处理的聚合物材料用作诊断测定装置或筛选测定装置，用于确定测试样品中分析物或分析物结合成分的量或存在。

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