公开(公告)号：CL2021000972A1

公开(公告)日：2021-10-15

申请号：CL2021000972

申请日：2021-04-16

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BOYS MARK LAURENCE ,  CHICARELLI MARK JOSEPH ,  COOK ADAM ,  ELSAYED MOHAMED S A ,  FELL JAY B ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  MCNULTY OREN T ,  MEJIA MACEDONIO J ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E

IPC: A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D519/00

Abstract: Se proporcionan compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal farmacéuticamente aceptable del mismo, útiles para el tratamiento de enfermedades hiperproliferativas. Se describen métodos para utilizar los compuestos de la Fórmula I o un estereoisómero, tautómero, profármaco o sal farmacéuticamente aceptable del mismo, para su diagnóstico, prevención o tratamiento in vitro, in situ e in vivo, de tales trastornos en células de mamífero o padecimientos asociados.

公开(公告)号：AU2020251841A1

公开(公告)日：2021-10-07

申请号：AU2020251841

申请日：2020-03-30

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BOYS MARK LAURENCE ,  CHICARELLI MARK JOSEPH ,  COOK ADAM W ,  ELSAYED MOHAMED S A ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  JIANG YUTONG ,  MCNULTY OREN T ,  MEJIA MACEDONIO J ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E

IPC: C07D401/14 ,  A61K31/53 ,  A61P35/00 ,  C07D403/04 ,  C07D451/04 ,  C07D471/10 ,  C07D491/107 ,  C07D513/10 ,  C07D519/00

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for

公开(公告)号：CR20210189A

公开(公告)日：2021-09-14

申请号：CR20210189

申请日：2019-10-17

Applicant: ARRAY BIOPHARMA INC

Inventor： CHICARELLI MARK JOSEPH ,  MCNULTY OREN T ,  COOK ADAM ,  ELSAYED MOHAMED S A ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E ,  BOYS MARK LAURENCE ,  FISCHER JOHN P ,  BLAKE JAMES F ,  FELL JAY B ,  HINKLIN RONALD JAY ,  MEJIA MACEDONIO J

IPC: A61K31/4985 ,  A61K31/498 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D519/00

Abstract: Se proporcionan compuestos de la Formula I o un estereoisomero, tautomero, profarmaco o sal farmaceuticamente aceptable del mismo, los cuales son utiles para el tratamiento de enfermedades hiperproliferativas. Se describen metodos para utilizar los compuestos de la Formula I o un estereoisomero, 5 tautomero, profarmaco o sal farmaceuticamente aceptable del mismo, para su diagnostico, prevencion o tratamiento in vitro , in situ e in vivo , de tales trastornos en celulas de mamifero o padecimientos asociados.

公开(公告)号：SG11202102985YA

公开(公告)日：2021-05-28

申请号：SG11202102985Y

申请日：2019-10-17

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BOYS MARK LAURENCE ,  CHICARELLI MARK JOSEPH ,  COOK ADAM ,  ELSAYED MOHAMED S A ,  FELL JAY B ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  MCNULTY OREN T ,  MEJIA MACEDONIO J ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E

IPC: C07D401/04 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed

公开(公告)号：CA3148745A1

公开(公告)日：2021-03-04

申请号：CA3148745

申请日：2020-08-27

Applicant: MIRATI THERAPEUTICS INC ,  ARRAY BIOPHARMA INC

Inventor： WANG XIAOLUN ,  CHRISTENSEN JAMES GAIL ,  KETCHAM JOHN MICHAEL ,  MARX MATTHEW ARNOLD ,  SMITH CHRISTOPHER RONALD ,  ALLEN SHELLEY ,  DAI DONGHUA ,  FISCHER JOHN PETER ,  NEWHOUSE BRAD ,  O'LEARY JACOB MATTHEW ,  RODRIGUEZ MARTHA E ,  VIGERS GUY P A ,  ZHAO QIAN ,  GAUDINO JOHN ,  BURNS AARON CRAIG ,  LAWSON JOHN DAVID ,  BLAKE JAMES FRANCIS ,  CHICARELLI MARK JOSEPH ,  DAHLKE JOSHUA RYAN ,  FELL JAY BRADFORD ,  MEJIA MACEDONIO J ,  NGUYEN PHONG ,  PAJK SPENCER ,  SAVECHENKOV PAVEL ,  TANG TONY P ,  KAHN DEAN RUSSELL ,  GAUDINO JOHN ,  HILTON MICHAEL CHRISTOPHER

IPC: A61K31/435 ,  A61K31/4375 ,  A61K31/517 ,  C07D471/00 ,  C07D471/02 ,  C07D471/04

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

公开(公告)号：CA2785338C

公开(公告)日：2018-09-18

申请号：CA2785338

申请日：2010-12-20

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D519/00

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain. (see formula I)

公开(公告)号：AU2018201903A1

公开(公告)日：2018-04-12

申请号：AU2018201903

申请日：2018-03-16

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: [007801 Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R', R2, R, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：AU2016222468B2

公开(公告)日：2017-12-21

申请号：AU2016222468

申请日：2016-09-02

Applicant: ARRAY BIOPHARMA INC

Inventor： ZHAO QIAN ,  NEWHOUSE BRAD ,  DELISLE ROBERT KIRK ,  RAST BRYSON ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  TOPALOV GEORGE T ,  RIZZI JAMES P ,  BOYS MARK LAURENCE ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  RODRIGUEZ MARTHA E

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2 , R3 , R4, R' and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：PL2651939T3

公开(公告)日：2015-10-30

申请号：PL11808427

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：SMT201500165B

公开(公告)日：2015-09-07

申请号：SM201500165

申请日：2015-07-08

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  KENNEDY APRIL L ,  MUNSON MARK C ,  RAST BRYSON ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN ,  HICKEN ERIK JAMES ,  MARMSATER FREDRIK P ,  MARESKA DAVIDE A ,  NEWHOUSE BRAD ,  RIZZI JAMES P

Abstract: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.