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公开(公告)号：DE102005018465A1
公开(公告)日：2006-11-02
申请号：DE102005018465
申请日：2005-04-20
Applicant: BASF AG
Inventor： KOLTER KARL , ASCHERL HERMANN , FUSSNEGGER BERNHARD
Abstract: Purify-hasty, powdered bonding agents comprises a vinyllactampolymer, where the bonding agents exhibits an average particle size of upto 35 mu m and a bulk density of smaller than 0.2 g/ml. Independent claims are included for: (1) use of the bonding agent for production of tablets with high firmness; and (2) the preparation of the bonding agents.
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公开(公告)号：DE102005005974A1
公开(公告)日：2006-08-10
申请号：DE102005005974
申请日：2005-02-09
Applicant: BASF AG
Inventor： KOLTER KARL , GARCIA CASTRO IVETTE , PINNEKER OLGA , WIDMAIER RALF , STRUBE KARL-HERMANN , FUSSNEGGER BERNHARD , KROLL MANFRED , HOEFER FRANK , ASCHERL HERMANN , SCHMIDT PETER
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公开(公告)号：DE50109662D1
公开(公告)日：2006-06-08
申请号：DE50109662
申请日：2001-03-06
Applicant: BASF AG
Inventor： KOLTER KARL DR , SCHOENHERR MICHAEL DR , ASCHERL HERMANN
IPC: A61K9/22 , A61K9/00 , A61K9/20 , A61K9/52 , A61K31/5513 , A61K45/00 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/36 , A61K47/38
Abstract: Sustained-release oral dosage form that floats in gastric fluid comprises: (1) one or more active ingredients; (2) a blend of polyvinyl acetate (PVAc) and polyvinylpyrrolidone (PVP); and optionally (3) excipients. An independent claim is also included for production of the dosage form by compression at a pressure below 100 MPa.
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公开(公告)号：ES2236086T3
公开(公告)日：2005-07-16
申请号：ES01111614
申请日：2001-05-12
Applicant: BASF AG
Inventor： KOLTER KARL DR , FLICK DIETER , ASCHERL HERMANN
IPC: A61K47/32 , A61K9/16 , A61K9/20 , A61K9/22 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61P3/02
Abstract: Procedimiento para la obtención de una forma de administración oral o liberación de producto activo retardada, que contiene a) una mezcla formulada de acetato de polivinilo y polivinilpirrolidona, b) al menos un producto activo, c) en caso dado polímeros hidrosolubles o aditivos lipófilos de peso molecular reducido o elevado, d) así como, en caso dado, otras substancias auxiliares habituales, caracterizado porque la proporción de acetato de polivinilo respecto a polivinilpirrolidona asciende a 6 : 4 hasta 9 : 1, acetato de polivinilo y polivinilpirrolidona presentan respectivamente un peso molecular de 20.000 a 1.000.000, y el granulado de la mezcla de a) a d) o a) a c) o a) y b) y d) o a) y b) se efectúa sin adición de disolvente mediante calentamiento a 40ºC hasta 130ºC.
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Patent Agency Ranking
公开(公告)号：AT288259T
公开(公告)日：2005-02-15
申请号：AT01111614
申请日：2001-05-12
Applicant: BASF AG
Inventor： KOLTER KARL DR , FLICK DIETER , ASCHERL HERMANN
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公开(公告)号：DE10315671A1
公开(公告)日：2004-10-14
申请号：DE10315671
申请日：2003-04-04
Applicant: BASF AG
Inventor： BERTLEIN GERHARD , SCHALL KARL HEINZ , MAASE MATTHIAS , HEILEK JOERG , BAUMANN DIETER , ASCHERL HERMANN
IPC: C07F9/53
Abstract: The present invention relates to a process for the preparation of solid acylphosphine oxides by converting an acylphosphine oxide which is in the form of a melt or in dispersed form into the solid state of aggregation with mechanical stress, shearing/internal agitation of the melt.
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公开(公告)号：NO20015465L
公开(公告)日：2001-11-09
申请号：NO20015465
申请日：2001-11-08
Applicant: BASF AG
Inventor： SCHAEFER BERND , HARMS GUIDO , ASCHERL HERMANN , KREI GEORG ARNOLD
IPC: C12N9/99 , A61K38/00 , A61P7/02 , A61P9/00 , A61P25/00 , A61P35/00 , C07K5/065 , C07K1/14 , A61K38/05
Abstract: The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula Iwhere n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried.
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公开(公告)号：CA2373068A1
公开(公告)日：2000-11-16
申请号：CA2373068
申请日：2000-05-03
Applicant: BASF AG
Inventor： KREI GEORG ARNOLD , ASCHERL HERMANN , SCHAFER BERND , HARMS GUIDO
IPC: C12N9/99 , A61K38/00 , A61P7/02 , A61P9/00 , A61P25/00 , A61P35/00 , C07K5/065 , C07K5/06 , C07K1/14 , A61K31/40 , A61K31/44
Abstract: The invention relates to a method for producing thrombin inhibitors which ha ve a constant weight and which are of formula (I), whereby n represents 0, 1, 2 and tautomers thereof, whereby an aqueous solution of the active substance i s spray dried.
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公开(公告)号：DE19649681A1
公开(公告)日：1998-06-04
申请号：DE19649681
申请日：1996-11-29
Applicant: BASF AG
Inventor： SCHOENHERR MICHAEL DR , RAULS MATTHIAS DR , ASCHERL HERMANN , LETZELTER THOMAS , BAUMANN DIETER , POTTHOFF-KARL BIRGIT DR
IPC: C11D1/04 , C07C227/42 , C07C229/16 , C07C229/24 , C07C229/22 , C11D3/33
Abstract: A method for the preparation of a crystalline solid comprising a glycine-N,N-diacetic acid derivative of formula (I) with a very low hygroscopicity, comprises fixing the water content of the starting material containing (I) at 10-30 wt.% and then carrying out crystallisation: MOOC-CH(R)-N(CH2COOM)2 (I) R = 1-30C alkyl or 2-30C alkenyl (both optionally containing 1-5 OH, formyl, 1-4C alkoxy(carbonyl) or phenoxy groups and/or optionally containing up to 5 non-adjacent O atoms in the chain), alkoxylate groups of formula (II), phenyl-(1-20 C)-alkyl (optionally containing up to 3 1-4C alkyl, OH, carboxyl, sulpho or 1-4C alkoxycarbonyl ring substituents), 5- or 6-membered optionally benzalated heterocyclic ring containing up to 3 N, O or S atoms (optionally containing up to 3 1-4C alkyl, OH, carboxyl, sulpho or 1-4C alkoxycarbonyl substituents) or a group of formula (III): -(CH2)k-O-(A O)m-(A O)n-Y (II) -A-CH(COOM)-N(CH2COOM)2 (III) A , A = 2-4C 1,2-alkylene; Y = H, 1-12C alkyl, phenyl or 1-4C alkoxycarbonyl; k = 1-3; m, n = 0-50; A = 1-12C alkylene or single bond; and M = H, alkali(ne earth) metal or optionally substituted ammonium, with the provision that m+n = at least 4.
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