公开(公告)号：DE59207735D1

公开(公告)日：1997-01-30

申请号：DE59207735

申请日：1992-09-21

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  KUENAST CHRISTOPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

公开(公告)号：ZA9502614B

公开(公告)日：1996-09-30

申请号：ZA9502614

申请日：1995-03-30

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/53

公开(公告)号：CA2195243A1

公开(公告)日：1996-02-01

申请号：CA2195243

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to triazole compounds of formula (I) in which R1, R2 stand for H or different substituents, A stands for a bivalent group, B stands for a rest of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.

公开(公告)号：CA2195241A1

公开(公告)日：1996-02-01

申请号：CA2195241

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The use is disclosed of pyrimidine compounds having the formula (I), in which R1, R2, R3, A, B and Ar have the meanings given in the description. These compounds have a high affinity for the dopamine D3 receptor and are therefore useful for treating diseases that respond to dopamine D3 ligands.

公开(公告)号：AT119571T

公开(公告)日：1995-03-15

申请号：AT90917037

申请日：1990-11-22

Applicant: BASF AG

Inventor： MEYER THOMAS ,  FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED

IPC: A61K35/62 ,  A61K38/00 ,  C12N9/48

公开(公告)号：CA2121134A1

公开(公告)日：1993-06-29

申请号：CA2121134

申请日：1992-09-21

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  BIALOJAN SIEGFRIED ,  KUENAST CHRISTOPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19 ,  A61K38/57

Abstract: 2121134 9308282 PCTABS00021 Described is a new thrombin-inhibiting protein isolated from ticks, with a molecular weight of about 8000 Daltons and the N-terminus Leu-Asn-Val-Leu-Cys-Asn-Asn-Pro-His-Thr-Ala-Asp-Cys-Asn-Asn-Asp-Ala-Gln-Val-A_ sp. The protein is suitable for use in the treatment of illnesses.

公开(公告)号：MX9206055A

公开(公告)日：1993-04-01

申请号：MX9206055

申请日：1992-10-21

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  KROEGER BRUKHARD ,  BIALOJAN SIEGFRIED

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/14 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C07K15/00

Abstract: PCT No. PCT/EP92/02198 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Sep. 23, 1992 PCT Pub. No. WO93/09231 PCT Pub. Date May 13, 1993A novel thrombin inhibitory protein from ticks with a molecular weight of about 26000 dalton and the partial amino acid sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly (SEQ ID NO: 8), His-Ala-Y-Phe-Glu (SEQ ID NO: 3), Arg-Val-Ser-Asp-Phe-Glu (SEQ ID NO: 4), Phe-Val-Tyr-Thr-Ile-Glu (SEQ ID NO: 6), where X and Y can be identical or different and each is a naturally occurring amino acid, is suitable for controlling diseases.

公开(公告)号：CA2093432A1

公开(公告)日：1992-04-07

申请号：CA2093432

申请日：1991-09-27

Applicant: BASF AG

Inventor： STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED

IPC: A61K38/00 ,  A61P7/02 ,  C07K14/435 ,  C07K14/815

Abstract: 2093432 9206118 PCTABS00011 Described is a new protein, suitable for use in the treatment of illnesses, produced from Hirudo medicinalis. The protein extends the clotting time of blood, is relatively stable to heat and has a molecular weight of 25-34 KDa. Also described are the muteins of the new protein.

公开(公告)号：CA2195243C

公开(公告)日：2006-05-30

申请号：CA2195243

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  DRESCHER KARLA ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  BIALOJAN SIEGFRIED ,  MUNSCHAUER RAINER ,  UNGER LILIANE

IPC: C07D249/08 ,  C07D403/12 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relate to triazole compounds of formula (I) in which R 1, R2 stand for H or different substituents, A stands for a bivalent group, B stands for a test of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of disease responding to dopamine-D3-ligands.

公开(公告)号：PT752854E

公开(公告)日：2002-02-28

申请号：PT95914301

申请日：1995-03-23

Applicant: BASF AG

Inventor： UNGER LILIANE ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  KLINGE DAGMAR ,  RASCHACK MANFRED ,  BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  WERNET WOLFGANG

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  C07D251/26 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I