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    Process for the production of solid pharmaceutical sustained release forms
    53.
    发明专利
    Process for the production of solid pharmaceutical sustained release forms 未知

    公开(公告)号：DE3810343A1

    公开(公告)日：1989-10-05

    申请号：DE3810343

    申请日：1988-03-26

    Applicant: BASF AG

    Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER DR ,  LANG SIEGFRIED DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR ,  SCHLEMMER LOTHAR

    IPC: A61K9/20 ,  A61K9/22

    Abstract: Process for the production of solid pharmaceutical sustained release forms which contain as binder a polymer which dissolves or disperses in water and gastric or intestinal fluid, wherein the pharmaceutical agent, the polymeric binder and, where appropriate, the pharmaceutical ancillary substances are mixed below the glass transition temperature of the binder, this mixture is compressed, above the glass transition temperature of the binder but below the decomposition temperature of the agent, to pharmaceutical forms, and the form is removed from the mould at a temperature below the glass transition temperature of the binder, and where the type and amount of the binder and ancillary substance are chosen so that the release of agent is sustained for a period of 3 to 24 hours.

    54.
    发明专利
    未知

    公开(公告)号：DE3807235A1

    公开(公告)日：1989-09-14

    申请号：DE3807235

    申请日：1988-03-05

    Applicant: BASF AG

    Inventor： AYDIN ORAL DR ,  FICKEISEN PETER ,  HUMMERICH RAINER DR ,  GOERTZ HANS-HELMUT DR

    IPC: E04F13/21 ,  C04B24/32 ,  C08G65/26 ,  C08L71/00 ,  C08L71/02 ,  C09J11/08 ,  C09J157/00 ,  C09J171/00 ,  C09J171/02 ,  C09K3/00

    Abstract: Laying of tiles by means of a tile adhesive based on a polymer emulsion and customary additives, containing a compound of the general formula I as thickener where R = a radical of a 2- to 6-hydric alcohol of from 2 to 10 carbon atoms, attached by oxygen, R = an alkyl, alkoxymethyl or alkenyloxymethyl radical or a mixture of these radicals, each having from 16 to 30 carbon atoms in the alkyl, alkoxy or alkenyloxy radical, A = -CH2CH2-O- (=EO) alone or mixed with where at least 50 mol %, preferably at least 70 mol % of A is -CH2CH2O-, x = 12 to 500, y = an average (averaged over numerous molecules) from 0.3 to 5, preferably from 0.5 to 2, n = an integer from 2 to 6.

    58.
    发明专利
    未知

    公开(公告)号：ES2098081T3

    公开(公告)日：1997-04-16

    申请号：ES94111341

    申请日：1994-07-21

    Applicant: BASF AG

    Inventor： LUX MARTIN DR ,  FUNK GUIDO DR ,  SAIVE ROLAND DR ,  GOERTZ HANS-HELMUT DR ,  KONRAD RAINER DR

    IPC: C09K3/16 ,  C08F2/34 ,  C08F2/44 ,  C08F10/00 ,  C08F10/02 ,  C08F110/02 ,  C08K5/17 ,  C08K5/20 ,  C08L23/02

    Abstract: A process for the preparation of homopolymers of ethylene or copolymers of ethylene with secondary amounts of other C3- to C12-alk-1-enes by catalytic polymerisation in a suspension or in the gas phase in the presence of an antistatic at a temperature of from 50 to 120 DEG C and at a pressure of from 5 to 50 bar, characterised in that the antistatic employed is a mixture of the following substances: a) a metal salt of medialanic acid of formula (I) , b) a metal salt of an anthranilic acid of formula (II) , where the organic radical R is either alpha ) -CO-(CH2)x-CH3 (III alpha ) or ss) -CO-(CH2)y-CH=CH-(CH2)z-CH3 (IIIss), where x, y and z are each an integer, and x is in the range from 6 to 18, y is in the range from 1 to 16, z is in the range from 1 to 16 and y + z is in the range from 4 to 17, and c) a polyamine obtainable by reacting epichlorohydrin with an aliphatic primary monoamine or an N-alkylalkylenediamine of the formula (IV> R NH-R -NH2 (IV), where R is a C8-C24-alkyl radical and R is a C2-C6-alkylene radical. d

    59.
    发明专利
    未知

    公开(公告)号：DE59401850D1

    公开(公告)日：1997-04-03

    申请号：DE59401850

    申请日：1994-07-21

    Applicant: BASF AG

    Inventor： LUX MARTIN DR ,  FUNK GUIDO DR ,  SAIVE ROLAND DR ,  GOERTZ HANS-HELMUT DR ,  KONRAD RAINER DR

    IPC: C09K3/16 ,  C08F2/34 ,  C08F2/44 ,  C08F10/00 ,  C08F10/02 ,  C08F110/02 ,  C08K5/17 ,  C08K5/20 ,  C08L23/02

    Abstract: A process for the preparation of homopolymers of ethylene or copolymers of ethylene with secondary amounts of other C3- to C12-alk-1-enes by catalytic polymerisation in a suspension or in the gas phase in the presence of an antistatic at a temperature of from 50 to 120 DEG C and at a pressure of from 5 to 50 bar, characterised in that the antistatic employed is a mixture of the following substances: a) a metal salt of medialanic acid of formula (I) , b) a metal salt of an anthranilic acid of formula (II) , where the organic radical R is either alpha ) -CO-(CH2)x-CH3 (III alpha ) or ss) -CO-(CH2)y-CH=CH-(CH2)z-CH3 (IIIss), where x, y and z are each an integer, and x is in the range from 6 to 18, y is in the range from 1 to 16, z is in the range from 1 to 16 and y + z is in the range from 4 to 17, and c) a polyamine obtainable by reacting epichlorohydrin with an aliphatic primary monoamine or an N-alkylalkylenediamine of the formula (IV> R NH-R -NH2 (IV), where R is a C8-C24-alkyl radical and R is a C2-C6-alkylene radical. d

    60.
    发明专利
    未知

    公开(公告)号：AT149183T

    公开(公告)日：1997-03-15

    申请号：AT94111341

    申请日：1994-07-21

    Applicant: BASF AG

    Inventor： LUX MARTIN DR ,  FUNK GUIDO DR ,  SAIVE ROLAND DR ,  GOERTZ HANS-HELMUT DR ,  KONRAD RAINER DR

    IPC: C09K3/16 ,  C08F2/34 ,  C08F2/44 ,  C08F10/00 ,  C08F10/02 ,  C08F110/02 ,  C08K5/17 ,  C08K5/20 ,  C08L23/02

    Abstract: A process for the preparation of homopolymers of ethylene or copolymers of ethylene with secondary amounts of other C3- to C12-alk-1-enes by catalytic polymerisation in a suspension or in the gas phase in the presence of an antistatic at a temperature of from 50 to 120 DEG C and at a pressure of from 5 to 50 bar, characterised in that the antistatic employed is a mixture of the following substances: a) a metal salt of medialanic acid of formula (I) , b) a metal salt of an anthranilic acid of formula (II) , where the organic radical R is either alpha ) -CO-(CH2)x-CH3 (III alpha ) or ss) -CO-(CH2)y-CH=CH-(CH2)z-CH3 (IIIss), where x, y and z are each an integer, and x is in the range from 6 to 18, y is in the range from 1 to 16, z is in the range from 1 to 16 and y + z is in the range from 4 to 17, and c) a polyamine obtainable by reacting epichlorohydrin with an aliphatic primary monoamine or an N-alkylalkylenediamine of the formula (IV> R NH-R -NH2 (IV), where R is a C8-C24-alkyl radical and R is a C2-C6-alkylene radical. d

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