公开(公告)号：AU2012276691A1

公开(公告)日：2013-12-12

申请号：AU2012276691

申请日：2012-06-28

Applicant: KANEKA CORP

Inventor： MOURI TAKU ,  TAOKA NAOAKI ,  MOROSHIMA TADASHI ,  KINOSHITA KOICHI

IPC: C07K5/093 ,  A23L1/305 ,  A61K8/64 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K38/00 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61P39/02 ,  C07K5/037

Abstract: A solid oxidized glutathione salt is produced by heating oxidized glutathione to at least 30°C while bringing the oxidized glutathione into contact with an aqueous medium composed of water and/or a water-soluble medium, in the presence of a substance capable of generating at least one type of cation selected from ammonium cations, calcium cations, and magnesium cations, so as to produce a salt of the oxidized glutathione and the cation as a solid.

公开(公告)号：AT346086T

公开(公告)日：2006-12-15

申请号：AT99944783

申请日：1999-09-22

Applicant: KANEKA CORP

Inventor： MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07K5/068 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/06

Abstract: The process for producing N -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline in a simple, efficient and industrially advantageous manner, which comprises: the first step of subjecting the N -(1(S)-alkoxycarbonyl-3-phenylpropyl)-N -trifluoroacetyl-L-lysyl -L-proline (1) to alkali hydrolysis in a mixed solution composed of water and a hydrophilic organic solvent using an inorganic base in an amount of n molar equivalents (n >/= 3) per mole of the above compound (1), the second step of neutralizing the hydrolysis product using an inorganic acid in an amount of (n - 1) to n molar equivalents (n >/= 3) and removing the inorganic salt formed by causing the same to precipitate out from a solvent system suited for decreasing the solubility of the inorganic salt, and the third step of causing the compound (2) existing in the mixture after removal of the inorganic salt to crystallize out at the isoelectric point thereof and thereby recovering the compound (2) in the form of crystals while retaining the salts comprising the trifluoroacetic acid-derived organic acid salt in a state dissolved in the mother liquor.

公开(公告)号：DE69830307T2

公开(公告)日：2006-02-02

申请号：DE69830307

申请日：1998-07-21

Applicant: KANEKA CORP

Inventor： UEDA YASUYOSHI ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE

IPC: A61P9/12 ,  C07K1/02 ,  C07K1/08 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062

Abstract: Preparation of salts of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl amino acid derivatives of formula (R1)NH-CH(R2)-CO2H (I) comprises: (a) condensing an amino acid with N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxyanhydride of formula (II), under basic conditions; (b) decarboxylating the condensate under neutral to acidic conditions to give (I); and (c) and converting (I) to its salt. Steps (a), (b) and optionally (c) are carried out in aqueous liquid to inhibit the formation of by-products of formula (III): -N(R1)CH(R2)-C(O)- = e.g. group of formula (i).

公开(公告)号：DE69722111D1

公开(公告)日：2003-06-26

申请号：DE69722111

申请日：1997-01-29

Applicant: KANEKA CORP

Inventor： SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI ,  KAN KAZUNORI

IPC: C07B41/02 ,  C07B53/00 ,  C07C29/143 ,  C07C213/00 ,  C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C319/20 ,  C07C323/43 ,  C07C33/22 ,  C07C215/28 ,  C07C271/10

Abstract: The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing alpha -aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formual (4) to provide the corresponding alcohol compound of the general formula (5).

公开(公告)号：DE69716452T2

公开(公告)日：2003-06-26

申请号：DE69716452

申请日：1997-08-18

Applicant: KANEKA CORP

Inventor： MATSUMOTO SHINGO ,  MATSUO KAZUHIKO ,  SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI

IPC: C07C227/02 ,  C07C227/42 ,  C07C229/22 ,  C07C229/34 ,  C07C229/36 ,  C07C269/08 ,  C07C271/18 ,  C07C271/22 ,  C07C303/40 ,  C07C303/44 ,  C07C311/19 ,  C07D209/26 ,  C07D209/48

Abstract: An object of the present invention is to provide a process for producing a beta -amino- alpha -hydroxy acid derivative via efficient and industrially utilizable steps. The present invention provides a process for producing a beta -amino- alpha -hydroxy acid derivative represented by the general formula (2) given below which comprises hydrolyzing an alpha -amino- alpha ', alpha '-dihaloketone derivative of the general formula (1) given below in the presence of a base, followed by protecting the amino group or without protecting the same.

公开(公告)号：IN190128B

公开(公告)日：2003-06-14

申请号：IN173CA1997

申请日：1997-01-29

Applicant: KANEKA CORP

Inventor： SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI ,  KAN KAZUNORI

IPC: C07C29/136 ,  C07C31/36

公开(公告)号：IN187670B

公开(公告)日：2002-06-01

申请号：IN796CA1999

申请日：1999-09-16

Applicant: KANEKA CORP

Inventor： UEDA YASUYOSHI ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE

IPC: C07B63/00 ,  C07C101/00

公开(公告)号：NO20015042L

公开(公告)日：2001-12-14

申请号：NO20015042

申请日：2001-10-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  G01N

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

公开(公告)号：NO20015042A

公开(公告)日：2001-12-14

申请号：NO20015042

申请日：2001-10-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  G01N

CPC classification number: C07D203/08 ,  C07B2200/07 ,  C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/30 ,  C07C303/36 ,  C07D203/20 ,  C07D203/24 ,  C07C311/19 ,  C07C229/26

公开(公告)号：AU3232701A

公开(公告)日：2001-08-27

申请号：AU3232701

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07C227/04 ,  C07B53/00

Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.