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公开(公告)号：GB2363026B
公开(公告)日：2003-03-19
申请号：GB0108719
申请日：2001-04-06
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HOFFMANN JUERGEN , GUGEL HILMAR , BEWERSDORF JOERG
Abstract: The present invention concerns a double confocal scanning microscope ( 1 ) having an illuminating beam path ( 2 ) of at least one light source ( 3 ), and a detected beam path ( 4 ) of at least one detector ( 5 ), and in order to achieve almost the theoretically possible resolution capability, in particular in the context of multi-color fluorescence applications, is characterized in that the optical properties in particular of the components ( 6, 10, 13, 14 ) arranged in the beam path are coordinated with one another in such a way that the accumulated aberrations, with respect to the optical axis ( 33 ) and/or at least one surface ( 18, 19, 20 ) in the specimen region, are at least of the order of magnitude of the theoretically achievable resolution capability.
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公开(公告)号：GB2369193B
公开(公告)日：2002-11-06
申请号：GB0114026
申请日：2001-06-08
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HAY WILLIAM C , HOFFMANN JUERGEN
Abstract: An optical arrangement, in particular a laser scanning microscope, having a light source, in particular a laser light source, and an interruption device (1) for a light beam (2) of the light source, is configured, in the interest of reliable operation, in such a way that means (3) for monitoring the functioning of the interruption device (1) are associated with the interruption device (1). The invention additionally concerns a shutter (5) for a light beam (2) of a light source, in particular a laser light source, which, again in the interest of reliable operation of an optical arrangement, is characterized by at least two movable components (6, 7) which are configured and arranged such that the mechanical momentum generated by a moving component (6) or by several moving components is compensated for by the motion of the other component (7) or components.
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公开(公告)号：DE10120425A1
公开(公告)日：2002-10-31
申请号：DE10120425
申请日：2001-04-26
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HOFFMANN JUERGEN
Abstract: An illuminating light (15) lights up a specimen (27) and multiples for first and second wavelengths. A detector (65,77,79) detects detection light (29) emitted from the specimen. A scan microscope (1) has a source of light (3) that emits illuminating light (15) to light up the specimen that has two optical blending lines and can be excited with light of first and second wavelengths. A lens (25) focuses the illuminating light on a sectional area of the specimen. An Independent claim is also included for a scan microscope with a source of light for illuminating a specimen excited optically with light of first and second wavelengths and with two optical blending lines.
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公开(公告)号：GB2361324B
公开(公告)日：2002-09-04
申请号：GB0106626
申请日：2001-03-16
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HOFFMANN JUERGEN , STORZ RAFAEL , ULRICH HEINRICH , BEWERSDORF JOERG , BIRK HOLGER
Abstract: The present invention concerns an apparatus for combining light from at least two laser light sources, preferably in the context of confocal scanning microscopy, and in order to make laser light sources of low output power usable as light sources, in particular for confocal scanning microscopy, is characterized in that the light from the laser light sources has at least approximately the same wavelength; and that at least one beam combining unit that combines the light beams in at least largely lossless fashion is provided.
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公开(公告)号：GB2369193A
公开(公告)日：2002-05-22
申请号：GB0114026
申请日：2001-06-08
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HAY WILLIAM C , HOFFMANN JUERGEN
Abstract: An optical arrangement, in particular a laser scanning microscope, having a light source, in particular a laser light source, and an interruption device (1) for a light beam (2) of the light source, is configured, in the interest of reliable operation, in such a way that means (3) for monitoring the functioning of the interruption device (1) are associated with the interruption device (1). The invention additionally concerns a shutter (5) for a light beam (2) of a light source, in particular a laser light source, which, again in the interest of reliable operation of an optical arrangement, is characterized by at least two movable components (6, 7) which are configured and arranged such that the mechanical momentum generated by a moving component (6) or by several moving components is compensated for by the motion of the other component (7) or components.
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Patent Agency Ranking
公开(公告)号：DE10046199A1
公开(公告)日：2002-03-28
申请号：DE10046199
申请日：2000-09-19
Applicant: LEICA MICROSYSTEMS
Inventor： KNEBEL WERNER , HOFFMANN JUERGEN
Abstract: Method has the following steps: selection (30) of a section of the signature to examine, scanning (32) of the selected area using a light beam in a number of planes, blocking off (34) of light not originating from the focussed region, planar detection (36) of light from the focal region and production (38) of a 3-D depiction of the focal region using the detected data. The invention also relates to a device for use with the above method having a light source, shutters, microscope optics, beam deflector and multi-band detection optics.
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公开(公告)号：DE10042840A1
公开(公告)日：2002-03-14
申请号：DE10042840
申请日：2000-08-30
Applicant: LEICA MICROSYSTEMS
Inventor： KNEBEL WERNER , HOFFMANN JUERGEN
Abstract: The present invention relates to a device and to a method for the excitation of fluorescent markers in multiphoton scanning microscopy, having at least one illumination beam path, a light source that produces the illumination light and at least one detection beam path for a detector, the objects to be studied being labelled with fluorescent markers. So as to avoid making it necessary to increase the illumination power of the light source in order to achieve an increase in the fluorescence photon yield, the device according to the invention and the method according to the invention are characterized in that at least one means that influences the spectral distribution/composition of the illumination light is provided for variably influencing the illumination light that excites the fluorescent markers, in particular during the illumination process.
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公开(公告)号：GB2363026A
公开(公告)日：2001-12-05
申请号：GB0108719
申请日：2001-04-06
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HOFFMANN JUERGEN , GUGEL HILMAR , BEWERSDORF JOERG
Abstract: A double confocal scanning microscope (1) has an illuminating beam path (2) associated with a light source (3) and a detected beam path (4) associated with a detector (5). In order to achieve a resolution capability approaching that theoretically possible, in particular in the context of multi-color fluorescence applications, the optical properties of components (6, 10, 13, 14) arranged in the beam path are co-ordinated with one another in such a way that the accumulated aberrations, with respect to the optical axis (33) and/or at least one surface (18, 19, 20) in a specimen support region, are at least of the order of magnitude of the theoretically achievable resolution capability.
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公开(公告)号：DE10018256A1
公开(公告)日：2001-10-25
申请号：DE10018256
申请日：2000-04-13
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , BEWERSDORF JOERG , GUGEL HILMAR , HOFFMANN JUERGEN
Abstract: The present invention concerns a double confocal scanning microscope ( 1 ) having an illuminating beam path ( 2 ) of at least one light source ( 3 ), and a detected beam path ( 4 ) of at least one detector ( 5 ), and in order to achieve almost the theoretically possible resolution capability, in particular in the context of multi-color fluorescence applications, is characterized in that the optical properties in particular of the components ( 6, 10, 13, 14 ) arranged in the beam path are coordinated with one another in such a way that the accumulated aberrations, with respect to the optical axis ( 33 ) and/or at least one surface ( 18, 19, 20 ) in the specimen region, are at least of the order of magnitude of the theoretically achievable resolution capability.
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公开(公告)号：DE102004011770B4
公开(公告)日：2005-12-15
申请号：DE102004011770
申请日：2004-03-09
Applicant: LEICA MICROSYSTEMS
Inventor： MOELLMANN KYRA , HOFFMANN JUERGEN
Abstract: Scanning microscope comprises a beam deflection device (1) that deflects a first illuminating light beam (5) to scan a sample (13), and a second beam deflection device (33) that deflects a second illuminating light beam (37). The first and the second beam deflection device deflect the second illuminating light beam. - An INDEPENDENT CLAIM is also included for a module comprising a second beam deflection device for coupling to a scanning microscope with a first beam deflection device. Preferred Features: The first and the second beam deflection devices are synchronized with each other.
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