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公开(公告)号：NZ624460A
公开(公告)日：2015-12-24
申请号：NZ62446010
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： KRUEGER BRIAN R , ROEPER STEFANIE , ZLOKARNIK GREGOR , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , YAP DAHRIKA MILFRED LAO , LOOKER ADAM R , GROOTENHUIS PETER D J , DEMATTEI JOHN , RYAN MICHAEL P , BOTFIELD MARTYN C , VAN GOOR FREDRICK F
IPC: C07C201/08 , C07B63/04 , C07C205/43 , C07C209/36 , C07C211/45
Abstract: The disclosure provides a process for the preparation of a compound of Formula 8; comprising nitrating a compound of Formula 7; The compound of Formula 5 may further be prepared by reduction of 8. where R2 and R4 are each tert-butyl, and PG is a protecting group such as propoxy formyl, methanesulfonyl, 4-nitrobenzoyl, ethoxy formyl, butoxy formyl, t-butoxy formyl, i-propoxy formyl or methoxy formyl.
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52.发明专利
公开(公告)号：PT2408750E
公开(公告)日：2015-10-15
申请号：PT10710749
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER D J , DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GOOR FREDERICK F VAN , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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公开(公告)号：HK1201827A1
公开(公告)日：2015-09-11
申请号：HK15102284
申请日：2015-03-06
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：ZA201100226B
公开(公告)日：2012-06-27
申请号：ZA201100226
申请日：2011-01-07
Applicant: VERTEX PHARMA
Inventor： NUGENT WILLIAM A , LOOKER ADAM R , FORSLUND RAYMOND E , MARTINOT THEODORE A , HARRISON CRISTIAN L , IBRAHIM SHEREE
IPC: C07D20060101
Abstract: The invention provides beta-sulfonamide alpha-keto esters and amides in which the alpha-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
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Patent Agency Ranking55.发明专利
公开(公告)号：MX2011009867A
公开(公告)日：2012-01-12
申请号：MX2011009867
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： TRUDEAU MARTIN , BOTFIELD MARTYN C , GROOTENHUIS PETER D J , DEMATTEI JOHN , ZLOKARNIK GREGOR , LOOKER ADAM R , ROEPER STEFANIE , NEUBERT-LANGILLE BOBBIANNA , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GOOR FREDERICK F VAN
IPC: C07D215/233
Abstract: La invención proporciona un proceso para la preparación de un compuesto de la Fórmula I (ver fórmula (1), que comprende acoplar un ácido carboxílico de la Fórmula 2 (ver fórmula (2)); con una anilina de la Fórmula 3 (ver fórmula (3)); en presencia de un agente de acoplamiento.
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公开(公告)号：AU2010213629A2
公开(公告)日：2011-09-22
申请号：AU2010213629
申请日：2010-02-12
Applicant: VERTEX PHARMA
Inventor： STEFANIE ROEPER , LOOKER ADAM R , MARTINOT THEODORE A , BOBBIANNA NEUBERT-LANGILLE , RYAN MICHAEL P , SNOONIAN JOHN R
IPC: C07D213/80 , A61K31/4418 , A61P29/00 , A61P37/06 , C07D213/803
Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
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公开(公告)号：AU2010213629A1
公开(公告)日：2011-09-01
申请号：AU2010213629
申请日：2010-02-12
Applicant: VERTEX PHARMA
Inventor： STEFANIE ROEPER , LOOKER ADAM R , MARTINOT THEODORE A , BOBBIANNA NEUBERT-LANGILLE , RYAN MICHAEL P , SNOONIAN JOHN R
IPC: C07D213/80 , A61K31/4418 , A61P29/00 , A61P37/06 , C07D213/803
Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
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公开(公告)号：CA2729823A1
公开(公告)日：2010-01-07
申请号：CA2729823
申请日：2009-07-02
Applicant: VERTEX PHARMA
Inventor： NUGENT WILLIAM A , LOOKER ADAM R , FORSLUND RAYMOND E , MARTINOT THEODORE A , HARRISON CRISTIAN L , IBRAHIM SHEREE
IPC: C07D339/06
Abstract: The invention provides ß-sulfonamide a-keto esters and amides in which the a-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
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公开(公告)号：AU2009266318A1
公开(公告)日：2010-01-07
申请号：AU2009266318
申请日：2009-07-02
Applicant: VERTEX PHARMA
Inventor： FORSLUND RAYMOND E , MARTINOT THEODORE A , NUGENT WILLIAM A , IBRAHIM SHEREE , HARRISON CRISTIAN L , LOOKER ADAM R
IPC: C07D339/06
Abstract: The invention provides beta-sulfonamide alpha-keto esters and amides in which the alpha-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
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