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    THROMBOSIS RISK TEST
    52.
    发明公开
    THROMBOSIS RISK TEST 无效
    测试血栓形成的危险

    公开(公告)号：EP0830608A1

    公开(公告)日：1998-03-25

    申请号：EP96919107.0

    申请日：1996-06-06

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： CAMPBELL, Paula, A. ,  PREDA, Luigi

    IPC: G01N33 ,  C12Q1

    CPC classification number: G01N33/86 ,  G01N2333/4626 ,  G01N2333/745 ,  G01N2333/96461 ,  G01N2333/96463 ,  G01N2405/04

    Abstract: The present invention provides a method for determining thrombotic risk in an individual. The method involves determining the activity of Protein C and Protein S in the plasma of the individual thought to be at thrombotic risk by adding to a plasma sample obtained from the individual: (i) a first reagent in an amount sufficient to induce or activate coagulation in the plasma, (ii) a second reagent which activates endogenous protein C in the plasma, and (iii) a third reagent comprising calcium salts, phospholipids or tissue thromboplastin, or a combination thereof. To a second plasma sample from the same subject is added a reagent which induces or activates coagulation, and a buffer or other material which does not activate protein C, and a third reagent as described above. The time, rate or both, necessary for the conversion of endogenous fibrinogen to fibrin in both the first and second samples is measured. The same steps are performed on normal control plasma, and the difference or ratio in the times, rates, or both, obtained above are determined. The difference or ratio is indicative of the thrombotic risk in the subject. A kit adapted to carry out the method also is the subject of the present invention. The methods and kits of the invention in other embodiments may comprise a first reagent comprising a synthetic substrate, a second reagent which in the first sample from the subject activates protein C, and in the second sample, a second reagent which does not activate protein C. In these embodiments, the rates of hydrolysis of the synthetic substrates are measured and compared.

    Fluid circulating and intercepting devices
    54.
    发明公开
    Fluid circulating and intercepting devices 失效
    Vorrichtung zumÖffnenund Unterbrechen des Durchflusses。

    公开(公告)号：EP0562694A1

    公开(公告)日：1993-09-29

    申请号：EP93200854.3

    申请日：1993-03-24

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Calzi, Claudio ,  Bonfiglio, Paolo ,  Frackleton, John James

    IPC: F16K11/02

    CPC classification number: F16K7/17

    Abstract: A fluid circulating and intercepting device (10) comprises a first (12) and a second block (11) facing each other with the interposition of an impermeable elastic and flexible diaphragm (13). The first block (12) is provided with at least one concavity (16) with its mouth close to the diaphragm (13) and into which opens out in a substantially axial direction a control fluid feed duct (17). The second block (11) is provided with ducts (14, 15) for circulation of the intercepted fluid which open out on the face in contact with the diaphragm (13), in correspondence with the concavity (16) in the first block (12).

    Abstract translation: 流体循环和拦截装置（10）包括彼此面对的第一（12）和第二块（11），其中插入不渗透的弹性和柔性隔膜（13）。 第一块（12）设置有至少一个凹口（16），其口靠近隔膜（13），并且在基本上轴向方向上开放控制流体供给管道（17）。 第二块（11）设有管道（14,15），用于与在第一块（12）中的凹部（16）相对应地在与隔膜（13）接触的面上开放的被截流的流体循环 ）。

    Stable aqueous NADH reagent and kit
    55.
    发明公开
    Stable aqueous NADH reagent and kit 失效
    StabilewässrigeNADH-Reagenz und Testsatz。

    公开(公告)号：EP0463755A1

    公开(公告)日：1992-01-02

    申请号：EP91305127.2

    申请日：1991-06-06

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： San George, Richard C. ,  Adiletto, Carol A.

    IPC: C12Q1/00 ,  C12Q1/32 ,  C12Q1/52

    CPC classification number: C12Q1/32 ,  C12Q1/008 ,  C12Q1/52 ,  Y10S435/81 ,  Y10S435/975 ,  Y10T436/107497

    Abstract: An aqueous coenzyme reagent composition contains NADH, a carbonate/bicarbonate buffer (with a pH of about 9.5 - 11) and water. Both NADH and the buffer are at low concentrations, e.g., about 2 - 5 mM for NADH and about 2 - 15 mM for carbonate/bicarbonate. When this coenzyme reagent is mixed with an enzyme reagent, the mixture achieves a neutral pH. The combination of high pH, low NADH concentration and low buffer concentration permit the aqueous reagent to be stored for extended periods at low temperatures without NADH degrading to form impurities which interfere with or inhibit enzyme activity, such as the activity of lactate dehydrogenase or malate dehydrogenase in an assay for ALT or AST.

    Abstract translation: 含水辅酶试剂组合物含有NADH，碳酸盐/碳酸氢盐缓冲液（pH约9.5-11）和水。 NADH和缓冲液均为低浓度，例如对于NADH为约2-5mM，对于碳酸盐/碳酸氢盐为约2-15mM。 当该辅酶试剂与酶试剂混合时，混合物达到中性pH。 高pH值，低NADH浓度和低缓冲浓度的组合允许水性试剂在低温下长时间储存​​，而不会使NADH降解以形成干扰或抑制酶活性的杂质，例如乳酸脱氢酶或苹果酸脱氢酶的活性 在ALT或AST的检测中。

    Measurement of calcium ions
    58.
    发明公开
    Measurement of calcium ions 失效
    钙离子的测量

    公开(公告)号：EP0304151A3

    公开(公告)日：1990-09-12

    申请号：EP88306087.3

    申请日：1988-07-04

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Musacchio, John ,  Premoli, Pietro ,  Manzoni, Angelo ,  Bergkuist, Carolyn

    IPC: G01N33/84

    CPC classification number: G01N33/84

    Abstract: A method for determining the concentrations of total calcium and at least one monovalent ion in a sample includes the steps of mixing the sample with a diluent that has a pH within the range pH 6.5 to 7.0 and includes 2-amino-2-hydroxymethyl-1,3 propanediol phosphate and is free of the monovalent ion. An aliquot of the diluted sample is concurrently contacted with a calcium-specific ion selective electrode and an ion selective electrode specifically responsive to the monovalent ion, the response of the calcium-specific ion selective electrode is measured as an indication of the concentration of total calcium in the sample, and the response of the monovalent ion specific ion selective electrode is measured as an indication of the concentration of the monovalent ion in the sample.

    Fluid handling
    59.
    发明公开
    Fluid handling 失效
    流体处理

    公开(公告)号：EP0299661A3

    公开(公告)日：1990-08-29

    申请号：EP88306089.9

    申请日：1988-07-04

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Geiselman, Theodore S. ,  Rasmussen, James

    IPC: G01N35/08

    CPC classification number: G01N35/085

    Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.

    Liquid handling
    60.
    发明公开
    Liquid handling 失效
    液体处理

    公开(公告)号：EP0299659A3

    公开(公告)日：1990-08-22

    申请号：EP88306086.5

    申请日：1988-07-04

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Geiselman, Theodore S.

    IPC: G01N35/08 ,  G01N35/06 ,  G01N1/00

    CPC classification number: G01N35/085 ,  G01N35/10 ,  G01N2035/00326

    Abstract: An analysis system includes analysis station structure, sample station structure spaced from the analysis station structure along a straight line path, support shaft structure disposed along an axis parallel to the straight line path, and a transport carriage with probe structure mounted on the carriage. The transport carriage is mounted on the support shaft structure for movement along that shaft and is keyed thereto for pivoting movement in response to rotation of the shaft. A first drive includes a drive motor and cable structure coupled between the carriage and the drive motor for moving the transport carriage along the shaft to selectively position the probe structure at the sample and analysis stations, and a second drive rotates the shaft for inserting the probe into and withdrawing the probe from chamber structure at the sample and analysis stations. Metering means coupled to the probe flows liquid into and discharges liquid from the probe.

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