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    주름개선용 화장료 조성물
    61.
    发明授权
    주름개선용 화장료 조성물 有权
    用于改善皮肤皱纹活性的化妆品组合物

    公开(公告)号：KR101472119B1

    公开(公告)日：2014-12-26

    申请号：KR1020120131029

    申请日：2012-11-19

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 김영옥 ,  이상원

    IPC: A61K8/97 ,  A61Q19/08 ,  A61Q19/00

    Abstract: 본발명은피부주름개선화장료조성물에관한것으로, 더욱상세하게는천연생약재추출물을함유하는것을특징으로하는화장료조성물이다. 또한본 발명은생약재추출물을화장료에함유시킴으로서콜라겐합성을촉진하여피부주름을완화시킬수 있고하고, 피부를견고하며탄력있게유지해주는효과가있다.

    비만 및 지질관련 대사성 질환의 예방 및 치료용 조성물 및 그 제조방법
    65.
    发明公开
    비만 및 지질관련 대사성 질환의 예방 및 치료용 조성물 및 그 제조방법 有权
    用于预防和治疗包含金松提取物的肥胖和脂质代谢的组合物

    公开(公告)号：KR1020140065661A

    公开(公告)日：2014-05-30

    申请号：KR1020120131218

    申请日：2012-11-19

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 김영옥 ,  이상원 ,  김승유 ,  신유수

    IPC: A61K36/258 ,  A61K36/28 ,  A61K36/752 ,  A61P3/04

    Abstract: The present invention relates to a composition for preventing and treating obesity and lipid-related metabolic diseases and a method for manufacturing the same. The composition of the present invention comprising powdered herbal components can suppress differentiation of adipocytes and generation of triglycerides, has excellent functionality, and has an effect of inhibiting obesity such as weight loss and blood lipid level reduction in obesity-induced animals by inhibiting differentiation of adipocytes, thereby being greatly helpful for preventing and treating obesity and lipid-related metabolic diseases.

    Abstract translation: 本发明涉及用于预防和治疗肥胖症和与脂质有关的代谢疾病的组合物及其制造方法。 包含粉末草药成分的本发明的组合物可以抑制脂肪细胞的分化和甘油三酯的产生，具有优异的功能性，并且具有通过抑制脂肪细胞分化来抑制肥胖诱导的动物的肥胖，例如体重减轻和血脂水平降低的作用 从而对预防和治疗肥胖症和脂质代谢疾病有很大的帮助。

    지치 뿌리의 천연 색소를 함유하는 골관절염 예방 및 치료용 조성물 및 이의 제조 방법
    67.
    发明公开
    지치 뿌리의 천연 색소를 함유하는 골관절염 예방 및 치료용 조성물 및 이의 제조 방법 有权
    用于预防或治疗包括LITHOSPERMI RADIX的天然色素的OSTEOARTHRITIS的组合物及其制备方法

    公开(公告)号：KR1020130084372A

    公开(公告)日：2013-07-25

    申请号：KR1020120005085

    申请日：2012-01-17

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 김금숙 ,  박춘근 ,  이승은 ,  노형준 ,  김영옥 ,  김승유 ,  김형돈 ,  홍윤표

    IPC: A61K36/30 ,  A61P19/02 ,  A61P19/00

    Abstract: PURPOSE: A composition containing a Lithospermum erythrorhizon Sieb. et Zucc. root extract is provided to significantly treat osteoarthritis and to be used as an agent for preventing and treating osteoarthritis or as a health food for treating osteoarthritis. CONSTITUTION: A therapeutic agent for treating osteoarthritis contains effective amount of natural pigments of Lithospermum erythrorhizon Sieb. et Zucc. roots. The natural pigment is a shikonin derivative, acetyl shikonin. An agent for preventing osteoarthritis contains effective amount of the natural pigments. A method for preparing a Lithospermum erythrorhizon Sieb. et Zucc. root extract for preventing and treating osteoarthritis comprises the steps of extracting Lithospermum erythrorhizon Sieb. et Zucc. roots with a non-polar solvent and obtaining the natural pigments. A method for preparing a Lithospermum erythrorhizon Sieb. et Zucc. root extract for preventing and treating osteoarthritis comprises the step of extracting the natural pigments by supercritical extraction. [Reference numerals] (G2) MIA + green-shelled mussel oil extract 150mg/kg; (G3) MIA + supercritical extract of Lithospermum erythrorhizon Sieb. et Zucc. 200mg/kg; (G4) MIA + acetylshikonin of Lithospermum erythrorhizon Sieb. et Zucc. 5mg/kg

    Abstract translation: 目的：一种含有紫草紫草素的组合物。 等Zucc。 提供根提取物以显着治疗骨关节炎并且用作预防和治疗骨关节炎的药剂或用作治疗骨关节炎的保健食品。 构成：用于治疗骨关节炎的治疗剂含有有效量的紫苏紫苏的天然色素。 等Zucc。 根。 天然色素是紫草素衍生物，乙酰紫草素。 用于预防骨关节炎的药物含有有效量的天然色素。 一种制备紫苏红赤霉素的方法。 等Zucc。 用于预防和治疗骨关节炎的根提取物包括提取紫苏红赤霉素Sieb的步骤。 等Zucc。 根用非极性溶剂并获得天然颜料。 一种制备紫苏红赤霉素的方法。 等Zucc。 用于预防和治疗骨关节炎的根提取物包括通过超临界萃取提取天然色素的步骤。 [参考数字]（G2）MIA +绿壳贻贝油提取物150mg / kg; （G3）MIA +超临界提取物。 等Zucc。 200mg / kg的; （G4）MIA +紫草素的紫草素。 等Zucc。 为5mg / kg

    폴딩되는 큰 활성 단백질의 수용성 발현
    69.
    发明授权
    폴딩되는 큰 활성 단백질의 수용성 발현 有权
    大体积折叠的活性蛋白的可溶性表达

    公开(公告)号：KR101184011B1

    公开(公告)日：2012-09-27

    申请号：KR1020100043855

    申请日：2010-05-11

    Applicant: 대한민국(관리부서:국립수산과학원)

    Inventor： 이상준 ,  김영옥 ,  남보혜 ,  공희정 ,  김경길

    IPC: C12N15/63 ,  C12N15/11

    CPC classification number: C12N15/625 ,  C07K2319/02 ,  C07K2319/50 ,  C12N15/70 ,  C12P21/06

    Abstract: The present invention relates to expression vectors and methods for enhancing soluble expression and secretion of a heterologous protein, particularly a bulky folded active heterologous protein which has one or more transmembrane-like domains or intramolecular disulfide bonds by linking a leader peptide with acidic or basic pI and high hydrophilicity thereto; by substituting one or more amino acids within N-terminal of the heterologous protein with ones having acidic or neutral pI and high hydrophilicity; or reducing elevating GRNA value of a polynucleotide encoding the leader peptide having basic pI value and high hydrophilicity. The expression vector and the method may be used to produce of heterologous protein and to transduce of therapeutic proteins in a patient by preventing formation of insoluble inclusion body and by enhancing secretional efficiency of the heterologous protein into the periplasm or outside cell.

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