公开(公告)号：CA2765093A1

公开(公告)日：2004-05-27

申请号：CA2765093

申请日：2003-11-05

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  SHARMA PADAM N ,  BENNANI YOUSSEF L ,  CURTIS MICHAEL P

IPC: C07D401/00 ,  A61K31/40 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/465 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61P3/00 ,  A61P25/00 ,  C07C255/58 ,  C07D207/04 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/092 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

Abstract: Compounds of forumla (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositins, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：ES2196331T3

公开(公告)日：2003-12-16

申请号：ES97922483

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  CURTY CYNTHIA BRUNELL ,  FAGHIH RAMIN ,  NELLANS HUGH NERBY ,  PETERSEN ALBERT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：DK1021456T3

公开(公告)日：2003-08-18

申请号：DK97922483

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  CURTY CYNTHIA BRUNELL ,  FAGHIH RAMIN ,  NELLANS HUGH NERBY ,  PETERSEN ALBERT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：PE20020928A1

公开(公告)日：2002-10-26

申请号：PE2002000203

申请日：2002-03-15

Applicant: ABBOTT LAB

Inventor： BENMANI YOUSSEF L ,  BLACK LAWRENCE A ,  GFESSER GREGORY A ,  FAGHIH RAMIN ,  COWART MARION D

IPC: A61K31/343 ,  A61K31/4427 ,  A61P9/00 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D405/04 ,  C07D405/06 ,  C07D407/04 ,  C07D409/04 ,  C07D417/04 ,  A61P11/0

Abstract: SE REFIERE A COMPUESTOS BENZOFURANOS DE FORMULA I DONDE A ES CARBONILO, ENLACE; D ES O, S; L ES ALQUILENO, FLUOROALQUILENO, HIDROXIALQUILENO; P Y Q FORMAN JUNTOS UN ENLACE, H; R1 Y R2 SON H, ALQUILO, ARILO, ARILALQUILO, CICLOALQUILO, ENTRE OTROS; R3 ES H, ALCOXI, ALCOXICARBONILO, ALQUILO, ENTRE OTROS, NRARB; R4, R5, R6, R7 SON H, ALCOXI, ALCOXICARBONILO, ALQUILO, ALQUILCARBONILO, ENTRE OTROS; L2 ES ALQUILENO, ALQUENILENO, O, S, SO, SO2, ENTRE OTROS; L3 ES ENLACE, ALQUENILENO, O, S, CO, NOR21, NRA; R20 ES ARILO, HETEROCICLO, CICLOALQUILO; R21 Y R22 SON H, ALQUILO; RA Y RB SON H, ALQUILO, ALQUILCARBONILO, FORMILO; AL MENOS UNO DE R4-R7 ES ARILO, HETEROCICLO, CICLOALQUILO, L2R20, R20L3R22. SON COMPUESTOS PREFERIDOS (4-FLUOROFENILO)(2-{2-[(2R)-2-METIL-1-PIRROLIDINIL]ETIL}-1-BENZOFURAN-5-IL)METANONA; 4-(2-{2-[(2R)-2-METIL-1-PIRROLIDINIL]ETIL}-1-BENZOFURAN-4-IL)BENZONITRILO; 4-(2-{2-[(2R)-2-METILPIRROLIDINIL]ETIL}-2,3DIHIDRO-1-BENZOFURAN-5-IL)BENZONITRILO; ENTRE OTROS. LOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE HISTAMINA-3 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE NARCOLEPSIA, OBESIDAD, DEFICIENCIA COGNITIVA LEVE, DEFICIT DE LA MEMORIA, ASMA

公开(公告)号：PE09282002A1

公开(公告)日：2002-10-26

申请号：PE0002032002

申请日：2002-03-15

Applicant: ABBOTT LAB

Inventor： BENMANI YOUSSEF L ,  BLACK LAWRENCE A ,  GFESSER GREGORY A ,  FAGHIH RAMIN ,  COWART MARION D

IPC: A61K31/343 ,  A61K31/4427 ,  A61P9/00 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D405/04 ,  C07D405/06 ,  C07D407/04 ,  C07D409/04 ,  C07D417/04 ,  A61P11/0

Abstract: SE REFIERE A COMPUESTOS BENZOFURANOS DE FORMULA I DONDE A ES CARBONILO, ENLACE; D ES O, S; L ES ALQUILENO, FLUOROALQUILENO, HIDROXIALQUILENO; P Y Q FORMAN JUNTOS UN ENLACE, H; R1 Y R2 SON H, ALQUILO, ARILO, ARILALQUILO, CICLOALQUILO, ENTRE OTROS; R3 ES H, ALCOXI, ALCOXICARBONILO, ALQUILO, ENTRE OTROS, NRARB; R4, R5, R6, R7 SON H, ALCOXI, ALCOXICARBONILO, ALQUILO, ALQUILCARBONILO, ENTRE OTROS; L2 ES ALQUILENO, ALQUENILENO, O, S, SO, SO2, ENTRE OTROS; L3 ES ENLACE, ALQUENILENO, O, S, CO, NOR21, NRA; R20 ES ARILO, HETEROCICLO, CICLOALQUILO; R21 Y R22 SON H, ALQUILO; RA Y RB SON H, ALQUILO, ALQUILCARBONILO, FORMILO; AL MENOS UNO DE R4-R7 ES ARILO, HETEROCICLO, CICLOALQUILO, L2R20, R20L3R22. SON COMPUESTOS PREFERIDOS (4-FLUOROFENILO)(2-{2-[(2R)-2-METIL-1-PIRROLIDINIL]ETIL}-1-BENZOFURAN-5-IL)METANONA; 4-(2-{2-[(2R)-2-METIL-1-PIRROLIDINIL]ETIL}-1-BENZOFURAN-4-IL)BENZONITRILO; 4-(2-{2-[(2R)-2-METILPIRROLIDINIL]ETIL}-2,3DIHIDRO-1-BENZOFURAN-5-IL)BENZONITRILO; ENTRE OTROS. LOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE HISTAMINA-3 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE NARCOLEPSIA, OBESIDAD, DEFICIENCIA COGNITIVA LEVE, DEFICIT DE LA MEMORIA, ASMA

公开(公告)号：CA2440238A1

公开(公告)日：2002-09-26

申请号：CA2440238

申请日：2002-03-11

Applicant: ABBOTT LAB

Inventor： BLACK LAWRENCE A ,  BENNANI YOUSSEF L ,  GFESSER GREGORY A ,  COWART MARLON D ,  FAGHIH RAMIN

IPC: A61K31/343 ,  A61K31/4025 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/55 ,  A61P1/00 ,  A61P1/08 ,  A61P3/04 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P11/02 ,  A61P11/06 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D307/79 ,  C07D307/81 ,  C07D311/18 ,  C07D333/54 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D491/10 ,  C07D521/00 ,  A61K31/4427

Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, ester, amid e, or prodrug thereof, which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.

公开(公告)号：HK1010054A1

公开(公告)日：1999-06-11

申请号：HK98110890

申请日：1998-09-23

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08 ,  C07H ,  A61K

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：DK0623021T3

公开(公告)日：1999-02-08

申请号：DK93904533

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：CA2257361A1

公开(公告)日：1997-12-24

申请号：CA2257361

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： NELLANS HUGH NERBY ,  FAGHIH RAMIN ,  PETERSEN ALBERT CHRISTIAN ,  LARTEY PAUL A ,  CURTY CYNTHIA BURNELL

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having formula (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：AU656462B2

公开(公告)日：1995-02-02

申请号：AU3586193

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08 ,  A61K31/71

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.