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    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF
    62.
    发明专利
    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF 未知

    公开(公告)号：ZA201400560B

    公开(公告)日：2020-05-27

    申请号：ZA201400560

    申请日：2014-01-23

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  SUPER MICHAEL ,  CWAY JEFFREY CHARLES ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  BERTHET JULIA B ,  SUPER DINAH R ,  ROTTMAN MARTIN M

    Abstract: Described herein are unlabeled engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

    Electrically conductive antifouling coating composition
    63.
    发明专利
    Electrically conductive antifouling coating composition 未知

    公开(公告)号：AU2018307822A1

    公开(公告)日：2020-02-06

    申请号：AU2018307822

    申请日：2018-07-27

    Applicant: HARVARD COLLEGE

    Inventor： HENRY OLIVIER YVES FREDERIC ,  INGBER DONALD E ,  SABATE DEL RIO JONATHAN ,  JOLLY PAWAN

    IPC: C09D5/24 ,  C08K3/20

    Abstract: Carbon nanotubes or graphene combined with proteinaceous material forming compositions that can be coated on surfaces are described. For example, the described compositions can be used as a coating on an electrode. The coatings can be functionalized with capture agents, targeting specific analytes. In addition to being conductive, the coatings prevent fouling and passivation of the electrodes by non-specific binding. This allows the coated electrodes to be used in complex matrices such as can be found in biological fluids and tissues. The coated electrodes can be regenerated and reused repeatedly.

    CELL CULTURE SYSTEM
    64.
    发明专利
    CELL CULTURE SYSTEM 未知

    公开(公告)号：AU2019202169B2

    公开(公告)日：2020-01-23

    申请号：AU2019202169

    申请日：2019-03-28

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  KIM HYUN JUNG

    IPC: C12M3/02 ,  C12N1/14 ,  C12N1/20 ,  C12N5/071

    Abstract: Abstract The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora. - 61- WO 2012/118799 PCT/US2012/026934 - -% 0 -- - 2 'CYD C3 (nuzjIEL; - C= SUSIUTSET(UE6

    Device for reduced oxygen concentration culture in microfluidic systems
    68.
    发明专利
    Device for reduced oxygen concentration culture in microfluidic systems 未知

    公开(公告)号：AU2016389900A1

    公开(公告)日：2018-06-21

    申请号：AU2016389900

    申请日：2016-11-14

    Applicant: HARVARD COLLEGE

    Inventor： OLIVER JOHN W K ,  NOVAK RICHARD ,  CRONCE MICHAEL J ,  INGBER DONALD E ,  WAY JEFFREY C

    IPC: C12M3/00 ,  C12N1/14 ,  C12N1/20

    Abstract: A low-oxygen system is directed to culturing a diverse microbiome and includes an anaerobic chamber and at least one microfluidic device removably inserted in the anaerobic chamber. The microfluidic device includes a first microchannel in which a first level of oxygen is maintained, and a second microchannel in which a second level of oxygen is maintained, the second level of oxygen having a greater oxygen concentration than the first level of oxygen. The microfluidic device further includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane further having a plurality of pores via which oxygen flows from the second microchannel to the first microchannel to form an oxygen gradient in the first microchannel. The system further includes a culture system provided in the first microchannel and including oxygen-sensitive anaerobic bacteria.

    CELL CULTURE SYSTEM
    70.
    发明专利
    CELL CULTURE SYSTEM 未知

    公开(公告)号：AU2017202616A1

    公开(公告)日：2017-05-11

    申请号：AU2017202616

    申请日：2017-04-20

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  KIM HYUN JUNG

    IPC: C12M3/02 ,  C12N1/14 ,  C12N1/20 ,  C12N5/071

    Abstract: Abstract The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.

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