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    Organomimetic devices and methods of use and manufacturing thereof
    2.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903A1

    公开(公告)日：2019-11-14

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG ,  FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    Organomimetic devices and methods of use and manufacturing thereof
    5.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903B2

    公开(公告)日：2021-10-07

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E ,  HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    REMOVING BUBBLES IN MICROFLUIDIC SYSTEMS
    10.
    发明申请
    REMOVING BUBBLES IN MICROFLUIDIC SYSTEMS 审中-公开
    在微流体系统中去除泡沫

    公开(公告)号：WO2014039514A3

    公开(公告)日：2014-06-19

    申请号：PCT/US2013057992

    申请日：2013-09-04

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  HAMILTON GERALDINE A ,  LEVNER DANIEL ,  HINOJOSA CHRISTOPHER ,  PATTERSON DANIEL

    IPC: C12M1/00 ,  B82Y15/00 ,  C12Q1/70

    CPC classification number: B01L3/502723 ,  B01D17/085 ,  B01D19/0031 ,  B01D63/088 ,  B01D71/36 ,  B01D2325/38 ,  B01L3/502715 ,  B01L2200/0684 ,  B01L2300/06 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  C12M23/16 ,  C12M23/24 ,  C12M23/36

    Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.

    Abstract translation: 微流体系统包括连接到气泡捕获装置的微流体装置，由此流到微流体装置的流体通过气泡捕获装置以在进入微流体装置之前去除气泡。 气泡阱可以包括由疏水性多孔膜隔开的分离室和排气室，并且进入分离室的流体中的气泡在流体保留在分离室中时通过疏水性多孔膜进入排气室。 可以通过将第一主体部分接合到疏水性多孔膜的第一侧并将第二主体部分结合到疏水性多孔膜的第二侧来形成气泡捕获器。 排气室可以连接到细长的排气通道，其限制流体通过疏水多孔膜的蒸发损失。

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