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公开(公告)号：AU2014386207A1
公开(公告)日：2016-07-28
申请号：AU2014386207
申请日：2014-12-19
Applicant: FERNANDEZ-ALCON JOSE , HARVARD COLLEGE , WEN NORMAN , NOVAK RICHARD
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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公开(公告)号：AU2019253903A1
公开(公告)日：2019-11-14
申请号：AU2019253903
申请日：2019-10-25
Applicant: HARVARD COLLEGE
Inventor： HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E
Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232
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公开(公告)号：AU2014386207B2
公开(公告)日：2019-08-22
申请号：AU2014386207
申请日：2014-12-19
Applicant: HARVARD COLLEGE
Inventor： VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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公开(公告)号：AU2019268161B2
公开(公告)日：2021-12-02
申请号：AU2019268161
申请日：2019-11-21
Applicant: HARVARD COLLEGE
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: A method of producing a microfluidic device comprising: a) providing a first body and a second body; b) compression molding a polymer to create a porous membrane; and c) positioning the membrane within the central channel. 242 200 244 207 206 202 209 230 -- ,232
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Patent Agency Ranking
公开(公告)号：AU2019253903B2
公开(公告)日：2021-10-07
申请号：AU2019253903
申请日：2019-10-25
Applicant: HARVARD COLLEGE
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232
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公开(公告)号：AU2019268161A1
公开(公告)日：2019-12-12
申请号：AU2019268161
申请日：2019-11-21
Applicant: HARVARD COLLEGE
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: A method of producing a microfluidic device comprising: a) providing a first body and a second body; b) compression molding a polymer to create a porous membrane; and c) positioning the membrane within the central channel. 242 200 244 207 206 202 209 230 -- ,232
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公开(公告)号：CA2944220A1
公开(公告)日：2015-09-17
申请号：CA2944220
申请日：2014-12-19
Applicant: HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
Inventor： FERNANDEZ-ALCON JOSE , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON GUY II , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG , WEN NORMAN , NOVAK RICHARD
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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公开(公告)号：WO2015138032A3
公开(公告)日：2015-12-03
申请号：PCT/US2014071570
申请日：2014-12-19
Applicant: HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
Abstract translation: 有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。 有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流而将机械力施加到细胞。 有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。 有机模拟装置可以通过单独制造各个组件来制造，例如，作为随后层压在一起的各个层。
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9.发明公开
公开(公告)号：EP3083057A4
公开(公告)日：2017-03-08
申请号：EP14885808
申请日：2014-12-19
Applicant: HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
Inventor： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
Abstract translation: 有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。 有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流动而将机械力施加到细胞。 有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。 有机模拟装置可以通过分别制造单独的部件来制造，例如，可以随后层压在一起的单独的层。
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