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    Organomimetic devices and methods of use and manufacturing thereof
    2.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903B2

    公开(公告)日：2021-10-07

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E ,  HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    Microfluidic device having offset, high-shear seeding channels
    3.
    发明专利
    Microfluidic device having offset, high-shear seeding channels 未知

    公开(公告)号：AU2016249832A1

    公开(公告)日：2017-12-07

    申请号：AU2016249832

    申请日：2016-04-08

    Applicant: HARVARD COLLEGE

    Inventor： DOMANSKY KAREL ,  HINOJOSA CHRISTOPHER DAVID ,  INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON II GUY

    IPC: C12M1/00 ,  B82Y15/00 ,  C12M3/04

    Abstract: A microfluidic device for determining a response of cells comprises a microchannel and a seeding channel. The microchannel is at least partially defined by a porous membrane having cells adhered thereto. The microchannel has a first cross-sectional area. The seeding channel delivers a working fluid to the cells within the microchannel. The seeding channel has a second cross-sectional area that is less than the first cross-sectional area such that a flow of the working fluid produces a substantially higher shear force within the seeding channel to inhibit the attachment of cells within the seeding channel. And when multiple seeding channels are used to deliver fluids to multiple microchannels that define an active cellular layer across the membrane, the seeding channels are spatially offset from each other such that fluid communication between the fluids occurs only at the active region via the membrane, not at the seeding channels.

    DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE
    5.
    发明专利
    DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 未知

    公开(公告)号：CA2831857A1

    公开(公告)日：2012-10-04

    申请号：CA2831857

    申请日：2012-04-02

    Applicant: CHILDRENS MEDICAL CENTER ,  HARVARD COLLEGE

    Inventor： YUNG CHONG WING ,  DOMANSKY KAREL ,  TERRY RICHARD C ,  KALISH DAVID ,  SCHULTE ALEXA ,  KANG JOO HUN ,  INGBER DONALD E ,  SUPER MICHAEL ,  COOPER RYAN M

    IPC: G01N33/569 ,  B81B1/00 ,  G01N35/08 ,  G01N35/10

    Abstract: A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

    Organomimetic devices and methods of use and manufacturing thereof
    6.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903A1

    公开(公告)日：2019-11-14

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG ,  FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    MICROFLUIDIC DEVICE HAVING OFFSET, HIGH-SHEAR SEEDING CHANNELS
    8.
    发明专利
    MICROFLUIDIC DEVICE HAVING OFFSET, HIGH-SHEAR SEEDING CHANNELS 未知

    公开(公告)号：CA2982749C

    公开(公告)日：2021-11-16

    申请号：CA2982749

    申请日：2016-04-08

    Applicant: HARVARD COLLEGE

    Inventor： DOMANSKY KAREL ,  HINOJOSA CHRISTOPHER DAVID ,  INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON GUY

    IPC: C12M1/00 ,  B82Y15/00 ,  C12M3/04

    Abstract: A microfluidic device for determining a response of cells comprises a microchannel and a seeding channel. The microchannel is at least partially defined by a porous membrane having cells adhered thereto. The microchannel has a first cross-sectional area. The seeding channel delivers a working fluid to the cells within the microchannel. The seeding channel has a second cross-sectional area that is less than the first cross-sectional area such that a flow of the working fluid produces a substantially higher shear force within the seeding channel to inhibit the attachment of cells within the seeding channel. And when multiple seeding channels are used to deliver fluids to multiple microchannels that define an active cellular layer across the membrane, the seeding channels are spatially offset from each other such that fluid communication between the fluids occurs only at the active region via the membrane, not at the seeding channels.

    MICROFLUIDIC DEVICE HAVING OFFSET, HIGH-SHEAR SEEDING CHANNELS
    10.
    发明专利
    MICROFLUIDIC DEVICE HAVING OFFSET, HIGH-SHEAR SEEDING CHANNELS 未知

    公开(公告)号：CA2982749A1

    公开(公告)日：2016-10-20

    申请号：CA2982749

    申请日：2016-04-08

    Applicant: HARVARD COLLEGE

    Inventor： DOMANSKY KAREL ,  HINOJOSA CHRISTOPHER DAVID ,  INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON GUY II

    IPC: C12M1/00 ,  B82Y15/00 ,  C12M3/04

    Abstract: A microfluidic device for determining a response of cells comprises a microchannel and a seeding channel. The microchannel is at least partially defined by a porous membrane having cells adhered thereto. The microchannel has a first cross-sectional area. The seeding channel delivers a working fluid to the cells within the microchannel. The seeding channel has a second cross-sectional area that is less than the first cross-sectional area such that a flow of the working fluid produces a substantially higher shear force within the seeding channel to inhibit the attachment of cells within the seeding channel. And when multiple seeding channels are used to deliver fluids to multiple microchannels that define an active cellular layer across the membrane, the seeding channels are spatially offset from each other such that fluid communication between the fluids occurs only at the active region via the membrane, not at the seeding channels.

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