公开(公告)号：HU0004149A2

公开(公告)日：2001-05-28

申请号：HU0004149

申请日：1999-07-19

Applicant: KANEKA CORP

Inventor： FUSE YOSHIHIDE ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  UEDA YASUYOSHI ,  YANAGIDA YOSHIFUMI

IPC: A61P9/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/062

Abstract: A method for crystallizing the maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (Enalapril) from an aqueous liquid with ease in good yield, which comprises mixing an aqueous liquid containing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, maleic acid and a base and having a pH of 4 or more with an acid in an amount of the acid sufficient to convert the base to a neutral salt, to thereby crystallize N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline in the form of a maleic acid salt.

公开(公告)号：CZ20001004A3

公开(公告)日：2000-08-16

申请号：CZ20001004

申请日：1999-07-19

Applicant: KANEKA CORP

Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: A61P9/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/062 ,  C07K1/30 ,  C07B57/00

Abstract: A method for crystallizing the maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (Enalapril) from an aqueous liquid with ease in good yield, which comprises mixing an aqueous liquid containing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, maleic acid and a base and having a pH of 4 or more with an acid in an amount of the acid sufficient to convert the base to a neutral salt, to thereby crystallize N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline in the form of a maleic acid salt.

公开(公告)号：CA2216537A1

公开(公告)日：1997-08-07

申请号：CA2216537

申请日：1997-01-29

Applicant: KANEKA CORP

Inventor： SUGAWA TADASHI ,  KAN KAZUNORI ,  INOUE KENJI ,  MOROSHIMA TADASHI

IPC: C07B41/02 ,  C07B53/00 ,  C07C29/143 ,  C07C213/00 ,  C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C319/20 ,  C07C323/43

Abstract: The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing .alpha. -aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formual (4) to provide the corresponding alcohol compound of the general formula (5). (see fig. I) (see fig. II) (see fig. III)

公开(公告)号：JP2006249097A

公开(公告)日：2006-09-21

申请号：JP2006140337

申请日：2006-05-19

Applicant: Kaneka Corp ,  株式会社カネカ

Inventor： MATSUMOTO SHINGO ,  MATSUO KAZUHIKO ,  SUGAKAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI

IPC: C07C227/34 ,  C07B57/00 ,  C07C229/22 ,  C07C269/08 ,  C07C271/22 ,  C07C303/44 ,  C07C311/19

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a β-amino-α-hydroxy acid derivative by a process regarded to be efficiently and industrially usable.
SOLUTION: The method for producing a β-amino-α-hydroxy acid derivative represented by general formula (2) comprises hydrolyzing an α-amino-α',α'-dihaloketone derivative represented by general formula (1) in the presence of a base and then protecting or non-protecting the amino group.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供通过被认为是有效和工业上可用的方法制备β-氨基-α-羟基酸衍生物的方法。 解决方案：由通式（2）表示的β-氨基-α-羟基酸衍生物的制备方法包括将通式（1）表示的α-氨基-α'，α'-二卤代酮衍生物水解成 碱的存在，然后保护或不保护氨基。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：EP1179530A4

公开(公告)日：2005-07-27

申请号：EP01904517

申请日：2001-02-16

Applicant: KANEKA CORP

Inventor： SUGAWARA MASANOBU ,  FUJII AKIO ,  OKURO KAZUMI ,  SAKA YASUHIRO ,  NAGASHIMA NOBUO ,  INOUE KENJI ,  TAKEDA TOSHIHIRO ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

IPC: C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/26 ,  C07C229/30 ,  C07C303/36 ,  C07C311/19 ,  C07D203/08 ,  C07D203/20 ,  C07D203/24 ,  C07B53/00 ,  C07C227/04

CPC classification number: C07D203/08 ,  C07B2200/07 ,  C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/30 ,  C07C303/36 ,  C07D203/20 ,  C07D203/24 ,  C07C311/19 ,  C07C229/26

Abstract: An optically active amino acid derivative is prepared either by subjecting an optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protected with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3-haloalanine derivative to N-protection to obtain an optically active 3-haloalanine derivative (4) whose amino group is protected with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R?1 and R2¿ are each hydrogen or the like; * represents an asymmetric carbon atom; and P1 is 2- and/ or 4- nitrated benzenesulfonyl.

公开(公告)号：EP0827943A4

公开(公告)日：2000-07-26

申请号：EP97901761

申请日：1997-01-29

Applicant: KANEKA CORP

Inventor： SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI ,  KAN KAZUNORI

IPC: C07B41/02 ,  C07B53/00 ,  C07C29/143 ,  C07C213/00 ,  C07C269/06 ,  C07C271/16 ,  C07C271/22 ,  C07C319/20 ,  C07C323/43 ,  C07C33/22 ,  C07C215/28 ,  C07C271/10

CPC classification number: C07B53/00 ,  C07B41/02 ,  C07C29/143 ,  C07C213/00 ,  C07C269/06 ,  C07C319/20 ,  C07C323/43 ,  C07C271/16 ,  C07C271/22 ,  C07C33/22 ,  C07C33/46

Abstract: The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing alpha -aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formual (4) to provide the corresponding alcohol compound of the general formula (5).

公开(公告)号：EP0930292A4

公开(公告)日：2000-07-12

申请号：EP97935797

申请日：1997-08-18

Applicant: KANEKA CORP

Inventor： MATSUMOTO SHINGO ,  MATSUO KAZUHIKO ,  SUGAWA TADASHI ,  MOROSHIMA TADASHI ,  INOUE KENJI

IPC: C07C227/02 ,  C07C227/42 ,  C07C229/22 ,  C07C229/34 ,  C07C229/36 ,  C07C269/08 ,  C07C271/18 ,  C07C271/22 ,  C07C303/40 ,  C07C303/44 ,  C07C311/19 ,  C07D209/26 ,  C07D209/48

CPC classification number: C07C303/44 ,  C07C227/02 ,  C07C227/42 ,  C07C269/08 ,  C07C271/18 ,  C07C303/40 ,  C07D209/26 ,  Y02P20/55 ,  C07C311/19 ,  C07C229/22 ,  C07C229/34

Abstract: A process for preparing β-amino-α-hydroxy acid derivatives in an efficient and commercially useable manner. The process is characterized by hydrolyzing an α-amino-α',α'-dihaloketone derivative represented by general formula (1) in the presence of a base, optionally followed by the protection of the amino group, to prepare a β-amino-α-hydroxy acid derivative represented by general formula (2).

公开(公告)号：EP2842950A4

公开(公告)日：2015-10-21

申请号：EP13782097

申请日：2013-02-27

Applicant: KANEKA CORP

Inventor： UEKITA KEN ,  MOROSHIMA TADASHI

IPC: C07D303/32 ,  A23L1/30 ,  A61K8/49 ,  A61K31/336 ,  A61P3/04 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D301/32 ,  A23L33/10 ,  A61K8/4973 ,  A61K31/336 ,  A61K2800/10 ,  A61Q19/00 ,  C07D303/32

Abstract: A method for producing a composition containing fucoxanthin includes a first step of adding a water-soluble solvent containing 0 to 80% by weight of water to seaweed to obtain a seaweed component extract, and then adding water and/or a water-soluble solvent to the seaweed component extract in such a manner that the concentration of the water-soluble solvent is 20 to 45% by weight and also adding a diluent thereto to obtain a diluent-containing extract, and a second step of stirring the diluent-containing extract, and then collecting a substance aggregating into the diluent-containing extract as a composition containing fucoxanthin by separation.

公开(公告)号：EP2423187A4

公开(公告)日：2015-08-12

申请号：EP09843676

申请日：2009-07-13

Applicant: KANEKA CORP

Inventor： KAWASAKI HIROAKI ,  MOROSHIMA TADASHI ,  MAEHARA KATSUJI ,  HIRAI YOSHINORI

IPC: C07C269/04 ,  C07C271/12

CPC classification number: C07C269/04 ,  C07C271/22

Abstract: A high quality N-alcoxycarbonyl-tert leucine can be efficiently and stably produced with an easy procedure by reacting tert-leucine with an N-alcoxycarbonylating agent in the presence of water, wherein the use amount of the N-alcoxycarbonylating agent is not less than 0.90 times by mole and not more than 1.00 times by mole relative to the tert-leucine, with maintaining the pH of the reaction mixture in the range of not less than 9 and not more than 13 using a basic agent. In addition, an N-alcoxycarbonyl-tert-leucine can be efficiently extracted from the basic aqueous solution thereof under a mild condition using a water-immiscible solvent by mixing a hydroxide. Furthermore, the two crystal forms of N-butoxycarbonyl-tert-leucine can be controlled by adjusting the water amount in crystallization step, and the compound can be stably produced in an industrial production.

公开(公告)号：EP2345733A4

公开(公告)日：2013-09-04

申请号：EP09823674

申请日：2009-10-29

Applicant: KANEKA CORP

Inventor： HIRAI YOSHINORI ,  MAEHARA KATSUJI ,  MOROSHIMA TADASHI ,  KANAMARU HIROYUKI ,  IWASAKI AKIRA

IPC: C12P13/04 ,  C07C69/04 ,  C12P13/06

CPC classification number: C12P13/06 ,  C07C269/04 ,  C12P13/04 ,  C07C271/22

Abstract: In the present invention, an N-protected amino acid is obtained by producing an amino acid using a biocatalyst such as a microorganism and enzyme; acidizing the reaction mixture containing the amino acid to adjust pH to not more than 4, without isolating the amino acid; and then protecting the amino group under a basic condition. As a result, a high-quality N-protected amino acid can be quantitatively and efficiently produced using a quantitative or slightly excessive protecting agent, even when the amino acid produced using a biocatalyst is directly protected without isolating the amino acid.