-
公开(公告)号：KR1020070118444A
公开(公告)日：2007-12-17
申请号：KR1020060052606
申请日：2006-06-12
Applicant: 신풍제약주식회사
CPC classification number: A61K9/2893 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K31/192 , A61K31/38
Abstract: A controlled-release formulation containing loxoprofen or zaltoprofen is provided to maintain effective concentration of drugs in blood for a long period of time by rapidly increasing blood concentration of active drug in an outer coating layer and slowly releasing the active drug in an inner core layer, thereby reducing an administration time. A controlled-release formulation contains a sustained-release inner core layer and a fast-release outer coating layer containing loxoprofen, zaltoprofen or its salts, respectively, wherein the sustained-release inner core layer contains an active ingredient and a matrix-forming agent and is coated by an enteric coating material, and the fast-release outer coating layer contains an active ingredient and strong disintegrant. The enteric coating material is cellulose ester derivatives, cellulose ether or acryl resin.
Abstract translation: 提供含有洛索洛芬或扎洛芬的控制释放制剂，以通过快速增加外部涂层中的活性药物的血液浓度并缓慢释放内核层中的活性药物来长时间维持药物在血液中的有效浓度， 从而减少给药时间。 缓释制剂包含分别含有洛索洛芬，唑洛芬或其盐的缓释内芯层和快速释放外涂层，其中缓释内芯层含有活性成分和基质形成剂， 被肠溶衣材料包覆，快速释放外涂层含有活性成分和强崩解剂。 肠溶衣材料是纤维素酯衍生物，纤维素醚或丙烯酸树脂。
-
公开(公告)号：KR100699457B1
公开(公告)日：2007-03-27
申请号：KR1020050066421
申请日：2005-07-21
Applicant: 신풍제약주식회사
IPC: C07D337/14
Abstract: 본 발명은 약학적 활성을 가지는 하기의 구조식 I의 화합물 2-(10,11-디히드로-10-옥소벤조[
b,f ]티에핀-2-일)프로피온산(이하, '구조식 I의 디벤조티에핀 유도체'라 칭한다) 및 그 중간체인 하기의 구조식 IV의 고리화된 할로케톤 화합물의 제조방법에 관한 것이다:
상기 식에서 X는 할로겐원자이다.
본 발명의 제조방법에 따르면 종래 방법에 비해 간단한 방법으로 약학적 활성을 가지는 구조식 I의 디벤조티에핀 유도체를 고순도 및 고수율로 제조할 수 있다.
디벤조티에핀 유도체, 소염진통작용, 고리화반응, 제조 수율-
公开(公告)号：KR1020070011824A
公开(公告)日：2007-01-25
申请号：KR1020050066421
申请日：2005-07-21
Applicant: 신풍제약주식회사
IPC: C07D337/14
Abstract: A method for preparing a dibenzothiepin derivative is provided to obtain the pharmaceutically active dibenzothiepin derivative with high purity and high yield through a simple process. The method for preparing a dibenzothiepin derivative represented by the formula(I) comprises the steps of: (a) reacting a propiophenone represented by the formula(II) with a halogenating agent to obtain a halo-ketone compound represented by the formula(III); (b) reacting the compound(III) with a condensing agent to obtain a cyclized halo-ketone compound represented by the formula(IV); (c) reacting the compound(IV) with an alkylorthoformate to obtain a cyclized haloacetal represented by the formula(V); (d) reacting the compound(V) with a zinc halide to obtain an ester compound represented by the formula(VI); and (e) hydrolyzing the compound(VI) to prepare the compound(I). In the formulae, X is halogen, and R1 is C1-6 alkyl, phenyl or phenyl having a substituent selected from the group consisting of H, halogen, C1-6 alkyl, and hydroxy.
Abstract translation: 提供了制备二苯并硫代衍生物的方法，以通过简单的方法获得高纯度和高产率的药物活性二苯并硫代衍生物。 制备由式（I）表示的二苯并硫代衍生物的方法包括以下步骤：（a）使由式（II）表示的苯丙酮酮与卤化剂反应，得到由式（III）表示的卤代酮化合物， ; （b）使化合物（III）与缩合剂反应，得到式（IV）所示的环化的卤代酮化合物; （c）使化合物（Ⅳ）与原甲酸烷基酯反应得到由式（Ⅴ）表示的环化的卤代缩醛; （d）使化合物（V）与卤化锌反应，得到式（VI）表示的酯化合物; 和（e）水解化合物（VI）以制备化合物（I）。 在该式中，X是卤素，R 1是C 1-6烷基，苯基或具有选自H，卤素，C 1-6烷基和羟基的取代基的苯基。
-
公开(公告)号：KR1020060039286A
公开(公告)日：2006-05-08
申请号：KR1020040088413
申请日：2004-11-02
Applicant: 신풍제약주식회사
IPC: A61K31/357
CPC classification number: A61K31/357 , A61K31/4375 , Y02A50/411 , A61K2300/00
Abstract: The present invention relates to an orally administrable antimalarial combined preparation containing artemisinine or its derivatives, and pyronaridine or its salts, as active ingredients, with pharmaceutically acceptable carriers, and to preparation process thereof.
-
公开(公告)号：KR100448469B1
公开(公告)日：2004-09-13
申请号：KR1020010066375
申请日：2001-10-26
Applicant: 신풍제약주식회사
Inventor： 이춘옥
IPC: A61K9/70
Abstract: PURPOSE: A composition of antiinflammatory agents or antiphlogistics for transdermal administration and an apparatus for transdermal administration thereof at a therapeutically effective speed are provided. The transdermal patch has nearly no irritation and good adhesion and shows desirable drug release properties and transdermal absorption and is thus useful for alleviation of the pain caused by swelling from rheumatoid arthritis, tendinitis, muscular pain, contusion, distortion, etc. CONSTITUTION: An apparatus(1) for transdermal administration of antiinflammatory agents or antiphlogistics comprises: a reservoir(3) containing a herapeutically effective amount of an anti-inflammatory agent mixed with a hydrophobic pressure-sensitive adhesive, a skin permeation-improving mixture and micronized water-swellable or hydro-attractants as an essential component; and a supporter(2) on the surface of a skin-proximal portion of the reservoir.
Abstract translation: 目的：提供了用于经皮给药的抗炎剂或消炎剂组合物和以治疗有效速度透皮给药的装置。 该透皮贴剂几乎没有刺激性和良好的粘附性，并显示出理想的药物释放特性和经皮吸收，因此可用于缓解由类风湿性关节炎，肌腱炎，肌肉疼痛，挫伤，变形等引起的疼痛所致的疼痛。组成： （1）用于经皮施用抗炎剂或消炎剂包含：储库（3），其含有与疏水性压敏粘合剂混合的治疗有效量的抗炎剂，皮肤渗透改善混合物和微粉化的水可溶胀或 水引诱剂作为重要组成部分; 和在储存器的皮肤近侧部分的表面上的支撑件（2）。
-
Patent Agency Ranking
公开(公告)号：KR100405161B1
公开(公告)日：2003-11-12
申请号：KR1020000076298
申请日：2000-12-14
Applicant: 신풍제약주식회사
IPC: A61K9/08
CPC classification number: A61K9/0019 , A61K31/192 , A61K47/02
Abstract: Disclosed is a formulation for intramuscular injection containingloxoprofen or a pharmaceutically acceptable salt thereof, having an excellent anti-inflammatory analgesic effect, as an active ingredient.
Abstract translation: 本发明公开了含有洛索洛芬或其药学上可接受的盐作为有效成分，具有优异的消炎镇痛作用的肌内注射用制剂。
-
公开(公告)号：KR1020010077337A
公开(公告)日：2001-08-17
申请号：KR1020000005071
申请日：2000-02-02
Applicant: 신풍제약주식회사
IPC: C07C229/00
Abstract: PURPOSE: An intermediate for preparing £2-(2,6-dichloroanilino)phenyl| acetoxyacetic acid (referred as "aceclofenac") used as an anti-inflammatory and analgesic agent, and methods for preparing aceclofenac are provided to improve production yield and purity without a process of waste heavy metal. CONSTITUTION: The intermediate which is used for preparing aceclofenac represented by the formula 1, is represented by the formula 2, wherein R1 and R2 are independent of each other and are an alkyl group of C1-C4. Aceclofenac is prepared by selectively hydrolyzing the intermediate of the formula 2 by using an acid in organic solvent. Preferably, the acid is HCl, H2SO4 or methanesulfonic acid; the solvent is alkyl acetate of C1-C5; and the reaction temperature is 20-40 deg.C. The intermediate of the formula 2 is prepared by reacting the alkali metal salt of compound of the formula 3 with the compound of the formula 4(X-CH2-COO-CH2OR¬1OR¬2) in solvent, wherein R1 and R2 are independent each other and are an alkyl group of C1-C4, and X is a halogen atom. Preferably X is Cl or Br; and the solvent is DMF or DMSO.
Abstract translation: 目的：制备2-（2,6-二氯苯胺基）苯基的中间体 用作抗炎和止痛剂的乙酰氧基乙酸（称为“醋氯芬酸”），以及制备醋氯芬酸的方法，以提高生产产率和纯度，而无需重金属废物。 构成：用于制备由式1表示的醋氯芬酸的中间体由式2表示，其中R 1和R 2彼此独立并且是C 1 -C 4的烷基。 通过在有机溶剂中使用酸选择性水解式2的中间体来制备醋氯芬酸。 优选地，酸是HCl，H 2 SO 4或甲磺酸; 溶剂是C1-C5的烷基乙酸酯; 反应温度为20-40℃。 式2的中间体通过使式3的化合物的碱金属盐与式4的化合物（X-CH 2 -COO-CH 2 OR 1 OR 2）在溶剂中反应制备，其中R 1和R 2各自独立地 另外是C1-C4的烷基，X是卤素原子。 优选地，X是Cl或Br; 溶剂为DMF或DMSO。
-
公开(公告)号：KR1019990025953A
公开(公告)日：1999-04-06
申请号：KR1019970047834
申请日：1997-09-19
Applicant: 신풍제약주식회사
Abstract: 본 발명은 구인(
Lumbricus rubellus ) 추출물(구인 동결건조분말)을 유효성분으로 함유하는 말초혈행장애 개선제 조성물에 관한 것이다. 더욱 구체적으로, 본 발명은 혈전형성 및 혈소판 응집 억제작용을 갖는 구인 추출물을 함유하여 뇌졸증, 동맥경화 및 고지혈증 등과 같은 순환기계 질환의 합병증인 말초혈행장애를 효과적으로 개선시킬 수 있는 조성물에 관한 것이다.-
公开(公告)号：KR100137259B1
公开(公告)日：1998-04-25
申请号：KR1019930014717
申请日：1993-07-30
Applicant: 신풍제약주식회사
Abstract: 본 발명은 구인 (Lubricus rucellus)을 자기분해시키고, 그 용액을 동결과 해빙을 반복하여 분순물을 침전 시킨후, 원심분리를 행하고 얻어진 상등액을 동결건조하여 구인 추출 건조분말을 제로하는 방법에 관한 것이다.
또한 본 발명은 상기의 원심분리를 행하고 얻어진 상등액을 규조토 및 제균 필터로 여과하고 동결건조하는 방법에 관한 것이다. -
-
-
-
-
-
-
-
-
Search Results
84
records
(took 0.025 seconds)
