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公开(公告)号：KR1020040101787A
公开(公告)日：2004-12-03
申请号：KR1020030033541
申请日：2003-05-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: PURPOSE: Provided is a method for preparing biodegradable porous polymer support for tissue engineering without organic solvent, which is used for regeneration of tissue and excellent in stability. CONSTITUTION: The porous polymer support for tissue engineering is prepared by mixing polymer powder and water soluble salts uniformly; pressing the resulting mixture in mold; jointing the obtained press molding while heating; and removing the water soluble salts from the molding. The polymers are biodegradable polymers selected from the group consisting of polylactide, polyglycolide, polycaprolactone, polytrimethylene carbonate, polyamino acid, polyorthoester, polyethylene oxide and copolymer thereof. The polymers are also nondegradable polymers selected from the group consisting of polyurethane, polyethylene and polycarbonate. The support has the porosity of 50 to 99%. And the pores in the support have the size of 1 to 800 micrometers.
Abstract translation: 目的：提供无有机溶剂组织工程生物降解多孔聚合物载体的方法，用于组织再生和稳定性好。 构成：通过将聚合物粉末和水溶性盐均匀混合制备用于组织工程的多孔聚合物载体; 将所得混合物压在模具中; 在加热时将获得的压模连接; 并从模塑中除去水溶性盐。 聚合物是选自聚丙交酯，聚乙交酯，聚己内酯，聚三亚甲基碳酸酯，聚氨基酸，聚原酸酯，聚环氧乙烷及其共聚物的生物可降解聚合物。 聚合物也是选自聚氨酯，聚乙烯和聚碳酸酯的不可降解聚合物。 载体的孔隙率为50〜99％。 并且支撑体中的孔具有1至800微米的尺寸。
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公开(公告)号：KR1020040065348A
公开(公告)日：2004-07-22
申请号：KR1020030002289
申请日：2003-01-14
Applicant: 한국과학기술연구원
IPC: C07C309/21
Abstract: PURPOSE: Provided are a vinyl monomer comprising sulfonated poly(ethylene oxide), its polymer which shows excellent antithrombotic property and can be applied as a material of medical instrument, and a method for preparing the monomer and the polymer. CONSTITUTION: The vinyl monomer is represented by formula 1: CH2=CR-X-NH-A-O-(CH2-CH2-O)n-B-NH-(CH2)3-SO3H(wherein R is -H or CH3, X is -CO-, -CO-O-CH2-CH2-NH-CO-, -CH2-NH-CO- or -CH2, -O-CHOH-CH2-, -A- and -B-, which are same or different, represent -(CH2)-m-, m is 2 or 3, n is 100-200). The vinyl monomer is prepared by the method comprising replacing only amino group at one end of poly(ethylene oxide)(PEO) having both ends substituted with amino group, with sulfonic acid group, and reacting an amino group at the other end of PEO with vinyl compound having vinyl group.
Abstract translation: 目的：提供包含磺化聚（环氧乙烷）的乙烯基单体，其聚合物显示出优异的抗血栓形成性质并且可以用作医疗器械的材料，以及制备单体和聚合物的方法。 构成：乙烯基单体由式1表示：CH2 = CR-X-NH-AO-（CH2-CH2-O）nB-NH-（CH2）3-SO3H（其中R是-H或CH3，X是 - CO-，-CO-O-CH2-CH2-NH-CO-，-CH2-NH-CO-或-CH2，-O-CHOH-CH2-，-A-和-B-，它们相同或不同， 表示 - （CH 2）m - ，m为2或3，n为100-200）。 乙烯基单体通过以下方法制备，该方法包括仅将两端用氨基取代的聚（环氧乙烷）（PEO）的一端与磺酸基取代，并将PEO另一端的氨基与 具有乙烯基的乙烯基化合物。
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公开(公告)号：KR1020010038098A
公开(公告)日：2001-05-15
申请号：KR1019990045940
申请日：1999-10-22
Applicant: 한국과학기술연구원
IPC: A61F2/10
Abstract: PURPOSE: A bioprosthetic tissue implants and a method for preparing the same are provided in which antithrombotic and particularly calcification resistance are substantially improved by chemically bonding heparin with bioprosthetic tissue. CONSTITUTION: The method for preparing the calcification resistance bioprosthetic tissue implants comprises the step of chemically covalent bonding heparin with the crosslinked bioprosthetic tissue after crosslinking the bioprosthetic tissue obtained from human or animal with glutaraldehyde, wherein the bioprosthetic tissue obtained from human or animal is tissue heart valve, pericardium or dura mater, wherein the heparin is a low molecular weight heparin having a molecular weight of 2000 to 5000, or a high molecular weight heparin having a molecular weight of 7000 to 20000, the heparin that is oxidized and partially decomposed is used in an amount of a solution of 0.05 to 20%, wherein the glutaraldehyde is used in an amount of a solution of 0.05 to 1.5%, and wherein the method further comprises the step of reduction reacting the heparin bonded bioprosthetic tissue with sodium borohydride after the chemical bonding step of the heparin with the crosslinked bioprosthetic tissue.
Abstract translation: 目的：提供生物假体组织植入物及其制备方法，其中通过用生物假体组织化学键合肝素来显着改善抗血栓形成和特别是耐钙化性。 构成：用于制备耐钙化生物假体组织植入物的方法包括在用戊二醛交联从人或动物获得的生物假体组织交联生物假体组织之后，将肝素与交联的生物假体组织化学共价键合的步骤，其中从人或动物获得的生物假体组织是组织心脏 瓣膜，心包或硬脑膜，其中肝素是分子量为2000〜5000的低分子量肝素或分子量为7000〜20000的高分子量肝素，使用被氧化并部分分解的肝素 其量为0.05〜20％的溶液，其中所述戊二醛的使用量为0.05〜1.5％的溶液，其中所述方法还包括使所述肝素结合的生物假体组织与硼氢化钠反应的步骤 肝素与交联的生物假体组织的化学键合步骤。
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公开(公告)号：KR100280352B1
公开(公告)日：2001-02-01
申请号：KR1019980016277
申请日：1998-05-07
IPC: C08F8/00
Abstract: 본 발명은 인공 고관절의 아세테뷸라 컵(acetabular cup)과 인공 무릎관절의 아티큘라 플레이트(articular plate)용 재질인 초고분자량 폴리에틸렌과 접착제인 폴리메틸메타크릴레이트 골시멘트와의 접착력을 증가시키기 위한 초고분자량 폴리에틸렌의 표면 개질 방법에 있어서, 초고분자량 폴리에틸렌에 메틸메타크릴레이트, 메타크릴산, 아크릴산 또는 이들의 혼합물로 이루어진 군으로부터 선택된 단량체를 방사선으로 그라프트시키는 것을 특징으로 하는 표면 개질 방법에 관한 것이다.
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Patent Agency Ranking
公开(公告)号：KR1019980066242A
公开(公告)日：1998-10-15
申请号：KR1019970001635
申请日：1997-01-21
Applicant: 한국과학기술연구원 , 안국바이오진단(주)
IPC: A61F2/00
Abstract: 생체 조직에 혈액 적합성, 생체내 안정성 및 항석회화 특성을 지닌 술폰화 폴리에틸렌 옥사이드 유도체를 화학적 개질 방법으로 공유 결합시켜 제조되는 장시간 사용 가능하고 석회화가 월등히 적은 생체 조직 이식물 및 그의 제조 방법이 기재되어 있다.
본 발명의 개질 방법에 따라 술폰화 폴리에틸렌 옥사이드 유도체를 생체 조직에 결합시킬 경우 혈액 적합성, 생체내 안정성 및 항석회화 특성을 가질 뿐만 아니라 콘드로이틴황산염과 같은 음이온 효과, 공간 충진 효과 및 칼슘 침착 유도 인자 중의 하나로 알려진 콜라겐의 카르복시기를 블로킹하는 효과 등의 상승 작용을 기대할 수 있다. 또한, 본 발명의 방법은 혈전증과 색전증을 억제하고 그 감염도 줄일 수 있기 때문에 석회화 억제 방법으로 더욱 유리하다. 본 발명에 따라 개질된 생체 조직은 생체내 석회화 동물 시험에서 칼슘 침착량의 분석 결과, 술폰화 폴리에틸렌 옥사이드 미함유 대조군에 비하여 매우 적은 값을 나타내어 월등히 개선된 항석회화 특성을 갖고 있음이 입증되었다. 따라서, 본 발명에 의하여 개질된 생체 조직은 생체 조직 이식물로서 이식 후 장기간 사용될 수 있다.-
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公开(公告)号：KR1019950010146B1
公开(公告)日：1995-09-11
申请号：KR1019920018282
申请日：1992-10-06
Applicant: 한국과학기술연구원 , 재단법인대한치주연구소
IPC: A61K9/70
Abstract: The patch for treating a stomatitis is produced by (a) adding a steroidic antiphlogistic to a mixed solution obtd. by dissolving a citric acid into a glycerin, and suspending the mixture, (b) adding a hydrophilic polymer to the suspension to obtain a viscous polymer mixture, (c) casting the mixture on the release liner of a silicone paper to form an even film, (d) heating the film to to crosslink-coupling the polymer, and (e) coating a non-permeable supporting film on the matrix layer of the linear/ matrix composite layer. The steroidic antiphlogistic is pref. triamcinolone acetonide, and the hydrophilic polymer is pref. karaya gum, arabia gum, carboxymethyl cellulose, hydroxymethyl cellulose or polyacrylic acid.
Abstract translation: 用于治疗口炎的贴剂通过（a）向混合溶液中加入类固醇消炎药而产生。 通过将柠檬酸溶解到甘油中并使混合物悬浮，（b）向悬浮液中加入亲水性聚合物以获得粘性聚合物混合物，（c）将该混合物浇注在硅酮纸的剥离衬垫上以形成均匀的膜 （d）将膜加热以使聚合物交联耦合，和（e）在线性/基质复合层的基质层上涂覆不可渗透的支撑膜。 类固醇消炎药是优先的。 曲安奈德，亲水性聚合物是优选的。 刺梧桐树胶，阿拉伯胶，羧甲基纤维素，羟甲基纤维素或聚丙烯酸。
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公开(公告)号：KR1019940003863B1
公开(公告)日：1994-05-04
申请号：KR1019910000095
申请日：1991-01-07
Applicant: 한국과학기술연구원
IPC: C08G18/02
CPC classification number: C08G18/83 , A61L33/0076 , C08G18/10 , C08L75/04 , Y10S623/921 , C08G18/2885
Abstract: Novel modified polymeric materials are provided. The polymeric materials according to the invention are prepared by grafting a fluorine-containing compound onto a polyurethane polymeric substrate. The polymeric materials show superior blood compatibility in the in vitro and ex vivo tests, attributing to hydrophobic property, inertness and water-repelling property intrinsic to the grafted fluorine containing compounds. The polymeric materials according to the invention are useful as the materials for the artificial, circulatory, internal organ systems to be contacted with blood, such as artificial hearts, artificial blood vessels, artificial heart valves, artificial blood oxygenators, and artificial kidneys, or for the medical devices/instruments to be inserted into the blood vessels, such as vein catheters, artery catheters and intra-aortic balloon pumps.
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