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公开(公告)号：KR101111247B1
公开(公告)日：2012-06-12
申请号：KR1020090065466
申请日：2009-07-17
Applicant: 한국과학기술연구원
IPC: C07D231/04 , C07D231/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: 본 발명은 신규 피라졸 화합물과 약제학적으로 허용 가능한 이의 염, 이 화합물의 제조방법, 그리고 이 화합물을 항암제로 사용하는 의약용도에 관한 것이다.
피라졸 화합물, 리셉터 타이로신 카이나제, Ros 단백질 저해제, 뇌암, 다형성 교아종, 항암제-
公开(公告)号：KR1020110051579A
公开(公告)日：2011-05-18
申请号：KR1020090108221
申请日：2009-11-10
Applicant: 한국과학기술연구원
CPC classification number: B05D7/14 , A61L27/00 , A61L27/28 , A61L27/34 , A61L31/10 , A61L2400/12 , A61L2400/18 , B05D1/18 , B05D3/142 , Y10T428/273 , Y10T428/31678 , C08L67/04
Abstract: PURPOSE: A method for manufacturing a surface-modified metal substrate is provided to simplify process and to reduce production cost. CONSTITUTION: A surface-modified metal substrate contains a metal substrate and polymer layer which is chemically conjugated to the surface through oxygen atoms. A method for manufacturing the surface-modified metal substrate comprises: a step of introducing a hydroxy group to the surface of the metal substrate; a step of polymerizing monomers on the surface to chemically bind polymers onto the surface through oxygen atoms. The metal is selected from stainless steel, covalt-chrome, titanium, nitinol, gold, silver, platinum, tantalum, magnesium, and metal alloy thereof.
Abstract translation: 目的：提供一种制造表面改性金属基材的方法，以简化工艺并降低生产成本。 构成：表面改性的金属基材含有金属基材和通过氧原子与表面化学偶合的聚合物层。 制造表面改性金属基材的方法包括：将羟基引入金属基材的表面的步骤; 在表面上聚合单体以通过氧原子将聚合物化学结合到表面上的步骤。 金属选自不锈钢，钴铬，钛，镍钛诺，金，银，铂，钽，镁及其金属合金。
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公开(公告)号：KR1020110023399A
公开(公告)日：2011-03-08
申请号：KR1020090081256
申请日：2009-08-31
Applicant: 한국과학기술연구원
CPC classification number: A61L24/106 , A61L24/0015 , A61L24/04 , A61L24/08 , A61L33/126
Abstract: PURPOSE: An intelligent fibrin bio-adhesive with superior hemostasis effect and mechanical properties is provided to obtain an anti-bacteria property by adding natural polymer and/or antibiotics. CONSTITUTION: Fibrin and natural polymer form crosslinkage, and interpenetrating network or semi-interpenetrating network is obtained. The natural polymer is one or more selected from a group including alginate, chitosan, chitin, cellulose, agarose, amylase, dextran, proteoglycan, glycosaminoglycan, collagen, gelatin, heparin, hyaluronic acid, pectin, carrageena, chondroitin sulfate, dextran sulfate, polylysine, pullulan, carboxylmethyl chitin, and the salt of the same. Antibiotics are additionally introduced into the interpenetrating network or the semi-interpenetrating network.
Abstract translation: 目的：提供具有优异止血效果和机械性能的智能纤维蛋白生物粘合剂，通过加入天然聚合物和/或抗生素获得抗细菌性能。 构成：纤维蛋白和天然聚合物形成交联，获得互穿网络或半互穿网络。 天然聚合物是选自藻酸盐，壳聚糖，壳多糖，纤维素，琼脂糖，淀粉酶，葡聚糖，蛋白聚糖，糖胺聚糖，胶原，明胶，肝素，透明质酸，果胶，角叉菜胶，硫酸软骨素，硫酸葡聚糖，聚赖氨酸 ，支链淀粉，羧甲基甲壳质及其盐。 抗生素还被引入到互穿网络或半互穿网络中。
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公开(公告)号：KR1020110007830A
公开(公告)日：2011-01-25
申请号：KR1020090065466
申请日：2009-07-17
Applicant: 한국과학기술연구원
IPC: C07D231/04 , C07D231/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: PURPOSE: A novel pyrazole compound I provided to ensure excellent activity on ROS kinase enzyme and to suppress development of glioblastoma multiforma, CNS cancer, and brain cancer. CONSTITUTION: A pyrazole compound is denoted by chemical formula 1. A pharmaceutical composition for anti-cancer contains the pyrazole compound. An anticancer agent contains the pyrazole compound as an active ingredient. The anticancer agent is used for treating brain cancer, CNS caner, and glioblastoma multiforma. A method for preparing the pyrazole compound comprises: a step of reacting a hetero aromatic compound of chemical formula 3 with methyl 3-methoxy-5-methoxybenzoate compound of chemical formula 2 under the presence of lithium hexamethyldisilazide(LHMDS) to obtain a keto-enol tautomer compound; and a step of reacting the keto-enol tauotmer compound with hydrazine hydrate under anhydrous ethanol condition.
Abstract translation: 目的：提供一种新的吡唑化合物I，以确保对ROS激酶的优异活性，并抑制多形性胶质母细胞瘤，CNS癌和脑癌的发展。 构成：吡唑化合物由化学式1表示。用于抗癌的药物组合物含有吡唑化合物。 抗癌剂含有吡唑化合物作为活性成分。 抗癌剂用于治疗脑癌，CNS癌和多形性成胶质细胞瘤。 制备吡唑化合物的方法包括：使化学式3的杂芳族化合物与化学式2的3-甲氧基-5-甲氧基苯甲酸甲酯在六甲基二硅叠氮化锂（LHMDS）存在下反应，得到酮 - 烯醇 互变异构体 以及在无水乙醇条件下使酮 - 烯醇葡聚糖化合物与水合肼反应的步骤。
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公开(公告)号：KR1020100077770A
公开(公告)日：2010-07-08
申请号：KR1020080135808
申请日：2008-12-29
Applicant: 한국과학기술연구원
CPC classification number: A61L31/16 , A61L31/10 , A61L31/14 , A61L31/148 , A61L2300/61 , A61L2400/12 , A61L2400/18 , A61F2/82 , A61L27/34 , A61L27/54 , C08L67/04
Abstract: PURPOSE: A method of manufacturing a medical stent for releasing medical drugs and a medical stent for releasing medical drugs using the same method are provided, which have the nano-structured pattern using the plasma-assisted chemical vapor deposition. CONSTITUTION: A method of manufacturing medical stent for releasing medical drug having the nano-structured pattern includes: a step of coating the surface of stent with the biodegradable polymer; a step of forming the nano-structured pattern on the surface of the stent coated with the biodegradable polymer through the ion beam or the plasma process using the method of plasma-assisted chemical vapor deposition; and a step of dipping the medical drugs within the biodegradable polymer in which the nano-structured pattern is formed. The biodegradable polymer is the biodegradable polymer in which the medical drugs are dipped.
Abstract translation: 目的：提供一种使用等离子体辅助化学气相沉积制造具有纳米结构图案的用于使用相同方法制造用于释放药物的医用支架和用于释放药物的药物支架的方法。 构成：制造具有纳米结构图案的医药用医用支架的方法，其特征在于，包括以下步骤：用生物降解性聚合物涂布支架表面; 使用等离子体辅助化学气相沉积的方法通过离子束或等离子体处理在涂覆有可生物降解的聚合物的支架的表面上形成纳米结构图案的步骤; 以及将药物浸渍在其中形成纳米结构图案的生物可降解聚合物中的步骤。 可生物降解的聚合物是医用药物浸渍的可生物降解的聚合物。
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Patent Agency Ranking
公开(公告)号：KR100794174B1
公开(公告)日：2008-01-14
申请号：KR1020060113227
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.
Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。
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公开(公告)号：KR100752100B1
公开(公告)日：2007-08-27
申请号：KR1020060104844
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A cardiovascular system transplanting metallic material is provided to improve blood compatibility by modifying the surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative having anions. A metallic material has improved blood compatibility by modifying a surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative of the formula 1, X-R1-PEG-R1-Y, where R1 is one or more functional groups connected by urethane, urea, amide, ester, ether or anhydride comprising 0 to 20 alkyl groups or aryl groups; X is -NCO or -CHO; and Y is sulfobetaine(-N^+ -R2 -SO3^-) as a zwitterionic derivative, wherein R2 is an alkyl group or an aryl group. A manufacturing method of a metallic material of which surface is modified with a sulfobetaine poly(ethylene glycol) derivative comprises the steps of: oxidizing the surface of the metallic material to introduce a hydroxyl group(-OH) into the surface thereof; and chemically bonding the sulfobetaine poly(ethylene glycol) derivative to the hydroxyl group of the metallic material surface.
Abstract translation: 提供心血管系统移植金属材料以通过用具有阴离子的磺基甜菜碱聚（乙二醇）衍生物修饰金属材料的表面来改善血液相容性。 金属材料通过用式1的磺基甜菜碱聚（乙二醇）衍生物X-R1-PEG-R1-Y对金属材料的表面进行改性来改善血液相容性，其中R1是通过氨基甲酸酯连接的一个或多个官能团 ，包含0至20个烷基或芳基的脲，酰胺，酯，醚或酸酐; X是-NCO或-CHO; 并且Y是磺基甜菜碱（-N ^ + -R 2 -SO 3 - ） - 作为两性离子衍生物，其中R 2是烷基或芳基。 其表面用磺基甜菜碱聚（乙二醇）衍生物改性的金属材料的制造方法包括以下步骤：氧化金属材料的表面以将羟基（-OH）引入其表面; 并将磺基甜菜碱聚（乙二醇）衍生物化学结合到金属材料表面的羟基上。
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公开(公告)号：KR100518998B1
公开(公告)日：2005-10-06
申请号：KR1020030060180
申请日：2003-08-29
IPC: A61K6/08
Abstract: 본 발명은 물리적, 기계적 특성 및 생체 적합성이 개선된 치과용 자가중합형 레진시멘트 조성물에 관한 것으로, 보다 구체적으로는 2,2-비스[4-(2-히드록시-3-메타크릴옥시프로폭시)페닐]프로판 (이하 "Bis-GMA로 칭함)과 Bis-GMA에 존재하는 히드록시기 (-OH)가 메타크릴레이트기로 치환된 멀티메타크릴레이트기 함유 다관능성 프리폴리머를 혼합한 프리폴리머 혼합물, 희석제, 접착 단량체, 중합개시제, 중합금지제, 광안정제, 산화방지제, 무기 안료 및 무기 충전재가 혼합된 페이스트(paste) A 조성물과, 상기 페이스트 A 조성물의 프리폴리머 혼합물과 동일한 프리폴리머 혼합물, 희석제, 접착 단량체, 환원제, 중합금지제, 광안정제, 산화방지제, 무기 안료 및 무기 충전재가 혼합된 페이스트 B 조성물로 구성된 치과용 자가중합형 레진시멘트 조성물에 관한 것이 다.
발명의 치과용 자가중합형 레진시멘트는 종래의 자가중합형 레진시멘트보다 우수한 물리적, 기계적 특성 및 생체 적합성을 나타내며, 연고-연고형 시스템으로서 사용이 간편하다.-
公开(公告)号：KR1020050023109A
公开(公告)日：2005-03-09
申请号：KR1020030060180
申请日：2003-08-29
IPC: A61K6/08
Abstract: PURPOSE: A composition of dental self-curing resin cements is provided, which composition is ointment-ointment system of which usage is convenient, and has improved fluidity, low polymerization contraction rate, low water absorption, low water solubility and low viscosity, so that the amount of an added diluting agent can be reduced and a large amount of inorganic filler can be mixed. CONSTITUTION: The composition of dental self-curing resin cements comprises a paste composition A comprising 1 to 25 wt.% of prepolymer mixture, 1 to 20 wt.% of diluting agent, 0.1 to 15 wt.% of adhesive monomer, 0.1 to 3 wt.% of polymerization initiator, 0.1 to 3 wt.% of polymerization inhibitor, 0.1 to 2 wt.% of photo-stabilizing agent, 0.1 to 2 wt.% of oxidation inhibitor, 0.005 to 1 wt.% of inorganic dye, and inorganic filler; and a paste composition B comprising 1 to 25 wt.% of prepolymer, 1 to 20 wt.% of diluting agent, 0.1 to 15 wt.% of adhesive monomer, 0.1 to 3 wt.% of reducing agent, 0.1 to 3 wt.% of polymerization inhibitor, 0.1 to 2 wt.% of photo-stabilizing agent, 0.1 to 2 wt.% of oxidation inhibitor, 0.005 to 1 wt.% of inorganic dye and inorganic filler, wherein the prepolymer is selected from 2,2-bis£4-(2-hydroxy-3-methacryloxypropoxy)phenyl|propane (Bis-GMA) of formula (1), Tri-GMA of formula (2), a mixture of Bis-GMA and Tetra-GMA of formula (3), and a mixture of Bis-GMA, Tri-GMA and Tetra-GMA.
Abstract translation: 目的：提供牙科自固化树脂水泥的组合物，其组成为使用方便的软膏系统，流动性好，聚合收缩率低，吸水率低，水溶性低，粘度低，因此 可以减少添加的稀释剂的量，并且可以混合大量的无机填料。 构成：牙科自固化树脂水泥的组成包括糊组合物A，其包含1至25重量％的预聚物混合物，1至20重量％的稀释剂，0.1至15重量％的粘合剂单体，0.1至3 聚合引发剂的重量百分数，聚合抑制剂的0.1〜3重量％，光稳定剂0.1〜2重量％，氧化抑制剂0.1〜2重量％，无机染料0.005〜1重量％ 无机填料; 和含有1〜25重量％预聚物，1〜20重量％稀释剂，0.1〜15重量％粘合剂单体，0.1〜3重量％还原剂，0.1〜3重量％ ％的阻聚剂，0.1〜2重量％的光稳定剂，0.1〜2重量％的氧化抑制剂，0.005〜1重量％的无机染料和无机填料，其中预聚物选自2,2-二 式（1）的双4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基|丙烷（Bis-GMA），式（2）的三-GMA，式（3）的Bis-GMA和四-GMA的混合物 ）和Bis-GMA，Tri-GMA和Tetra-GMA的混合物。
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公开(公告)号：KR1020030018325A
公开(公告)日：2003-03-06
申请号：KR1020010051994
申请日：2001-08-28
Applicant: 한국과학기술연구원 , 주식회사 티씨 싸이언스
IPC: C08J7/18
Abstract: PURPOSE: A method for preparing a soft lens is provided to obtain an unharmful soft lens for inhibiting the adsorption of proteins, thereby improving the wearing feeling and the lifetime of the lens. CONSTITUTION: The method comprises the steps of treating the surface of a contact lens with plasma to activate the surface; and grafting the protein adsorption inhibiting material represented by the formula 1 onto the surface, wherein R1 is H or methyl group; and R2 is polyethylene glycol, polypropylene glycol, polyethylene glycol-polypropylene glycol copolymer, polyethylene glycol-polypropylene glycol-polyethylene glycol copolymer, poly(vinyl pyrrolidone), their copolymers or their mixtures. The protein adsorption inhibiting material has a molecular weight of 100-10,000. Preferably the plasma treatment is carried out by using the plasma of 1 W to 1 kW; and the grafting is carried out at a temperature of 10-100 deg.C and in the presence of sodium hydrogensulfite as an oxidizing agent.
Abstract translation: 目的：提供一种制备软透镜的方法，以获得抑制蛋白质吸附的不好的软透镜，从而提高透镜的穿戴感和使用寿命。 构成：该方法包括用等离子体处理隐形眼镜表面以激活表面的步骤; 并将由式1表示的蛋白质吸附抑制物质接枝到表面上，其中R1是H或甲基; R2是聚乙二醇，聚丙二醇，聚乙二醇 - 聚丙二醇共聚物，聚乙二醇 - 聚丙二醇 - 聚乙二醇共聚物，聚（乙烯基吡咯烷酮），它们的共聚物或它们的混合物。 蛋白质吸附抑制物质的分子量为100〜10000。 优选地，通过使用1W至1kW的等离子体来进行等离子体处理; 接枝在10-100℃的温度下进行，在亚硫酸氢钠存在下作为氧化剂进行。
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