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    신규한 벤조피란계 히드록시메틸화 대사산물 및 유도체
    71.
    发明授权
    신규한 벤조피란계 히드록시메틸화 대사산물 및 유도체 失效
    新型苯并吡喃类羟甲基化代谢物和衍生物

    公开(公告)号：KR1019960015006B1

    公开(公告)日：1996-10-23

    申请号：KR1019930008366

    申请日：1993-05-15

    Applicant: 한국화학연구원

    Inventor： 유성은 ,  서지희 ,  김선주

    IPC: C07D405/04

    Abstract: This invention relates to the pharmaceutical composite containing benzopyran group hydroxylmethyl metabolite or its derivatives useful to reduce blood pressure wherein the benzopyran derivatives having following formula(I). In the formula, R1 is -CN, -NO2, OCX1X2X3, NH2, -NHSO2Ra, -NHCORb, -CONRcRd, -SO2Rc or -SO2NRcRd wherein X1, X2 and X3 are separate F, Cl or H; Ra and Rb are separate amino, C1-6 alkoxyl, C1-6 alkyl or phenyl; Rc and Rd are separate halogen, C1-6 alkyl or replaced/or not replaced phenyl; R2 is like the formula where Re is C1-6 alkyl, cyclopropyl, cyclopropyl methyl or benzyl; Rf is -CORa or -CSRa, X is O, S or NRc, and Y is H, C1-6 linear or side chain alkyl, halogen, amino or C16 alkoxy, and n is between 0 and 3; R3 is replaced or not replaced C1-4 linear or side chain alkyl.

    Abstract translation: 本发明涉及含有苯并吡喃基羟甲基代谢物或其衍生物的药物复合物，其用于降低血压，其中具有下式（I）的苯并吡喃衍生物。 式中，R1为-CN，-NO2，OCX1X2X3，NH2，-NHSO2Ra，-NHCORb，-CONRcRd，-SO2Rc或-SO2NRcRd，其中X1，X2和X3分别为F，Cl或H; R a和R b分别是氨基，C 1-6烷氧基，C 1-6烷基或苯基; Rc和R d分别是卤素，C 1-6烷基或被取代的或未被取代的苯基; R 2如下式，其中Re为C 1-6烷基，环丙基，环丙基甲基或苄基; Rf为-CORa或-CSRa，X为O，S或NRc，Y为H，C1-6直链或侧链烷基，卤素，氨基或C16烷氧基，n为0至3; R3被取代或未被C 1-4直链或侧链烷基取代。

    벤조피란 유도체와 그의 제조방법
    73.
    发明授权
    벤조피란 유도체와 그의 제조방법 失效
    苯并吡喃衍生物及其制备方法

    公开(公告)号：KR1019950009863B1

    公开(公告)日：1995-08-29

    申请号：KR1019910024353

    申请日：1991-12-26

    Applicant: 한국화학연구원

    Inventor： 유성은 ,  정낙철 ,  서지희 ,  김선주

    IPC: C07D405/04

    CPC classification number: C07D405/04 ,  C07D405/14

    Abstract: The cpd. of formula (I-a) is prepd. by (a) reacting ketone derivatives of formula (II) with trifluorosulfonic acid anhydride and ter-amine, or making the ketone derivatives (II) to enolate with a base and then reacting N-phenyl trifluoromethane sulfonimide to convert to the vinyl triflate derivs. of formula (III); and (b) reacting the derivs. (III) with trialkyline derivs. of formula (IV). In the formulas, R1 is -CN, -NO2, -OCX1X2X3 or -SO2Rc; X1, X2, and X3 are F, Cl or H(however, X1=X2=X3=H); R2 is straight or branched C1-4 alkyl; R3 is straight or branched C1-4 alkyl, etc; R4 is C1-4 alkyl.

    Abstract translation: cpd。 的式（I-a）是制备的。 通过（a）使式（II）的酮衍生物与三氟磺酸酐和三胺反应，或使酮衍生物（II）与碱烯醇化，然后使N-苯基三氟甲磺酰亚胺反应转化成三氟甲磺酸乙烯酯衍生物。 的式（III）; 和（b）使衍生物反应。 （III）与三烷基衍生物。 的式（IV）化合物。 式中，R 1为-CN，-NO 2，-OCX 1 X 2 X 3或-SO 2 R c; X1，X2和X3分别为F，Cl或H（但X1 = X2 = X3 = H）; R2是直链或支链C 1-4烷基; R3是直链或支链C 1-4烷基等; R4是C1-4烷基。

    벤조피란 유도체와 그의 제조방법(1)
    74.
    发明授权
    벤조피란 유도체와 그의 제조방법(1) 失效
    苯并吡喃衍生物及其制备方法

    公开(公告)号：KR1019950009862B1

    公开(公告)日：1995-08-29

    申请号：KR1019910024352

    申请日：1991-12-26

    Applicant: 한국화학연구원

    Inventor： 유성은 ,  이규양 ,  정낙철 ,  서지희 ,  김선주 ,  신화섭 ,  이병호 ,  정규식

    IPC: C07D405/04

    CPC classification number: C07D405/04 ,  C07D405/14

    Abstract: Benzopyran derivatives of formula (I) are prepd. by (a) reacting the epoxy cpd. of formula (II) with a nucleophilic agent contg. cpd. to prepare the alcohol dervs. of formula (III), in the presence of a base; (b) dehydration reacting the cpd. (III) in the presence of a base. In the formulas, R1 is -CN, -NO2, OCX1X2X3 or -SO2Rc; X1, X2 and X3 are eachly F, Cl or H; Rc is H, C1-6 alkyl or opt. satd. phenyl where satd. gp. is halogen, or straight or branched C1-3 alkyl. The obptd. benzopyran dervs. are useful for curing hypertension.

    Abstract translation: 式（I）的苯并吡喃衍生物是制备的。 通过（a）使环氧树脂cpd反应。 的式（II）与亲核剂 CPD。 准备酒精dervs。 在式（III）的存在下， （b）使cpd反应脱水。 （III）在碱的存在下。 式中，R 1为-CN，-NO 2，OCX 1 X 2 X 3或-SO 2 R c; X1，X2和X3分别为F，Cl或H; Rc是H，C 1-6烷基或选择。 饱和。 苯基，其中satd GP。 是卤素，或直链或支链C 1-3烷基。 绝对的 苯并吡喃衍生物 可用于治疗高血压。

    벤즈옥사졸릴피리다지논 유도체와 그의 제조방법
    80.
    发明授权
    벤즈옥사졸릴피리다지논 유도체와 그의 제조방법 失效
    苯并恶唑基哒嗪酮衍生物及其制备方法

    公开(公告)号：KR1019910003187B1

    公开(公告)日：1991-05-22

    申请号：KR1019890003577

    申请日：1989-03-22

    Applicant: 한국화학연구원

    Inventor： 유성은 ,  서지희

    IPC: C07D413/14 ,  C07D413/04

    Abstract: Benzoxazolyl pyridazinone derivs. of formlula (I) are prepared. In (I), R= H, C1-6 alkyl, cyclic alkyl or substd. phenyl; X= halogen atom, nitor gp., -R1, -OR1, -NR1R2 or -SR1; n= 1- 5; R1 and R2 each = H, C1-6 alkyl, cyclic alkyl or substd. phenyl; A= C or N. (I) are useful as cardiotonics for enhancing contractile force of cardiac mluscle, and (I) have antihypertensive activities.

    Abstract translation: 苯并恶唑哒嗪酮衍生物。 的制剂（I）。 在（I）中，R = H，C 1-6烷基，环烷基或取代基。 苯基; X =卤素原子，nitor gp，-R1，-OR1，-NR1R2或-SR1; n = 1-5; R1和R2各自为H，C1-6烷基，环烷基或取代基。 苯基; A = C或N.（I）可用作增强心脏肌肉收缩力的强心剂，（I）具有抗高血压活性。

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