公开(公告)号：HK1150607A1

公开(公告)日：2012-01-06

申请号：HK11104718

申请日：2011-05-13

Applicant: ARRAY BIOPHARMA INC

Inventor： MARLOW ALLISON L ,  YANG HONG WOON ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  WALLACE ELI ,  BLAKE JIM

IPC: C07D20060101 ,  A01N33/02 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/64 ,  A01N43/90 ,  A61K20060101 ,  A61K31/40 ,  A61K31/415 ,  A61K31/416 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/655 ,  A61P20060101 ,  C07D209/44 ,  C07D209/46 ,  C07D213/80 ,  C07D213/82 ,  C07D215/48 ,  C07D221/04 ,  C07D231/56 ,  C07D237/24 ,  C07D237/26 ,  C07D237/28 ,  C07D237/32 ,  C07D239/74 ,  C07D401/04 ,  C07D401/06 ,  C07D403/02 ,  C07D413/02 ,  C07D413/04 ,  C07D413/14 ,  C07D417/02 ,  C07D417/04 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D491/02 ,  C07D498/02

Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

公开(公告)号：CA2632194C

公开(公告)日：2012-01-03

申请号：CA2632194

申请日：2006-11-15

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  MARMSATER FREDRIK P ,  ZHAO QIAN ,  GRESCHUK JULIE MARIE

IPC: C07D413/14 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: This invention provides compounds of Formula (I), wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

公开(公告)号：NZ587190A

公开(公告)日：2011-11-25

申请号：NZ58719006

申请日：2006-05-17

Applicant: ARRAY BIOPHARMA INC ,  ASTRAZENECA AB

Inventor： MARLOW ALLISON L ,  WALLACE ELI M ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON ,  BLAKE JIM ,  STOREY RICHARD ANTHONY ,  BOOTH REBECCA JANE ,  PITTMAN JOHN DAVID ,  LEONARD JOHN ,  FIELDING MARK RICHARD

IPC: A61K31/44 ,  A61K31/50 ,  C07D213/63 ,  C07D213/84 ,  C07D231/14 ,  C07D237/12

Abstract: Disclosed is a substituted 1,6-dihydropyridazine carboxamide compound of formula (I) where the substituents are as disclosed in the description. Also disclosed is the use of a compound of formula (I) in the manufacture of a medicament for treating hyperproliferative disorder or an inflammatory condition. Further disclosed is a method of producing a MEK inhibitory effect in a warm-blooded non-human animal in need of such treatment which comprises administering to said animal an effective amount of a compound of formula (I). Additional disclosed is a pharmaceutical composition comprising a compound of formula (I) with a pharmaceutically acceptable carrier. A method of preparing a compound of formula (I) is also disclosed.

公开(公告)号：PT1809280E

公开(公告)日：2011-11-15

申请号：PT05819172

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  WALLACE ELI M ,  ZHAO QIAN ,  HANS JEREMY ,  AICHER TOM ,  LAIRD ELLEN ,  ALLEN SHELLEY

IPC: A61K31/4245 ,  C07D413/00 ,  C07D417/00

公开(公告)号：BRPI0618668A2

公开(公告)日：2011-09-06

申请号：BRPI0618668

申请日：2006-11-15

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  MARMSATER FREDRIK P ,  ZHAO QIAN ,  GRESCHUK JULIE MARIE

IPC: C07D413/14 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: This invention provides compounds of Formula (I), wherein B, G, A, E, R 1 , R 2 , R 3 , m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

公开(公告)号：IS8961A

公开(公告)日：2011-06-16

申请号：IS8961

申请日：2011-06-16

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  HURLEY BRIAN T ,  MARLOW ALLISON L

IPC: A61K31/4184 ,  C07D235/08 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P1/00 ,  A61P1/18 ,  A61P3/10 ,  A61P9/08 ,  A61P9/10 ,  A61P13/08 ,  A61P13/12 ,  A61P17/00 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D235/04 ,  C07D235/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

公开(公告)号：DE602006021645D1

公开(公告)日：2011-06-09

申请号：DE602006021645

申请日：2006-11-15

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  GRESCHUK JULIE MARIE ,  ZHAO QIAN ,  MARMSAETER FREDRIK P ,  LUI WEIDONG ,  HENNINGS DAVID D

IPC: C07D413/14 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：PT2090575E

公开(公告)日：2011-06-06

申请号：PT09157031

申请日：2006-11-15

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  ZHAO QIAN ,  GRESCHUK JULIE MARIE ,  MARMSAETER FREDRIK P ,  LUI WEIDONG ,  HENNINGS DAVID D

IPC: C07D413/14 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：AU2006315383B2

公开(公告)日：2011-06-02

申请号：AU2006315383

申请日：2006-11-15

Applicant: ARRAY BIOPHARMA INC

Inventor： GRESCHUK JULIE MARIE ,  ZHAO QIAN ,  LIU WEIDONG ,  MARMSATER FREDRIK P ,  LYSSIKATOS JOSEPH P ,  HENNINGS D DAVID

IPC: C07D413/14 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: This invention provides compounds of Formula (I), wherein B, G, A, E, R 1 , R 2 , R 3 , m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

公开(公告)号：UA93678C2

公开(公告)日：2011-03-10

申请号：UAA200712647

申请日：2006-05-17

Applicant: ASTRAZENECA AB ,  ARRAY BIOPHARMA INC

Inventor： MARLOW ALLISON L ,  WALLACE ELI ,  SEO JEONGBEOB ,  LYSSIKATOS JOSEPH P ,  YANG HONG WOON ,  BLAKE JIM ,  STOREY RICHARD ANTHONY ,  BOOTH REBECCA JANE ,  PITTAM JOHN DAVID ,  LEONARD JOHN ,  FIELDING MARK RICHARD

IPC: C07D213/84 ,  A61K31/44 ,  C07D213/63

Abstract: РаскрытыМЕК-ингибиторы, полезныев лечениигиперпролиферативныхболезней, такихкакраки воспаление, умлекопитающихи воспалительныхсостояний. Такжераскрытыприменениетакихсоединенийв лечениигиперпролиферативныхболезнейу млекопитающихи фармацевтическиекомпозиции, которыесодержаттакиесоединения.