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    AMINO DERIVATIVES OF 2-METHYL-5-(2-HYDROXYSTYRYL)-1,3,4-THIADIAZOLE
    72.
    发明专利
    AMINO DERIVATIVES OF 2-METHYL-5-(2-HYDROXYSTYRYL)-1,3,4-THIADIAZOLE 未知

    公开(公告)号：CA1128050A

    公开(公告)日：1982-07-20

    申请号：CA325385

    申请日：1979-04-11

    Applicant: BASF AG

    Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

    IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12

    Abstract: ;; The present invention relates to novel alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thia-diazole corresponding to the general formula (I) (I) where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl or cycloalkenyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and their addition salts with physiologically acceptable acids. The invention is also directed to their process of preparation. These compounds thus obtained may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

    2-METHYL-5-(2-HYDROXYSTYRAL)-1,3,4-THIADIAZOLE
    73.
    发明专利
    2-METHYL-5-(2-HYDROXYSTYRAL)-1,3,4-THIADIAZOLE 未知

    公开(公告)号：CA1128049A

    公开(公告)日：1982-07-20

    申请号：CA325384

    申请日：1979-04-11

    Applicant: BASF AG

    Inventor： HAGEN HELMUT ,  THIEME PETER C ,  FRANKE ALBRECHT

    IPC: A61K31/425 ,  C07D285/12 ,  C07F9/6539

    Abstract: O.Z. 0050/033156 of the disclosure: 2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole of the formula (I) and processes for its preparation by condensing salicylaldehyde with 2,5-dimethyl-1,3,4-thiadiazole or 2-methyl-5-(tri-phenylphosphine-methylene)-1,3,4-thiadiazole. 2-Methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole is a valuable intermediate for the preparation of pharmacologically active compounds; for example the alkylamino-hydroxypropyl ethers can because of their .beta.-sympatholytic action, be used as drugs for the treatment of coronary diseases of the heart, cardiac arrhythmias and hypertonia.

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