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81.发明专利
公开(公告)号：SI2516433T1
公开(公告)日：2014-09-30
申请号：SI201030706
申请日：2010-12-20
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BRADLEY MICHAEL F , DELISLE ROBERT KIRK , HENNINGS D DAVID , KENNEDY APRIL L , MARMSATER FREDRIK P , MEDINA MATTHEW DAVID , MUNSON MARK C , RAST BRYSON , RIZZI JAMES P , RODRIGUEZ MARTHA E , TOPALOV GEORGE T , ZHAO QIAN
IPC: C07D471/00 , A61K31/00 , A61P9/00 , A61P19/00 , A61P29/00 , A61P35/00 , C07D519/00
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公开(公告)号：MX2013006763A
公开(公告)日：2014-01-08
申请号：MX2013006763
申请日：2011-12-13
Applicant: ARRAY BIOPHARMA INC
Inventor： MARESKA DAVID A , ZHAO QIAN , BOYS MARK LAURENCE , KENNEDY APRIL L , MUNSON MARK C , RAST BRYSON , RIZZI JAMES P , RODRIGUEZ MARTHA E , DELISLE ROBERT KIRK , HICKEN ERIK JAMES , MARMSATER FREDRIK P , NEWHOUSE BRAD , TOPALOV GEORGE T
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Se describen compuestos de la Fórmula I y sus sales farmacéuticamente aceptables, en donde R1, R2, R3, R4, R5 y R6 tienen los significados dados en la especificación, y son inhibidores de cFMS y son útiles en el tratamiento de fibrosis, enfermedades relacionadas con huesos, cáncer, trastornos autoinmunes, enfermedades inflamatorias, enfermedades cardiovasculares, dolor y quemaduras en un mamífero.
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公开(公告)号：CR20130349A
公开(公告)日：2013-08-09
申请号：CR20130349
申请日：2013-07-15
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , DELISLE ROBERT KIRK , HICKEN ERIK JAMES , KENNEDY APRIL L , MARESKA DAVID A , MARMSATER FREDRIK P , MUNSON MARK C , NEWHOUSE BRAD , RAST BRYSON , RIZZI JAMES P , RODRIGUEZ MARTHA E , TOPALOV GEORGE T , ZHAO QIAN
IPC: C07D471/04
Abstract: COMPUESTOS DE FÓRMULA I.-
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84.发明专利
公开(公告)号：ZA201205505B
公开(公告)日：2013-04-24
申请号：ZA201205505
申请日：2012-07-20
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , DELISLE ROBERT KIRK , KENNEDY APRIL L , MEDINA MATTHEW DAVID , RAST BRYSON , RODRIGUEZ MARTHA E , ZHAO QIAN , BRADLEY MICHAEL F , HENNINGS D DAVID , MARMSATER FREDERIK P , MUNSON MARK C , RIZZI JAMES P , TOPALOV GEORGE T
IPC: A61P20060101 , A61K20060101 , C07D20060101
Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.
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公开(公告)号：MX2012007329A
公开(公告)日：2012-10-15
申请号：MX2012007329
申请日：2010-12-20
Applicant: ARRAY BIOPHARMA INC
Inventor： ZHAO QIAN , MARMSATER FREDRIK P , BOYS MARK LAURENCE , DELISLE ROBERT KIRK , BRADLEY MICHAEL , HENNINGS D DAVID , KENNEDY APRIL L , MEDINA MATTHEW , MUNSON MARK C , RAST BRYSON , RIZZI JAMES P , RODRIGUEZ MARTHA E
IPC: A61K31/437 , C07D471/04 , A61K31/4985 , A61P9/00 , A61P19/08 , A61P29/00 , A61P35/00 , C07D519/00
Abstract: Se describen compuestos de la Fórmula (I); y sales farmacéuticamente aceptables de los mismos, en donde R1, R2, R3, R4 y R5 tienen los significados dados en la especificación, los cuales son inhibidores de cFMS y son útiles en el tratamiento de trastornos relacionados con los huesos, cáncer, trastornos autoinmunes, enfermedades inflamatorias, enfermedades cardiovasculares y dolor.
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Patent Agency Ranking
公开(公告)号：NO328913B1
公开(公告)日：2010-06-14
申请号：NO20054453
申请日：2005-09-26
Applicant: ARRAY BIOPHARMA INC
Inventor： RODRIGUEZ MARTHA E , GRONEBERG ROBERT D , MUNSON MARK , MARESKA DAVID , KIM YOUNGBOO , RIZZI JAMES , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: C07D401/14 , A61K20060101 , A61K31/416 , A61K31/4162 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D231/56 , C07D261/20 , C07D403/04 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02
Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号：DE60135752D1
公开(公告)日：2008-10-23
申请号：DE60135752
申请日：2001-07-05
Applicant: ARRAY BIOPHARMA INC , AMGEN INC
Inventor： BURGESS LAURENCE E , GAUDINO JOHN , GRONEBERG ROBERT D , NORMAN MARK H , RODRIGUEZ MARTHA E , SUN XICHENG , WALLACE ELI M
IPC: C07C311/19 , A61K31/165 , A61K31/166 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/341 , A61K31/4045 , A61K31/41 , A61K31/4402 , A61P3/10 , A61P7/12 , A61P35/00 , A61P43/00 , C07C237/22 , C07C311/13 , C07C311/29 , C07D209/14 , C07D209/16 , C07D213/40 , C07D257/04 , C07D307/52
Abstract: Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein A, B; R1, R2, R3, R4 and R5 are as defined in the specification.Such compounds are tyrosine phosphatase inhibitors and useful in the treatment or prevention of Type II Diabetes Mellitus. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds, a method for treating or preventing Type II Diabetes Mellitus.
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公开(公告)号：AU2001278188B2
公开(公告)日：2007-05-17
申请号：AU2001278188
申请日：2001-07-05
Applicant: AMGEN INC , ARRAY BIOPHARMA INC
Inventor： GAUDINO JOHN , RODRIGUEZ MARTHA E , WALLACE ELI M , GRONEBERG ROBERT D , BURGESS LAURENCE E , SUN XICHENG , NORMAN MARK H
IPC: C07C311/19 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/341 , A61K31/4045 , A61K31/41 , A61K31/4402 , A61P3/10 , A61P7/12 , A61P35/00 , A61P43/00 , C07C237/22 , C07C311/13 , C07C311/29 , C07D209/14 , C07D209/16 , C07D213/40 , C07D257/04 , C07D307/52
Abstract: Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein A, B; R1, R2, R3, R4 and R5 are as defined in the specification.Such compounds are tyrosine phosphatase inhibitors and useful in the treatment or prevention of Type II Diabetes Mellitus. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds, a method for treating or preventing Type II Diabetes Mellitus.
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公开(公告)号：NO20054453D0
公开(公告)日：2005-09-26
申请号：NO20054453
申请日：2005-09-26
Applicant: ARRAY BIOPHARMA INC
Inventor： RODRIGUEZ MARTHA E , GRONEBERG ROBERT D , MUNSON MARK , MARESKA DAVID , KIM YOUNGBOO , RIZZI JAMES , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC: A61K20060101 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D231/56 , C07D261/20 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D
Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号：MA55511A
公开(公告)日：2022-02-09
申请号：MA55511
申请日：2020-03-30
Applicant: ARRAY BIOPHARMA INC
Inventor： BLAKE JAMES F , BOYS MARK LAURENCE , CHICARELLI MARK JOSEPH , COOK ADAM W , ELSAYED MOHAMED S A , FELL JAY BRADFORD , FISCHER JOHN P , HINKLIN RONALD JAY , JIANG YUTONG , MCNULTY OREN T , MEJIA MACEDONIO J , RODRIGUEZ MARTHA E , WONG CHRISTINA E
IPC: A61K31/53 , A61P35/00 , C07D401/14 , C07D403/04 , C07D451/04 , C07D471/10 , C07D491/107 , C07D513/10 , C07D519/00
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