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公开(公告)号:DK1984515T3
公开(公告)日:2010-12-06
申请号:DK07726268
申请日:2007-01-31
Applicant: BASF SE
Inventor: HAUER BERNHARD , STUERMER RAINER , NESTL BETTINA M , KROUTIL WOLFGANG , FABER KURT
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公开(公告)号:CA2735769A1
公开(公告)日:2010-03-25
申请号:CA2735769
申请日:2009-09-15
Applicant: BASF SE
Inventor: BREUER MICHAEL , PLETSCH ANDREAS , HAUER BERNHARD , SIEGEL WOLFGANG
Abstract: The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
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公开(公告)号:DE502006006005D1
公开(公告)日:2010-03-11
申请号:DE502006006005
申请日:2006-11-24
Applicant: BASF SE
Inventor: HAERING DIETMAR , HERRERA TABOADA LIDCAY , HAUER BERNHARD , FRIEDRICH THOMAS , GOETHLICH ALEXANDER
IPC: C08F220/18 , C08F8/14 , C08F220/62
Abstract: Provided is a process for esterifying or transesterifying side chains in polymers, which involves esterifying or transesterifying the carboxyl group having the R4 radical of a copolymer obtained by polymerizing a (meth)acrylate of formula (I), and a monomer of formula (II): wherein R1 and R3 are independently H or CH3, R2 and R4 are independently H or an alkyl radical which is optionally substituted by functional groups such as acryloyl, ether, amino, epoxy, halogen or sulfonic acid groups, and n is from 1 to 40, with an alcohol in the presence of an enzyme which catalyzes the esterifying or transesterifying. Further provided is the esterified or transesterified polymer product and its use.
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公开(公告)号:AT455807T
公开(公告)日:2010-02-15
申请号:AT06819748
申请日:2006-11-24
Applicant: BASF SE
Inventor: HAERING DIETMAR , HERRERA TABOADA LIDCAY , HAUER BERNHARD , FRIEDRICH THOMAS , GOETHLICH ALEXANDER
IPC: C08F220/18 , C08F8/14 , C08F220/62
Abstract: Provided is a process for esterifying or transesterifying side chains in polymers, which involves esterifying or transesterifying the carboxyl group having the R4 radical of a copolymer obtained by polymerizing a (meth)acrylate of formula (I), and a monomer of formula (II): wherein R1 and R3 are independently H or CH3, R2 and R4 are independently H or an alkyl radical which is optionally substituted by functional groups such as acryloyl, ether, amino, epoxy, halogen or sulfonic acid groups, and n is from 1 to 40, with an alcohol in the presence of an enzyme which catalyzes the esterifying or transesterifying. Further provided is the esterified or transesterified polymer product and its use.
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公开(公告)号:AT452149T
公开(公告)日:2010-01-15
申请号:AT06708599
申请日:2006-03-02
Applicant: BASF SE
Inventor: HAERING DIETMAR , HAUER BERNHARD , PFEIFFER THOMAS , FECHTENKOETTER ANDREAS , LARBIG HARALD , BECK ERICH
IPC: C08F8/14 , C08F210/02 , C08F255/02 , C09D11/02 , C09D133/08 , C09K23/52 , C14C9/00 , D06M15/21
Abstract: Polyolefin waxes bearing (meth)acrylate groups, process for preparing them and their use.
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公开(公告)号:ES2328264T3
公开(公告)日:2009-11-11
申请号:ES05745555
申请日:2005-05-04
Applicant: BASF SE
Inventor: STURMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL , SCHRODER HARTWIG
IPC: C12P7/02 , C07D333/16 , C12N9/04 , C12P20060101 , C12P13/00 , C12P17/00
Abstract: Método para la producción de alcanoles ópticamente activos de la fórmula I ** ver fórmula** donde n representa un valor numérico entero de 0 a 5; Cyc representa un anillo carbocíclico o heterocíclico, dado el caso sustituido, mono o polinuclear, saturado o insaturado, y R 1 representa halógeno, SH, OH, NO2, NR 2 R 3 o NR 2 R 3 R 4+ X - , donde R 2 , R 3 y R 4 independientemente uno de otro representan H o un radical alquilo pequeño o alcoxi pequeño con 1 a 6 átomos de carbono y X - representa un ión contrario, donde en un medio que contiene una alcanona de la fórmula II, ** ver fórmula** donde n, Cyc y R 1 en los significados arriba indicados, se incuba una enzima (E), con una secuencia de polipéptidos (i) SEQ ID NO: 2 o (ii) en la que hasta 25% de los radicales aminoácido, respecto a SEQ ID NO:2, ha sido cambiado mediante borrado, inserción, sustitución, o una combinación de ellos, y la cual aun posee una actividad enzimática de por lo menos 50% de la de SEQ ID NO:2 en presencia de equivalentes de reducción, donde el compuesto de la fórmula II es reducido por vía enzimática hasta el compuesto de la fórmula I, y los equivalentes de reducción consumidos en el curso de la reacción son generados nuevamente por transformación de un alcohol de sacrificio hasta la correspondiente cetona de sacrificio con la ayuda de la enzima (E) y la cetona de sacrificio es eliminada al menos parcialmente del medio de reacción, y se aísla el producto formado (I).
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公开(公告)号:AT438730T
公开(公告)日:2009-08-15
申请号:AT06754774
申请日:2006-04-20
Applicant: BASF SE
Inventor: HAERING DIETMAR , HAUER BERNHARD , BECKER STEFAN
IPC: C12P13/02
Abstract: Processes for enzymatic synthesis comprising: (a) providing an aliphatic poly(oxyalkylene)amine; and (b) reacting the aliphatic poly(oxyalkylene)amine with a reactant selected from the group consisting of acrylic acid compounds and alkyl esters thereof, in the presence of a hydrolase in bulk or in a liquid reaction medium comprising an organic solvent to for a poly(oxyalkylene)acrylamide.
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公开(公告)号:DE502005007057D1
公开(公告)日:2009-05-20
申请号:DE502005007057
申请日:2005-11-15
Applicant: BASF SE
Inventor: STUERMER RAINER , HAUER BERNHARD , DREW DEJANA , BREUER MICHAEL , SCHROEDER HARTWIG
Abstract: The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.
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公开(公告)号:DE502006002664D1
公开(公告)日:2009-03-05
申请号:DE502006002664
申请日:2006-06-13
Applicant: BASF SE
Inventor: BESELIN ANKE , ROSENAU FRANK , JAEGER KARL-ERICH , BREUER MICHAEL , HAUER BERNHARD
IPC: C12N9/52
Abstract: The invention relates to novel proteins, especially with protease activity, which promote the production of extracellular lipases by bacteria, especially of the genus Burkholderia, nucleic acid sequences encoding them, expression constructs containing them, hosts transformed with them, methods for the production of the proteins with protease activity and methods for the production of lipases, especially by bacteria of the genus Burkholderia.
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公开(公告)号:AT414156T
公开(公告)日:2008-11-15
申请号:AT02782936
申请日:2002-10-17
Applicant: BASF SE
Inventor: MATUSCHEK MARKUS , STUERMER RAINER , HAUER BERNHARD , KLEBE GERHARD , BOCOLA MARCO
Abstract: The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286, 289 in the prototype lipase sequence SEQ ID NO: 1.
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