Polymer coatings containing drug powder of controlled morphology

    公开(公告)号:AU2015203152B2

    公开(公告)日:2017-01-05

    申请号:AU2015203152

    申请日:2015-06-12

    Abstract: H: \xd\Interwoven\NRPortbl\DCC\SXD\7897863_1.doc-6/10/2015 A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate; wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent. CO, =3) LU i C/)3 hI xL 0'01 W uiI

    Drug delivery medical device
    82.
    发明专利

    公开(公告)号:AU2013331003B2

    公开(公告)日:2016-11-24

    申请号:AU2013331003

    申请日:2013-10-18

    Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. The coating includes particles of a pharmaceutical agent. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer material. A method of releasing a pharmaceutical agent at a target site is also disclosed. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer material; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

    Stents having biodegradable layers
    83.
    发明专利

    公开(公告)号:AU2015200571B2

    公开(公告)日:2016-11-17

    申请号:AU2015200571

    申请日:2015-02-06

    Abstract: Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

    Bioabsorbable biomedical implants
    85.
    发明专利

    公开(公告)号:AU2014248508A1

    公开(公告)日:2015-11-05

    申请号:AU2014248508

    申请日:2014-03-12

    Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average strut thickness of no more than about 120 μι&eegr;. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

    HOLDER FOR ELECTRICALLY CHARGING A SUBSTRATE DURING COATING

    公开(公告)号:CA2667228C

    公开(公告)日:2015-07-14

    申请号:CA2667228

    申请日:2007-10-23

    Abstract: A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.

    Polymer coatings containing drug powder of controlled morphology

    公开(公告)号:AU2015203152A1

    公开(公告)日:2015-07-09

    申请号:AU2015203152

    申请日:2015-06-12

    Abstract: H: \xd\Interwoven\NRPortbl\DCC\SXD\7897863_1.doc-6/10/2015 A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate; wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent. CO, =3) LU i C/)3 hI xL 0'01 W uiI

    Drug delivery medical device
    88.
    发明专利

    公开(公告)号:AU2013331003A1

    公开(公告)日:2015-05-07

    申请号:AU2013331003

    申请日:2013-10-18

    Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. The coating includes particles of a pharmaceutical agent. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer material. A method of releasing a pharmaceutical agent at a target site is also disclosed. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer material; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

    Stents having biodegradable layers
    89.
    发明专利

    公开(公告)号:AU2015200571A1

    公开(公告)日:2015-04-09

    申请号:AU2015200571

    申请日:2015-02-06

    Abstract: Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

    POLYMER COATINGS CONTAINING DRUG POWDER OF CONTROLLED MORPHOLOGY

    公开(公告)号:CA2615452C

    公开(公告)日:2015-03-31

    申请号:CA2615452

    申请日:2006-07-14

    Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

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