公开(公告)号：CA2005741A1

公开(公告)日：1990-06-26

申请号：CA2005741

申请日：1989-12-15

Applicant: HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

Inventor： HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

IPC: C07C311/16 ,  C07D217/02 ,  C07D217/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10 ,  C07D401/00 ,  C07D413/00

Abstract: Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

公开(公告)号：CA2551602A1

公开(公告)日：2005-07-14

申请号：CA2551602

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HOSOYA TAKAMITSU ,  FUKUHARA TAKESHI ,  SUZUKI MASAAKI ,  HAGIWARA MASATOSHI

IPC: A61K45/00 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  A61P31/12 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D295/06 ,  C07D295/12 ,  C07D401/12 ,  C12N15/113 ,  C12Q1/48 ,  H04M1/21

Abstract: It is intended to provide: (1) antiviral agents lowering or inhibiting the activity of an SR protein, more specifically speaking, (i) an antiviral agen t promoting the dephosphorylation of an SR protein and (ii) an antiviral agent inhibiting a protein phosphorylating an SR protein; (2) an antiviral agent inhibiting the expression of an SR protein; and (3) an antiviral agent activating a protein having an opposite function to an SR protein. It is als o intended to provide compounds which inhibit SRPK phosphorylating an SR protein. These compounds inhibit the activity of the SR protein and show an antiviral effect. Thus, antiviral agents which are efficacious against a nov el virus and widely applicable and show a highly sustained effect are provided to cope with the occurrence of various novel viruses.

公开(公告)号：DK2666481T3

公开(公告)日：2019-02-25

申请号：DK13001724

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HAGIWARA MASATOSHI ,  FUKUHARA TAKESHI ,  SUZUKI MASAAKI ,  HOSOYA TAKAMITSU

IPC: A61K45/00 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D213/81 ,  C07D295/06 ,  C07D295/12 ,  C12N15/113 ,  H04M1/21

公开(公告)号：CA2801848C

公开(公告)日：2015-03-31

申请号：CA2801848

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HAGIWARA MASATOSHI ,  FUKUHARA TAKESHI ,  SUZUKI MASAAKI ,  HOSOYA TAKAMITSU

IPC: C07D401/12 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D213/81 ,  C12N9/12 ,  C12N15/113 ,  H04M1/21

Abstract: The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad- spectrum antiviral agents applicable to new viruses.

公开(公告)号：AU2004308825B2

公开(公告)日：2011-03-10

申请号：AU2004308825

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HOSOYA TAKAMITSU ,  SUZUKI MASAAKI ,  FUKUHARA TAKESHI ,  HAGIWARA MASATOSHI

IPC: C07D213/81 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C12N15/113 ,  H04M1/21

Abstract: The present invention is related to an aniline derivative represented by the following formula (I): wherein, R 1 , R 2 , R 3 , R 4 , Q and W are defined elsewhere. A typical compound of the aniline derivatives of invention is depicted in the figure. The aniline derivatives of invention have antiviral activity

公开(公告)号：ES2711313T3

公开(公告)日：2019-05-03

申请号：ES13001724

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HAGIWARA MASATOSHI ,  FUKUHARA TAKESHI ,  SUZUKI MASAAKI ,  HOSOYA TAKAMITSU

IPC: A61K45/00 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D213/81 ,  C07D295/06 ,  C07D295/12 ,  C12N15/113 ,  H04M1/21

Abstract: Un compuesto representado por la siguiente fórmula (I):**Fórmula** en donde R1 es un átomo de hidrógeno, un grupo alquilo C1-6 que puede tener sustituyentes, o un átomo de halógeno; R2 es un átomo de hidrógeno; R3 es un grupo 4-piridilo; R4 es un átomo de hidrógeno; Q es -C(O)-, -C(S)-, -SO2-, -C(S)NHC(O)-, -C(O)NHC(O)- o -C(O)NHC(S)-; y W es un grupo representado por la siguiente fórmula (II):**Fórmula** en donde R5 y R6, junto con el átomo de nitrógeno adyacente, forman un heterociclo que puede tener un sustituyente.

公开(公告)号：CA2551602C

公开(公告)日：2013-03-26

申请号：CA2551602

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HAGIWARA MASATOSHI ,  FUKUHARA TAKESHI ,  SUZUKI MASAAKI ,  HOSOYA TAKAMITSU

IPC: A61K31/4545 ,  H04M1/02 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/455 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/55 ,  A61P31/12 ,  A61P31/14 ,  C07D213/81 ,  C12N9/12 ,  C12N9/16 ,  C12N15/113 ,  C12Q1/48 ,  H04M1/21

Abstract: The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.

公开(公告)号：CA2801848A1

公开(公告)日：2005-07-14

申请号：CA2801848

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HAGIWARA MASATOSHI ,  FUKUHARA TAKESHI ,  SUZUKI MASAAKI ,  HOSOYA TAKAMITSU

IPC: C07D401/12 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D213/81 ,  C12N9/12 ,  C12N15/113 ,  H04M1/21

Abstract: The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.

公开(公告)号：AU2004308825A1

公开(公告)日：2005-07-14

申请号：AU2004308825

申请日：2004-12-24

Applicant: HAGIWARA MASATOSHI

Inventor： HOSOYA TAKAMITSU ,  SUZUKI MASAAKI ,  FUKUHARA TAKESHI ,  HAGIWARA MASATOSHI

IPC: A61K31/4453 ,  H04M1/02 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D213/81 ,  C12N15/113 ,  H04M1/21

Abstract: The present invention is related to an aniline derivative represented by the following formula (I): wherein, R 1 , R 2 , R 3 , R 4 , Q and W are defined elsewhere. A typical compound of the aniline derivatives of invention is depicted in the figure. The aniline derivatives of invention have antiviral activity

公开(公告)号：EP1712242B1

公开(公告)日：2018-05-30

申请号：EP04807749.9

申请日：2004-12-24

Applicant: Hagiwara, Masatoshi

Inventor： HAGIWARA, Masatoshi ,  FUKUHARA, Takeshi ,  SUZUKI, Masaaki ,  HOSOYA, Takamitsu

IPC: A61K45/00 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/55 ,  C07D295/12 ,  C07D295/06 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D401/12 ,  A61P31/12 ,  C12Q1/48

CPC classification number: A61K31/444 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D211/14 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C12N15/1137 ,  Y02A50/385 ,  Y02A50/389 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467

Abstract: The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.