公开(公告)号：CA2005741A1

公开(公告)日：1990-06-26

申请号：CA2005741

申请日：1989-12-15

Applicant: HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

Inventor： HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

IPC: C07C311/16 ,  C07D217/02 ,  C07D217/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10 ,  C07D401/00 ,  C07D413/00

Abstract: Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

公开(公告)号：CA2013432A1

公开(公告)日：1990-10-10

申请号：CA2013432

申请日：1990-03-29

Applicant: KIMURA MASAYASU ,  NAITO KENJI ,  SAKUMA OSAMU ,  MORITA TADASHI

Inventor： KIMURA MASAYASU ,  NAITO KENJI ,  SAKUMA OSAMU ,  MORITA TADASHI

IPC: A61K31/14 ,  A61K31/215 ,  A61P21/02 ,  C07C43/174 ,  C07C45/41 ,  C07C57/34 ,  C07C57/40 ,  C07C69/612 ,  C07C69/618 ,  C07C205/11 ,  C07C209/12 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C211/30 ,  C07C211/49 ,  C07C211/63 ,  C07C215/18 ,  C07C215/30 ,  C07C215/40 ,  C07C217/10 ,  C07C217/20 ,  C07C219/22 ,  C07C225/06 ,  C07C225/16 ,  C07C227/18 ,  C07C229/34 ,  C07C229/38 ,  C07C231/12 ,  C07C233/43 ,  C07C317/28 ,  C07C323/25 ,  C07C323/62 ,  C07D213/06 ,  C07D213/16 ,  C07D295/02 ,  C07D295/135 ,  C07D309/12 ,  C07D339/08 ,  A61K31/245 ,  C07C323/32 ,  C07C217/48 ,  C07C323/63

Abstract: A guaternary ammonium compound having a muscle relaxation activity represented by the formula (I): wherein R1 represents a methylene, a lower alkylenoxy, a lower alkenylene, a lower alkynylene, -CO-, -COO-, a lower alkylene carbonyloxy, -CH(OR5)-, a lower alkylenecarbonyl, a hydroxy lower alkylene, -O-, -S-, -SO-, or -SO2-; R2 represents a hydrogen atom, a hydroxy lower alkyl, an aldehyde, a lower alkyl carbonyl, -NO2 , or -NHR6; R3 represents a hydrogen atom of a group -R1,(CH2)a-¢CH(CH2A)-CH2!b-A; R4 represents an anion; R5 and R6 represent a hydrogen atom or a acetyl; A represents a quaternary ammonium group; a represents an integer of 1 to 8; b represents 0 or 1; m represents an integer of 1 to 4; and (Z) represents a trivalent benzene ring, a trivalent naphthalene ring, a trivalent diphenyl or a trivalent ethane radical.

公开(公告)号：WO1995034542A1

公开(公告)日：1995-12-21

申请号：PCT/JP1995001166

申请日：1995-06-09

Applicant: TOKYO TANABE COMPANY LIMITED ,  TOMARI, Masazumi ,  SAKUMA, Osamu ,  OHTO, Hiroyuki ,  NAGAOKA, Kazuhiko ,  TSUJI, Michinori

Inventor： TOKYO TANABE COMPANY LIMITED

IPC: C07D249/08

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: A triazole compound represented by general formula (I) or a physiologically acceptable salt or hydrate thereof, and an antifungal agent containing the same as the active ingredient, wherein R represents hydrogen or methyl; R represents methyl, 4-methyl-4H-1,2,4-triazol-3-yl or (4-methyl-4H-1,2,4-triazol-3-yl)methyl; R represents hydrogen or methyl; and m and n represent each 0 to 2. These compounds have a remarkably potent antifungal effect and an excellent safety, and are efficacious in treating human or animal superficial or deep-seated mycosis.

Abstract translation: 由通式（I）表示的三唑化合物或其生理上可接受的盐或水合物，以及含有与活性成分相同的抗真菌剂，其中R 1表示氢或甲基; R 2表示甲基，4-甲基-4H-1,2,4-三唑-3-基或（4-甲基-4H-1,2,4-三唑-3-基）甲基; R 3表示氢或甲基; m和n分别表示0〜2.这些化合物具有非常有效的抗真菌作用和优异的安全性，并且对于治疗人或动物表面或深层的真菌病有效。

公开(公告)号：WO1995026343A1

公开(公告)日：1995-10-05

申请号：PCT/JP1995000597

申请日：1995-03-29

Applicant: TOKYO TANABE COMPANY LIMITED ,  TOMARI, Masazumi ,  SAKUMA, Osamu ,  OHTO, Hiroyuki ,  NAGAOKA, Kazuhiko ,  TSUJI, Michinori ,  OSAKA, Yoko ,  TAKAGI, Atsushi

Inventor： TOKYO TANABE COMPANY LIMITED

IPC: C07D249/08

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: An antimycotic triazole derivative represented by general formula (I), a physiologically acceptable salt thereof, and an antimycotic agent containing the same as the active ingredient: wherein R and R represent each independently hydrogen, lower alkyl or cycloalkyl, or R and R are combined together to represent alkylene; R represents lower alkyl, cycloalkyl, alkyl having a double bond(s), optionally substituted heterocycle or -NR R ; R represents hydrogen or lower alkyl and R represents optionally substituted heterocycle, or R and R are combined together to represent sulfur-containing alkylene; R represents hydrogen or lower alkyl; X represents hydrogen, halogen or trifluoromethyl; X represents hydrogen or halogen; and n represents 0 to 2. These substances have a remarkably potent antimycotic activity and are useful for curing animal and human superficial and deep-seated mycoses.

Abstract translation: 由通式（I）表示的抗真菌性三唑衍生物，其生理学上可接受的盐和含有该活性成分的抗真菌剂：其中R 1和R 2各自独立地表示氢，低级烷基或环烷基， 或R 1和R 2结合在一起代表亚烷基; R 3表示低级烷基，环烷基，具有双键的烷基，任选取代的杂环或-NR 5 R 6; R 5表示氢或低级烷基，R 6表示任选取代的杂环，或R 5和R 6结合在一起代表含硫亚烷基; R 4代表氢或低级烷基; X 1表示氢，卤素或三氟甲基; X 2表示氢或卤素; 并且n表示0至2.这些物质具有非常有效的抗真菌活性，并且可用于治疗动物和人类表浅和深层真菌病。

公开(公告)号：JPH117222A

公开(公告)日：1999-01-12

申请号：JP19471497

申请日：1997-06-16

Applicant: SAKUMA OSAMU

Inventor： SAKUMA OSAMU

IPC: G03G21/00

Abstract: PROBLEM TO BE SOLVED: To confirm a copied result in advance which was unable to predicted by a conventional copying machine through an external monitor by utilizing a CCD. SOLUTION: An original is irradiated with light and the image thereof is transmitted to the CCD through a lens. The image of an electric signal converted by the CCD is received by the monitor installed outside the copying machine. Thus, the position of the original can be adjusted and magnification can be changed. Besides, a copying paper and toner are prevented from being wastefully consumed.

公开(公告)号：JPH10333809A

公开(公告)日：1998-12-18

申请号：JP13827797

申请日：1997-05-28

Applicant: SAKUMA OSAMU

Inventor： SAKUMA OSAMU

IPC: G09B21/00 ,  G06F3/02 ,  G06F3/16 ,  G10L13/04 ,  H04M11/00 ,  G10L5/02

Abstract: PROBLEM TO BE SOLVED: To provide a character inputting and voice converting device that can perform voice conversation with a communicating party only by a key operation without the generation of any noise sound in the surroundings, and a portable telephone equipped with the device. SOLUTION: This converting device is provided with less than 20 keys for transmitting vowels (A, I, U, E, O), the basic articulation of KA-line, SA-line, TA-line, NA-line, HA-line, MA-line, YA-line, RA-line, WA-line, BA-line, DA-line, GA-line, PA-line, and ZA-lione, and the composite basic articulation of KYA-line, GYA-line, BYA-line, PYA-line, NYA-line, HYA-line, MYA-line, RYA-line, JYA- line, CHA-line, and SYA-line by the inputting operation of alphanumeric character keys from one time to three times. Moreover, this device is provided with a voice converting means for transmitting a long vowel and a consonant by the key operation.