公开(公告)号：CA2005741A1

公开(公告)日：1990-06-26

申请号：CA2005741

申请日：1989-12-15

Applicant: HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

Inventor： HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

IPC: C07C311/16 ,  C07D217/02 ,  C07D217/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10 ,  C07D401/00 ,  C07D413/00

Abstract: Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

公开(公告)号：WO1989008094A1

公开(公告)日：1989-09-08

申请号：PCT/JP1989000201

申请日：1989-02-28

Applicant: TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA ,  ENDO, Akira ,  TOSHIOKA, Tadashi ,  UMEZAWA, Isao ,  YUASA, Masayuki ,  INABA, Takashi ,  INOUE, Tsutomu

Inventor： TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA

IPC: C07C69/28

CPC classification number: C07C69/00 ,  C07C2603/00 ,  C07D309/30

Abstract: Compounds represented by general formula (I) (wherein R1 and R2 may be the same or different and each represents a hydrogen or halogen atom), their open-ring free acid derivatives, amides and salts are disclosed. A process for preparing the above-described compounds from known compound ML-236B is also disclosed.