公开(公告)号：WO1998035968A1

公开(公告)日：1998-08-20

申请号：PCT/JP1997004878

申请日：1997-12-26

Applicant: POLA CHEMICAL INDUSTRIES, INC. ,  NAMIKI, Takayuki ,  YUASA, Masayuki ,  TAKAKUWA, Takako ,  ICHINOMIYA, Satoshi ,  TAMAI, Masashi ,  HIYAMA, Naoki ,  KAWAZU, Yukio ,  YAHIRO, Tomoaki ,  SUGIO, Mayumi

Inventor： POLA CHEMICAL INDUSTRIES, INC.

IPC: C07D487/14

CPC classification number: C07D487/14 ,  A61K31/519

Abstract: Remedies/preventives for respiratory diseases containing as the active ingredient compounds represented by general formula (1) or salts thereof: (1)(wherein R represents linear, branched or cyclic C1-10 alkyl; and R represents hydrogen, halogeno, substituted alkyl, optionally substituted amino, carboxy, alkoxycarbonyl, carbamoyl or alkylcarbamoyl). These compounds have excellent bronchodilating and respiratory tract contraction-inhibitory effects.

Abstract translation: 含有作为由通式（1）表示的活性成分化合物或其盐的呼吸系统疾病的治疗/预防措施：（1）（其中R 1表示直链，支链或环状的C 1-10烷基; R 2表示氢 ，卤代，取代的烷基，任选取代的氨基，羧基，烷氧基羰基，氨基甲酰基或烷基氨基甲酰基）。 这些化合物具有优异的支气管扩张和呼吸道收缩抑制作用。

公开(公告)号：WO1989008094A1

公开(公告)日：1989-09-08

申请号：PCT/JP1989000201

申请日：1989-02-28

Applicant: TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA ,  ENDO, Akira ,  TOSHIOKA, Tadashi ,  UMEZAWA, Isao ,  YUASA, Masayuki ,  INABA, Takashi ,  INOUE, Tsutomu

Inventor： TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA

IPC: C07C69/28

CPC classification number: C07C69/00 ,  C07C2603/00 ,  C07D309/30

Abstract: Compounds represented by general formula (I) (wherein R1 and R2 may be the same or different and each represents a hydrogen or halogen atom), their open-ring free acid derivatives, amides and salts are disclosed. A process for preparing the above-described compounds from known compound ML-236B is also disclosed.

公开(公告)号：CA2005741A1

公开(公告)日：1990-06-26

申请号：CA2005741

申请日：1989-12-15

Applicant: HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

Inventor： HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  HAGIWARA MASATOSHI ,  INOUE TSUTOMU ,  NAITOH KENJI ,  SAKUMA OSAMU ,  YUASA MASAYUKI ,  MORITA TADASHI ,  TOSHIOKA TADASHI ,  UMEZAWA ISAO ,  INABA TAKASHI

IPC: C07C311/16 ,  C07D217/02 ,  C07D217/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10 ,  C07D401/00 ,  C07D413/00

Abstract: Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.