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    PROCESS FOR PRODUCING AMIDE DERIVATIVES AND INTERMEDIATES
    4.
    发明申请
    PROCESS FOR PRODUCING AMIDE DERIVATIVES AND INTERMEDIATES 审中-公开
    生产酰胺衍生物和中间体的方法

    公开(公告)号：WO1997011937A1

    公开(公告)日：1997-04-03

    申请号：PCT/JP1996002756

    申请日：1996-09-24

    Applicant: JAPAN TOBACCO INC. ,  AGOURON PHARMACEUTICALS, INC. ,  INABA, Takashi ,  YAMADA, Yasuki

    Inventor： JAPAN TOBACCO INC. ,  AGOURON PHARMACEUTICALS, INC.

    IPC: C07C323/25

    CPC classification number: C07D413/04 ,  C07C319/14 ,  C07D217/26 ,  C07D263/14 ,  C07D321/06 ,  C07C323/25 ,  C07C323/42

    Abstract: A process for producing amide derivatives represented by general formula [XV] or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds [XV], i.e., those involving the compounds [XVI] having an HIV protease inhibitory effect in high yields. The n ovel intermediates are highly advantageous as intermediates for producing not only the above compounds [XVI] but also those which are useful as an X-ray contrast medium, etc.

    Abstract translation: 制备由通式[XV]表示的酰胺衍生物或其对映异构体的方法，用于制备这些化合物的新型中间体化合物等及其制备方法，其中每个符号如说明书中所定义。 与常规方法相比，上述方法可以非常容易地实现，并能高效率地生产具有高蛋白酶抑制作用的化合物[ⅩⅥ]的化合物[ⅩⅤ]。 这些中间体作为不仅产生上述化合物[XVI]的中间体是非常有利的，而且也用作用作X射线造影剂等的那些。

    PROCESS FOR PRODUCING CLEAN ARTICLE
    5.
    发明申请
    PROCESS FOR PRODUCING CLEAN ARTICLE 审中-公开
    生产清洁用品的工艺

    公开(公告)号：WO1994020601A1

    公开(公告)日：1994-09-15

    申请号：PCT/JP1994000381

    申请日：1994-03-09

    Applicant: DAIKIN INDUSTRIES LTD. ,  IDE, Satoshi ,  INABA, Takashi ,  MATSUDA, Takahiro ,  AOYAMA, Hirokazu

    Inventor： DAIKIN INDUSTRIES LTD.

    IPC: C11D17/00

    CPC classification number: C23G5/02 ,  C11D7/5018 ,  H05K3/26

    Abstract: A process for producing clean articles comprising the steps of contacting an article bearing contaminants adherent thereto with an organic solvent except for fluorohydrocarbon and rinsing the article thus treated by contact with an aliphatic fluorinated hydrocarbon represented by the general formula: CnFmH2n+2-m. This process enables the use of organic solvents that have been difficult to use, can dispense with the use of purified water, serves to reduce the cost necessary in the drying step and waste water disposal facilities, and prevents environmental pollution.

    Abstract translation: 一种生产清洁物品的方法，包括以下步骤：将含有污染物的物品与除氟氟烃之外的有机溶剂接触，并通过与由通式C n F m H 2n + 2-m表示的脂族氟代烃接触进行处理。 该方法能够使用难以使用的有机溶剂，可以省去使用净化水，用于降低干燥步骤和废水处理设备所需的成本，并防止环境污染。

    DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND INTERMEDIATES THEREOF, MEDICINAL USE OF THE SAME, AND PROCESSES FOR PRODUCING THE SAME
    10.
    发明申请
    DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND INTERMEDIATES THEREOF, MEDICINAL USE OF THE SAME, AND PROCESSES FOR PRODUCING THE SAME 审中-公开
    DIAZABICYCLO [3.3.1]非衍生物及其中间体，其药物用途及其生产方法

    公开(公告)号：WO1996030372A1

    公开(公告)日：1996-10-03

    申请号：PCT/JP1996000742

    申请日：1996-03-21

    Applicant: JAPAN TOBACCO INC. ,  KOBAYASHI, Koji ,  ORITA, Kazuhiro ,  HAMADA, Atsushi ,  INABA, Takashi ,  ABE, Hiroyuki ,  MIYAZAKI, Susumu

    Inventor： JAPAN TOBACCO INC.

    IPC: C07D471/08

    CPC classification number: C07D471/08

    Abstract: Diazabicyclo[3.3.1]nonane derivatives represented by general formula (1), wherein R represents -CONH-(CHR )m-R (wherein R represents hydrogen or alkyl; m is 0, 1 or 2; and R represents optionally substituted aryl, optionally substituted heterocycle, optionally substituted cycloalkyl, alkyl or alkyenyl) or -CO-R [wherein R represents alkyl, aralkyloxy or -NR R {wherein R and R are the same or different and each represents alkyl, or R and R together with the nitrogen atom to which they are bonded from a group (a) (wherein n is 2 or 3)}]; interm ediates thereof; and a nicotinic cholinergic agent containing the diazabicyclo[3.3.1]nonane derivatives. The compounds have a nicotinic cholinergic effect and a dopamine-releasing effect and are usable as a remeddy for dementia such as Alzheimer's disease, a drug for relieving memory disorders, a remedy for central nerve degeneration diseases, and a drug for relieving cerebral function disorders.

    Abstract translation: 由通式（1）表示的二氮杂双环[3.3.1]壬烷衍生物，其中R表示-CONH-（CHR 1）m R 2（其中R 1表示氢或烷基; m是0,1或2 ; R 2代表任选取代的芳基，任选取代的杂环，任选取代的环烷基，烷基或烷基）或-CO-R 3 [其中R 3表示烷基，芳烷氧基或-NR 4 R 5 >其中R 4和R 5相同或不同，并且各自代表烷基，或者R 4和R 5与它们所连接的氮原子一起（a）（其中 n为2或3）}]; 其间; 和含有二氮杂双环[3.3.1]壬烷衍生物的烟碱型胆碱能药剂。 所述化合物具有烟碱性胆碱能作用和多巴胺释放作用，并且可用作痴呆症的补救剂，例如阿尔茨海默氏病，用于缓解记忆障碍的药物，用于中枢神经变性疾病的药物，以及用于缓解脑功能障碍的药物。

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