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    닭전염성기관지염 바이러스 Ｓ1 단백질을 발현하는유전자재조합 마렉바이러스 및 그의 제조방법
    4.
    发明公开
    닭전염성기관지염 바이러스 Ｓ1 단백질을 발현하는유전자재조합 마렉바이러스 및 그의 제조방법 有权
    感染性BRONCHITIS病毒（IBV）的重组MAREK病毒2型（MDV2）及其构建方法

    公开(公告)号：KR1020010095727A

    公开(公告)日：2001-11-07

    申请号：KR1020000019033

    申请日：2000-04-11

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 송창선 ,  이윤정 ,  성환우 ,  한명국 ,  김기석

    IPC: C12N15/63

    CPC classification number: C12N15/63 ,  A61K39/12 ,  C12N7/00

    Abstract: PURPOSE: A recombinant Marek's disease virus type 2(MDV2) expressing the S1 glycoprotein of infectious bronchitis virus(IBV) and its construction methods are provided, to effectively use in preventing the infectious bronchitis of chicken. CONSTITUTION: The Marek's disease virus type 2(MDV2) expression vector pKGFKM contains the S1 glycoprotein gene of infectious bronchitis virus(IBV). The recombinant Marek's disease virus type 2(MDV2) expressing the S1 glycoprotein of infectious bronchitis virus(IBV) rMDV2-US3S1 (KFCC 11154) is prepared by transforming the expression vector pKGFKM. The recombinant Marek's disease virus type 2(MDV2) expressing the S1 glycoprotein of infectious bronchitis virus(IBV) is constructed by co-transfecting Marek's disease virus type 2(MDV2) expression vector pKGFKM containing the S1 glycoprotein gene of infectious bronchitis virus(IBV) and genomic MDV HPRS24 DNA into the CEF cell by using electroporation method.

    Abstract translation: 目的：提供表达感染性支气管炎病毒（IBV）S1糖蛋白的重组马立克氏病病毒2型（MDV2）及其构建方法，有效用于预防鸡传染性支气管炎。 构成：马立克氏病病毒2型（MDV2）表达载体pKGFKM含有感染性支气管炎病毒（IBV）的S1糖蛋白基因。 通过转化表达载体pKGFKM制备表达感染性支气管炎病毒（IBV）rMDV2-US3S1（KFCC 11154）的S1糖蛋白的重组马立克氏病病毒2型（MDV2）。 通过共转染含有感染性支气管炎病毒（IBV）的S1糖蛋白基因的马立克氏病毒2型（MDV2）表达载体pKGFKM构建表达感染性支气管炎病毒（IBV）的S1糖蛋白的重组马立克氏病病毒2型（MDV2） 和基因组MDV HPRS24 DNA通过电穿孔法进入CEF细胞。

    면역원성이 향상된 인플루엔자 바이러스의 ＨＡ2 공통 에피톱의 제조 방법
    6.
    发明公开
    면역원성이 향상된 인플루엔자 바이러스의 ＨＡ2 공통 에피톱의 제조 방법 有权
    制备具有改善免疫原性的流感病毒HA2通用抗原决定基的方法

    公开(公告)号：KR1020140010583A

    公开(公告)日：2014-01-27

    申请号：KR1020120076917

    申请日：2012-07-13

    Applicant: 서울대학교산학협력단 ,  대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 권혁준 ,  김재홍 ,  최준구 ,  이윤정

    IPC: C12N7/01 ,  C12N15/63 ,  C12N15/33 ,  A61K39/145

    Abstract: Provided are: a method for improving immunogenicity of a HA2 common epitope of influenza virus by replacing asparagine, which is the 154th amino acid, and serine (S) or threonine (T), which is the 156the amino acid, with other amino acid such that N-glycan generation does not occur at asparagine (N), which is the 154th amino acid, of a HA2 fragment derived from a HA amino acid of avian influenza virus; and a recombinant virus with improved immunogenicity through the method. The technic for improving immunogenicity of a HA2 common epitope and the HA2 common epitope high immunogenicity virus of the present invention can be effectively used in developing a vaccine strain for preventing influenza and effectively used as a vaccine strain.

    Abstract translation: 提供：通过将作为第154位氨基酸的天冬酰胺和作为氨基酸的156位的丝氨酸（S）或苏氨酸（T）与其它氨基酸这样的氨基酸取代来改善流感病毒的HA2常见表位的免疫原性的方法 来自禽流感病毒的HA氨基酸的HA2片段的第155位氨基酸的天冬酰胺（N）不发生N-聚糖生成; 和通过该方法具有改善的免疫原性的重组病毒。 用于提高本发明的HA2常见表位和HA2常见表位高免疫原性病毒的免疫原性的技术可以有效地用于开发用于预防流行性感冒并有效用作疫苗株的疫苗株。

    발육계란 고증식성, 무병원성 인플루엔자 바이러스 제작용 재조합 발현 벡터
    7.
    发明公开
    발육계란 고증식성, 무병원성 인플루엔자 바이러스 제작용 재조합 발현 벡터 有权
    用于制备高产和流行性流感病毒的重组表达载体及其用途

    公开(公告)号：KR1020140010582A

    公开(公告)日：2014-01-27

    申请号：KR1020120076916

    申请日：2012-07-13

    Applicant: 서울대학교산학협력단 ,  대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 권혁준 ,  김재홍 ,  김일환 ,  최준구 ,  이윤정 ,  강현미

    IPC: C12N7/00 ,  C12N15/33 ,  C12N7/01 ,  C12N15/63

    Abstract: The present invention relates to: a composition for high productiveness of an embryonated egg of H1N1 family avian influenza and non-pathogenicity of a mouse including, as a active ingredient, a polynucleotide encoding a PB2 protein of a low pathogenic avian influenza virus; a recombinant expression vector including the polynucleotide; an attenuated recombinant virus transformed into the expression vector; and a vaccine composition including the recombinant expression vector. The recombinant expression vector of the present invention enhances chicken embryo productivity of a vaccine strain for preventing influenza, and thereby, having advantages of being capable of being effectively used in enhancing efficacy and productivity of killed vaccines, and additionally, has no pathogenicity for mice and has immunogenicity, and thereby having advantages of being capable of being effectively used as live vaccines. [Reference numerals] (AA) Inserting into the inside of pHW2000-BsmBI

    Abstract translation: 本发明涉及一种用于H1N1家禽禽流感的胚胎卵和非致病性的高生产力的组合物，其包含作为活性成分的编码低致病性禽流感病毒的PB2蛋白的多核苷酸; 包含该多核苷酸的重组表达载体; 减毒的重组病毒转化成表达载体; 以及包含重组表达载体的疫苗组合物。 本发明的重组表达载体增强用于预防流感的疫苗株的鸡胚生产力，从而具有能够有效地用于提高杀死疫苗的功效和生产力的优点，此外，对小鼠没有致病性， 具有免疫原性，因此具有能够有效地用作活疫苗的优点。 （标号）（AA）插入pHW2000-BsmBI的内部

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