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    페닐-이속사졸 유도체 및 그의 제조방법
    2.
    发明公开
    페닐-이속사졸 유도체 및 그의 제조방법 有权
    苯丙酸衍生物及其制备方法

    公开(公告)号：KR1020120118665A

    公开(公告)日：2012-10-29

    申请号：KR1020110036172

    申请日：2011-04-19

    Applicant: 일양약품주식회사

    Inventor： 김동연 ,  조대진 ,  이공열 ,  김홍엽 ,  우석훈 ,  이해언 ,  김성무 ,  안충암 ,  윤승빈

    IPC: C07D413/06 ,  A61K31/496 ,  A61P31/16

    CPC classification number: A61K31/496 ,  A61K31/42 ,  A61K31/454 ,  A61K45/06 ,  C07D261/08 ,  C07D261/18 ,  C07D413/06

    Abstract: PURPOSE: A phenyl-isoxazole derivative and a method of manufacture thereof are provided to have influenza virus suppressing activity and to prevent the reproduction of the virus. CONSTITUTION: A phenyl-isoxazole derivative is represented by chemical formula 1. A manufacturing method of a compound of the chemical formula 1 comprises the following steps: manufacturing a compound of chemical formula 5 by reacting a compound of chemical formula 4 with hydroxylammoniumchloride under the presence of base; manufacturing a compound of chemical formula 7 which is isoxazol compound by using cyclization after manufacturing a compound of chemical formula 6 by using chloro reaction; and manufacturing a compound of chemical formula 9a or 9b by reacting with the compound of the chemical formula 2 or 3 after manufacturing a compound of chemical formula 8 by separating R10. The manufacturing method is processed under the presence of a tolerant solvent and/or acid or base.

    Abstract translation: 目的：提供苯基异恶唑衍生物及其制备方法以具有流感病毒抑制活性并防止病毒繁殖。 构成：苯基 - 异恶唑衍生物由化学式1表示。化学式1的化合物的制备方法包括以下步骤：通过使化学式4的化合物与羟基氯化铵在存在下反应来制备化学式5的化合物 的基数 通过使用氯代反应制造化学式6的化合物后，通过使用环化制造化合物7的化合物的化合物，其为异恶唑化合物; 在制造化学式8的化合物之后，通过分离R10，与化学式2或3的化合物反应制备化学式9a或9b的化合物。 该制造方法在耐受溶剂和/或酸或碱的存在下进行处理。

    Ν-페닐-2-피리미딘 이소티오시아네이트 유도체 및 그의 제조방법
    3.
    发明公开
    Ν-페닐-2-피리미딘 이소티오시아네이트 유도체 및 그의 제조방법 无效
    α-苯基-2-吡啶基异硫氰酸酯衍生物及其制备方法

    公开(公告)号：KR1020120052095A

    公开(公告)日：2012-05-23

    申请号：KR1020100113560

    申请日：2010-11-15

    Applicant: 일양약품주식회사

    Inventor： 김동연 ,  조대진 ,  이공열 ,  김홍엽 ,  우석훈 ,  이해언 ,  김성무 ,  안충암

    IPC: C07D239/42 ,  A61K31/505 ,  A61P31/12

    CPC classification number: Y02P20/55 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

    Abstract: PURPOSE: An N-phenyl-2-pyrimidine isothiocyanate derivative compound is provided to suppress influenza virus and to prevent and treat viral infection. CONSTITUTION: An N-phenyl-2-pyrimidine isothiocyanate derivative compound is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of reacting a compound of chemical formula 4a or 4b with a compound of chemical formula 5 to prepare a compound of chemical formula 6a or 6b; and a step of removing PG.

    Abstract translation: 目的：提供N-苯基-2-嘧啶异硫氰酸酯衍生物化合物以抑制流感病毒并预防和治疗病毒感染。 构成：化学式1表示N-苯基-2-嘧啶异硫氰酸酯衍生物化合物。化学式1化合物的制备方法包括：使化学式4a或4b的化合物与化学式 以制备化学式6a或6b的化合物; 以及去除PG的步骤。

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