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公开(公告)号：KR1020080047269A
公开(公告)日：2008-05-28
申请号：KR1020070115941
申请日：2007-11-14
Applicant: 재단법인서울대학교산학협력재단 , 재단법인 제주테크노파크
IPC: C12Q1/68
CPC classification number: C12Q1/689 , C12Q1/6869
Abstract: A method for identifying a pathogenic genus of potato scab is provided to identify the pathogenic genus conveniently and economically with high accuracy by solving problems of a generally used 16S rRNA identification technique and an identification method targeting 16S-23S ITS, thereby being widely used for identifying the pathogenic genus of the potato scab. A method for identifying a pathogenic genus of potato scab comprises the steps of: (a) amplifying an rpoB gene fragment of a target strain using at least one primer selected from the group consisting of a primer including a sequence of SEQ ID : NO. 1 and a primer including a sequence of SEQ ID : NO. 2; (b) analysing the sequence of the amplified rpoB gene fragment; and (c) after multialigning the sequence analyzed by the step(b) by substituting it for a sequence of an rpoB gene selected from the group consisting of sequences of SEQ ID : NOs. 3 to 21 of a standard strain related to the potato scab, completing a genealogy to determine the genus. A method for classifying the pathogenic genus of the potato scab comprises a step of analyzing signature amino acid sequences of 336th and 442nd among an amino acid deduced from the rpoB gene sequence analyzed by the step(b).
Abstract translation: 提供了一种鉴定马铃薯斑纹病病原体的方法，通过解决一般使用的16S rRNA鉴定技术和针对16S-23S ITS的鉴定方法的问题，以高精度方便，经济地识别病原属，从而广泛用于鉴定 马铃薯痂病的病原属。 用于鉴定马铃薯斑纹病的致病属的方法包括以下步骤：（a）使用至少一种选自下组的引物扩增靶菌株的rpoB基因片段：包括SEQ ID NO： 1和包含SEQ ID NO：1的序列的引物。 2; （b）分析扩增的rpoB基因片段的序列; 和（c）通过用步骤（b）分析的序列多重标记选自SEQ ID NO：的序列的rpoB基因的序列后。 3至21个与马铃薯痂病相关的标准菌株，完成家谱以确定属。 用于分类马铃薯斑纹病的致病属的方法包括分析由步骤（b）分析的rpoB基因序列推导的氨基酸中第336位和第442位的特征氨基酸序列的步骤。
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公开(公告)号：KR100959195B1
公开(公告)日：2010-05-24
申请号：KR1020070115941
申请日：2007-11-14
Applicant: 재단법인서울대학교산학협력재단 , 재단법인 제주테크노파크
IPC: C12Q1/68
Abstract: 본 발명은
rpoB 유전자를 이용한 감자 더뎅이 병원성 균종의 동정방법에 관한 것으로서, 더욱 상세하게는 모든 스크렙토마이세스 속 균종의
rpoB 유전자를 증폭시킬 수 있는 특이적 프라이머를 이용하여 감자 더뎅이병과 연관되어 있다고 알려진 표준 균주의
rpoB 유전자를 증폭시킨 후 염기서열을 분석하여 데이터베이스를 구축하고, 이 데이터베이스로 기존의 형태학적 분류법이 갖는 시간, 정확성의 문제점을 해소하며, 또한 요즘 일반적으로 사용되고 있는 16S rDNA 동정법의 갖는 시간, 비용 상의 문제점을 해결하여 간편하고, 경제적이며 정확성이 높은 감자 더뎅이 병 균종을 동정하는 방법에 관한 것이다.
또한, 본 발명은 분석된
rpoB 유전자 염기서열의 추론된(deduced) 아미노산 중 336 번째와 442 번째의 시그네이쳐(signature) 아미노산 염기서열을 분석하여 감자더뎅이 병원성 균종으로 분류하는 방법을 개발함으로써 이 균종의 동정 및 감자더뎅이병 진단에 유용하리라 기대된다.
rpoB 유전자, 감자 더뎅이, 특이적 프라이머, 동정 방법, 336 번째와 442 번째의 시그네이쳐(signature) 아미노산 염기서열-
公开(公告)号：KR1020080084177A
公开(公告)日：2008-09-19
申请号：KR1020070025503
申请日：2007-03-15
Applicant: 재단법인 제주테크노파크 , (주)인터케어
Abstract: Scoria powder is provided to be used as an absorbent of sebum, an improving agent of keratin, a moisturizing agent, an agent of improving acne or an agent of improving atopic dermatitis. A cosmetic composition for absorbing sebum, moisturizing, improving keratin, improving atopic dermatitis or improving acne comprises scoria powder as an effective ingredient. The cosmetic composition is in the form of emulsion, lotion, cream, solution, suspension, an anhydrous product, gel, mask, pack or powder.
Abstract translation: 提供了用作皮脂吸收剂，角蛋白的改善剂，保湿剂，改善痤疮的药剂或改善特应性皮炎的药剂的Scoria粉末。 用于吸收皮脂，保湿，改善角蛋白，改善特应性皮炎或改善痤疮的化妆品组合物包括作为有效成分的粉屑粉末。 化妆品组合物为乳液，洗剂，霜剂，溶液，悬浮液，无水产品，凝胶，面膜，包装或粉末的形式。
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公开(公告)号：KR100883764B1
公开(公告)日：2009-02-18
申请号：KR1020070025503
申请日：2007-03-15
Applicant: 재단법인 제주테크노파크 , (주)인터케어
Abstract: 본 발명은 화산재의 일종인 송이(스코리아) 분말의 용도를 개시한다. 구체적으로는 본 발명은 피지 흡착제, 각질 개선제, 보습제, 여드름 개선제 또는 아토피 피부염 개선제로서의 송이 분말의 용도를 개시한다.
송이 분말, 피지 흡착, 각질 개선, 보습, 여드름, 아토피-
公开(公告)号：KR1020100000025A
公开(公告)日：2010-01-06
申请号：KR1020080059348
申请日：2008-06-24
Applicant: 재단법인 제주테크노파크 , (주)설향 , (주)인터케어
CPC classification number: A61K8/981 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/846 , Y10S530/851
Abstract: PURPOSE: A composition for skin whitening, which contains pig placental extract is provided to suppress melanogenesis and ensure high skin whitening effect with high safety. CONSTITUTION: A composition for skin whitening contains pig placental extract isolated by ultrasonic wave. The placental extract is: an extract obtained by mixing water, ethanol, or their mixture solvent to pig placental powder and irradiating ultrasonic wave; a powder extract which is removed from placental ground material; an extract of supernatant after centrifuging placental ground material; a powder extract obtained by centrifuging placental ground material and removing solvent from the supernatant; an extract of supernatant obtained by filtering placental ground material and centrifuging; and a powder resultant obtained by filtering placental ground material, removing extract, centrifuging, and removing solvent from supernatant. The composition is a cosmetic composition or pharmaceutical composition.
Abstract translation: 目的：提供含有猪胎盘提取物的皮肤美白组合物，以抑制黑色素生成，确保高安全性的高肤色美白效果。 构成：皮肤美白组合物含有通过超声波分离的猪胎盘提取物。 胎盘提取物是通过将水，乙醇或其混合溶剂与猪胎盘粉末混合并照射超声波获得的提取物; 从胎盘研磨材料中除去的粉末提取物; 离心分离胎盘研磨材料后的上清液提取物; 通过离心胎盘研磨材料并从上清液中除去溶剂获得的粉末提取物; 通过过滤胎盘研磨物质并离心得到的上清液提取物; 通过过滤胎盘磨碎物质，去除提取物，离心分离和从上清液中除去溶剂得到的粉末产物。 该组合物是化妆品组合物或药物组合物。
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Patent Agency Ranking
公开(公告)号：KR1020100000026A
公开(公告)日：2010-01-06
申请号：KR1020080059349
申请日：2008-06-24
Applicant: 재단법인 제주테크노파크 , (주)설향
CPC classification number: A61K35/50 , A61K8/981 , A61K41/0014
Abstract: PURPOSE: A composition containing pig placental extract for relieving atopic dermatitis is provided to suppress the expression of MDC(macrophage-derived chemokine) and TARC(thymusand activation-regulated chemokine). CONSTITUTION: A composition for relieving atopic dermatitis contains a pig placental extract by ultra sonic wave, hexane fraction extract of placental extract by water, ethanol, or their mixture solvent or ethylacetate fraction extract of pig placental extract by water, ethanol, or their mixture solvent. The atopic dermatitis is juvenile form atopic dermatitis, young child type atopic dermatitis, adult atopic dermatitis or pregnant women atopic dermatitis. The composition is a pharmaceutical composition or cosmetic composition.
Abstract translation: 目的：提供含有用于缓解特应性皮炎的猪胎盘提取物的组合物，以抑制MDC（巨噬细胞来源的趋化因子）和TARC（胸腺和活化调节的趋化因子）的表达。 构成：用于缓解特应性皮炎的组合物通过超声波包含猪胎盘提取物，通过水，乙醇或其混合溶剂，通过水，乙醇或其混合溶剂或猪胎盘提取物的乙酸乙酯级分提取物的胎盘提取物的己烷级分提取物 。 特应性皮炎是青少年特应性皮炎，幼儿型特应性皮炎，成人特应性皮炎或孕妇特应性皮炎。 该组合物是药物组合物或化妆品组合物。
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公开(公告)号：KR100823113B1
公开(公告)日：2008-04-18
申请号：KR1020070025502
申请日：2007-03-15
Applicant: 재단법인 제주테크노파크 , (주)인터케어
CPC classification number: A61K8/19 , A61Q17/04 , Y10S514/844
Abstract: A UV-protective cosmetic composition is provided to block both UVA and UVB, thereby preventing or alleviating skin cancer, melanogenesis promotion, erythema, freckles and edema caused by the UVA and/or UVB. A cosmetic composition for blocking ultraviolet rays comprises volcanic side product powder selected from the group consisting of scoria, lava ball, lava tree mold, lava tree, lava stalagmite and lava stalagtities as an effective ingredient. The composition further comprises a cosmetically acceptable carrier such as an alcohol, an oil, a surfactant, a fatty acid, a silicone oil, a humectant, a moisturizer, a viscosity modifier, an emulsion, a stabilizer, a UV blocking agent, a coloring agent and a perfume.
Abstract translation: 提供防UV化妆品组合物以阻断UVA和UVB，从而防止或减轻由UVA和/或UVB引起的皮肤癌，黑素生成促进，红斑，雀斑和水肿。 用于阻挡紫外线的化妆品组合物包括选自熔渣，熔岩球，熔岩树模，熔岩石，熔岩石笋和熔岩石笋作为有效成分的火山灰产品粉末。 该组合物还包含美容上可接受的载体，例如醇，油，表面活性剂，脂肪酸，硅油，保湿剂，保湿剂，粘度调节剂，乳液，稳定剂，UV阻断剂，着色剂 代理和香水。
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公开(公告)号：KR1020100036582A
公开(公告)日：2010-04-08
申请号：KR1020080095870
申请日：2008-09-30
Applicant: 재단법인서울대학교산학협력재단
IPC: C12Q1/68
CPC classification number: C12Q1/706 , G01N33/57438 , G01N2033/57461 , G01N2800/085
Abstract: PURPOSE: A kit for diagnosing hepatism derived from hepatitis type B through realtime PCR(polymerase chain reaction) is provided to easily detect mutated HBV preS1 antigen gene which is specific in hepatitis, hepatic cirrhosis, and liver cancer. CONSTITUTION: A kit for diagnosing hepatitis type B and hepatism derived from the hepatitis type B contains a primer having sequences of sequence numbers 1 to 4 and probe having sequences of sequence numbers 5 and 6. The kit for diagnosing hepatitis type B and hepatism derived from the hepatitis type B is used in detecting mutated preS1 antigen gene. Liver disease derived from hepatitis type B is liver cancer or liver cirrhosis.
Abstract translation: 目的：提供通过实时PCR（聚合酶链反应）诊断来自乙型肝炎肝炎的试剂盒，以便于检测肝炎，肝硬化和肝癌特异性的突变型HBV preS1抗原基因。 构成：用于诊断乙型肝炎和乙型肝炎的肝病的试剂盒含有具有序列号1至4的序列的引物和具有序列号5和6的序列的探针。用于诊断乙型肝炎和肝病的试剂盒来源于 B型肝炎用于检测突变的preS1抗原基因。 来自乙型肝炎的肝病是肝癌或肝硬化。
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公开(公告)号：KR100764844B1
公开(公告)日：2007-10-08
申请号：KR1020060042174
申请日：2006-05-11
Applicant: 재단법인서울대학교산학협력재단
Inventor： 김범준
IPC: G01N33/574 , G01N33/576 , G01N33/53
Abstract: A diagnostic kit for hepatic disorder derived from hepatitis B by using a HBV(hepatitis B virus) X antigen is provided to diagnose hepatic disorders including liver cirrhosis and liver cancer as well as hepatitis B by specifically detecting modified X antigen gene derived from HBV(hepatitis B virus) at an early stage. A diagnostic kit for hepatic disorder derived from hepatitis B by using a HBV X antigen comprises primers having the nucleotide sequences of SEQ ID NOs:1-3 and 5 and a restriction enzyme Fok-I. Alternatively, the diagnostic kit for hepatic disorder derived from hepatitis B by using a HBV X antigen contains a DNA chip consisting of (i) gene probes being capable of specifically binding to genes of V5M and H94Y X antigens, and having the nucleotide sequences of SEQ ID NOs: 6 to 13, (ii) a linker containing oligo (dT)15, -(CH2)6- and amine groups sequentially and linked to the 5'-terminal of the gene probes with a thymine site, and (iii) a solid substrate having an aldehyde group, which is linked to the amine group of linker through Schiff's base reaction, on the surface.
Abstract translation: 通过特异性检测来自HBV的修饰的X抗原基因（肝炎），提供通过使用HBV（乙型肝炎病毒）X抗原从乙肝引起的肝脏疾病的诊断试剂盒，用于诊断肝脏疾病，包括肝硬化和肝癌以及乙型肝炎 B病毒）。 通过使用HBV X抗原从乙型肝炎引起的肝脏疾病的诊断试剂盒包括具有SEQ ID NO：1-3和5的核苷酸序列的引物和限制酶Fok-1。 或者，通过使用HBV X抗原从乙型肝炎引起的肝病的诊断试剂盒含有DNA芯片，其包含（i）能够特异性结合V5M和H94Y X抗原的基因的基因探针，并具有SEQ ID NO： ID NOs：6〜13，（ii）连接物，其连接体依次连接到基因探针的5'末端并与胸腺嘧啶位点连接，（iii）含有寡核苷酸（dT）15， - （CH2） 在表面上通过席夫氏碱反应将具有醛基的固体底物与连接体的胺基连接。
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公开(公告)号：KR100758727B1
公开(公告)日：2007-09-14
申请号：KR1020060030113
申请日：2006-04-03
Applicant: 재단법인서울대학교산학협력재단
IPC: C12Q1/68 , G01N33/576 , G01N33/53
CPC classification number: C12Q1/6883 , C12Q1/6827 , C12Q2600/118 , G01N33/5308 , G01N33/5761
Abstract: A composition for diagnosis of the progress of liver disease of a HBV(Hepatitis B Virus) infected patient and a kit containing the same composition are provided to anticipate, diagnose and prevent the progress of liver disease of the HBV infected patient by confirming nucleotide deletion of a preS1 initiation site. A polynucleotide which has base deletions of 15-21 bp(2848th to 2880th bases) in the coding initiation site of preS1 gene of HBV genotype C genome genes having the nucleotide sequence of SEQ ID NO:19, and total 15-400 continuous bases located at both ends of the deletion site is provided, wherein the base deletion is 15bp base deletion from 2849th-2863th bases in the nucleotide sequence of SEQ ID NO:19, 15bp base deletion from 2850th-2864th bases in the nucleotide sequence of SEQ ID NO:19, 21bp base deletion from 2849th-2869th bases in the nucleotide sequence of SEQ ID NO:19, or 21bp base deletion from 2854th-2874th bases in the nucleotide sequence of SEQ ID NO:19. The composition for diagnosis of the progress of liver disease of a HBV infected patient comprises the probe having a nucleotide sequence complementary with the polynucleotide sequence, selected from SEQ ID NOs:9, 10, 11 and 12 to detect the polynucleotide.
Abstract translation: 提供用于诊断HBV（乙型肝炎病毒）感染患者的肝病进展的组合物和含有相同组成的试剂盒，以通过确认HBV感染患者的肝脏疾病的核苷酸缺失来预测，诊断和预防HBV感染患者的肝病进展 preS1启动点。 在具有SEQ ID NO：19的核苷酸序列的HBV基因型C基因组基因的preS1基因的编码起始位点中具有15-21bp（2848至2880个碱基）的碱基缺失的多核苷酸，以及总共15-400个连续碱基 提供缺失位点的两端，其中碱基缺失是SEQ ID NO：19的核苷酸序列中的第2849位至第2863位碱基之间的15bp碱基缺失，SEQ ID NO：1的核苷酸序列中的第2850至第2864位碱基的15bp碱基缺失 SEQ ID NO：19的核苷酸序列中的第2849〜2869位碱基有21bp的碱基缺失或SEQ ID NO：19的核苷酸序列中第2854〜2874位碱基的21bp碱基缺失。 用于诊断HBV感染患者的肝病进展的组合物包括具有与选自SEQ ID NO：9,10,11和12的多核苷酸序列互补的核苷酸序列的探针，以检测多核苷酸。
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