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公开(公告)号：KR1020120080894A
公开(公告)日：2012-07-18
申请号：KR1020110002358
申请日：2011-01-10
Applicant: 전남대학교산학협력단
IPC: A61K31/35 , A61K31/7028 , A61P3/04 , A61P3/10
Abstract: PURPOSE: A human intestine maltase activation inhibitor containing epigallocatechin gallate or epigallocatechin gallate-glucoside is provided to specifically suppress maltase without the activation of pancreatic amylase and to prevent or treat saccharide-associated diseases. CONSTITUTION: A human intestine maltase activation inhibitor contains a compound of chemical formula 1 or 2 as an active ingredient. The compound is prepared by adding glycosyltransferase to a mixture of sucrose and epigallocatechin gallate. The glucosyltransferase is Leuconostoc mesenteroides strain-derived dextran sucrase. A composition for preventing or treating one or more glucose metabolic diseases contains the compound of chemical formula 1 or 2 or a combination compound thereof as an active ingredient. The glucose metabolic disease is diabetes.
Abstract translation: 目的：提供含有表没食子儿茶素没食子酸没食子酸酯或没食子儿茶素没食子酸酯 - 葡萄糖苷的人类肠道麦芽糖激活抑制剂，用于特异性抑制麦芽糖酶而不激活胰淀粉酶并预防或治疗糖相关疾病。 构成：人肠道麦芽糖激活抑制剂含有化学式1或2的化合物作为活性成分。 通过向蔗糖和表没食子儿茶素没食子酸酯的混合物中加入糖基转移酶来制备化合物。 葡萄糖基转移酶是肠系膜梭菌菌株衍生的葡聚糖蔗糖酶。 用于预防或治疗一种或多种葡萄糖代谢疾病的组合物含有化学式1或2的化合物或其组合化合物作为活性成分。 糖代谢疾病是糖尿病。
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公开(公告)号：KR1020120080733A
公开(公告)日：2012-07-18
申请号：KR1020110002123
申请日：2011-01-10
Applicant: 전남대학교산학협력단
IPC: C07D311/32 , C07H7/06 , A61K8/49 , A61Q19/02
Abstract: PURPOSE: A composition containing ampelopsin-glucosides is provided to ensure superior water solubility, to suppress tyrosinase activation, and to improve skin whitening, anti-wrinkling, and anti-aging. CONSTITUTION: An ampelopsin-glucoside is denoted by chemical formula 1. A method for preparing the ampelopsin-glucosides comprises a step of adding glycosyltransferase to a mixture solution of sucrose and ampelopsin. The glycosyltransferase includes Leuconostoc mesenteroides strain-derived dextran sucrase. A composition for improving anti-wrinkling, antioxidation, and anti-wrinkling and promoting alcohol decomposition in the body contains 0.001-20 wt% of the ampelopsin-glucosides as an active ingredient.
Abstract translation: 目的：提供含有安非他酮 - 葡糖苷的组合物以确保优异的水溶性，抑制酪氨酸酶活化，并改善皮肤美白，抗皱和抗衰老。 构成：氨普糖苷 - 葡萄糖苷由化学式1表示。制备胰岛素 - 葡糖苷的方法包括向蔗糖和安非他酮的混合溶液中加入糖基转移酶的步骤。 糖基转移酶包括肠系膜梭菌菌株衍生的葡聚糖蔗糖酶。 用于改善身体抗皱，抗氧化，抗皱和促进酒精分解的组合物含有0.001-20重量％的安非他酮 - 葡糖苷作为活性成分。
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公开(公告)号：KR1020110069566A
公开(公告)日：2011-06-23
申请号：KR1020090126350
申请日：2009-12-17
Applicant: 전남대학교산학협력단 , 주식회사 제노포커스
CPC classification number: C12P19/44 , C07H15/203
Abstract: PURPOSE: A hydroquinone-beta-D-galactoside which is a hydroquinone derivative is provided to ensure excellent antioxidative ability and to suppress tyrosinase activity. CONSTITUTION: A hydroquinone-beta-D-galactoside is denoted by chemical formula 1. A method for preparing the hydroquinone-beta-D-galactoside comprises: a step of reacting hydroquinone and lactose under the presence of lactase to prepare hydroquinone-beta-D-galactoside; and a step of preparing hydroquinone-beta-D-galactoside. The lactase is derived from Kluyveromyces lactis, Aspergillus oryzae, Bacillus circulans, or Thermus sp. An antioxidative composition contains the hydroquinone-beta-D-galactoside as an active ingredient. The composition is used for whitening or anti-aging.
Abstract translation: 目的：提供氢醌-β-D-半乳糖苷，其为氢醌衍生物，以确保优异的抗氧化能力和抑制酪氨酸酶活性。 构成：氢醌-β-D-半乳糖苷由化学式1表示。一种制备氢醌-β-D-半乳糖苷的方法包括：在乳糖酶存在下使对苯二酚和乳糖反应制备氢醌-β-D 半乳糖苷; 和制备氢醌-β-D-半乳糖苷的步骤。 乳糖酶衍生自乳酸克鲁维酵母，米曲霉，环状芽孢杆菌或栖热菌属。 抗氧化组合物含有氢醌-β-D-半乳糖苷作为活性成分。 该组合物用于美白或抗衰老。
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公开(公告)号：KR101213219B1
公开(公告)日：2012-12-17
申请号：KR1020090126350
申请日：2009-12-17
Applicant: 전남대학교산학협력단 , 주식회사 제노포커스
Abstract: 본발명에의한하이드로퀴논-베타-디-갈락토사이드는자연계의베타-알부틴보다항산화능력이우수하며, 멜라닌색소를형성하는타이로시나아제의활성을저해하는특성이뛰어나미백및 노화방지등의기능성화장품및 의약품산업등에유용하게사용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120070682A
公开(公告)日：2012-07-02
申请号：KR1020100132100
申请日：2010-12-22
Applicant: 전남대학교산학협력단
IPC: C07D407/12 , C07H17/075 , C12P19/14 , A61Q19/00
Abstract: PURPOSE: A composition containing an astragalin derivative is provided to suppress MMP-1 expression and to suppress melanogenesis. CONSTITUTION: An astragalin derivative is denoted by chemical formula 1. The derivative is prepared by adding glycosyltransferase to a solution containing 0.01-1.0 M of sucrose such that the final active concentration is 0.1-100 U/ml, adding astragalin in a reactor at 15-70deg. C. The glycosyltransferase is Leuconostoc mesenteroides-derived dextran sucrase. A composition for enhancing antioxidant activity contains the derivative as an active ingredient. A composition for skin whitening contains the derivative as an active ingredient. The content of the derivative is 0.001-20 wt%.
Abstract translation: 目的：提供含有黄芪素衍生物的组合物以抑制MMP-1的表达并抑制黑素生成。 组成：黄芪灵衍生物由化学式1表示。衍生物通过向含有0.01-1.0M蔗糖的溶液中加入糖基转移酶制备，使得最终活性浓度为0.1-100U / ml，在反应器中加入黄芪素15 -70deg。 C.糖基转移酶是肠系膜梭菌衍生的葡聚糖蔗糖酶。 用于增强抗氧化活性的组合物含有作为活性成分的衍生物。 用于皮肤美白的组合物含有作为活性成分的衍生物。 衍生物的含量为0.001-20重量％。
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公开(公告)号：KR101381590B1
公开(公告)日：2014-04-10
申请号：KR1020110002358
申请日：2011-01-10
Applicant: 전남대학교산학협력단
IPC: A61K31/35 , A61K31/7028 , A61P3/04 , A61P3/10
Abstract: 본 발명은 인간 소장 말타아제의 활성 저해제에 관한 것으로, 보다 상세하게는 에피갈로카테킨 갈레이트 또는 에피갈로카테킨갈레이트-글루코사이드을 유효성분으로 하는 인간 소장 말타아제의 활성저해제 및 이의 조성물에 관한 것으로, 본 발명에 따른 인간 소장 말타아제는 사람의 췌장 아밀라아제의 활성은 저해하지 않고, 혈당을 직접적으로 증가시키는 효소인 말타아제만을 특이적으로 저해하는 장점으로 인해 식후 고혈당의 억제 및 당뇨병 치료제로 당대사 관련 질환을 예방 또는 치료용으로 유용하게 활용될 수 있다.
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公开(公告)号：KR101341017B1
公开(公告)日：2013-12-12
申请号：KR1020110002123
申请日：2011-01-10
Applicant: 전남대학교산학협력단
IPC: C07D311/32 , C07H7/06 , A61K8/49 , A61Q19/02
Abstract: 본 발명은 암페롭신 배당체 및 이를 함유하는 조성물에 관한 것으로, 상기 본 발명의 암페롭신 배당체는 효소를 이용하여 효율적으로 다량의 암페롭신 배당체를 제조할 수 있는 장점 뿐 아니라 상기 제조방법으로 제조된 암페롭신 배당체는 자연계 식물에 존재하는 암페롭신에 비해 우수한 수용성, 수용성 대비 항산화 능력과 알코올 분해효소의 활성을 촉진시키는 능력, 수용액 상태에서의 갈변 억제능, 타이로시네이즈의 활성 억제능을 가지고 있어 피부 미백 및 주름 개선, 노화 방지에 탁월한 효과로 기능성 화장품 소재 및 기능성 식품 그리고 의약품 소재에 크게 기여할 것이다.
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公开(公告)号：KR101262014B1
公开(公告)日：2013-05-08
申请号：KR1020100132100
申请日：2010-12-22
Applicant: 전남대학교산학협력단
IPC: C07D407/12 , C07H17/075 , C12P19/14 , A61Q19/00
Abstract: 본발명은아스트라갈린유도체및 이를함유하는조성물에관한것으로, 보다상세하게는아스트라갈린글루코사이드및 아스트라갈린이소말토올리고당의아스트라갈린유도체의제조방법및 이를함유하는피부개선용조성물에관한것으로, 상기본 발명에따른아스트라갈린유도체의제조방법은효소를이용하여효율적으로다량의아스트라갈린유도체를제조할수 있는장점뿐 아니라상기제조방법으로제조된아스트라갈린유도체는연계식물에존재하는아스트라갈린에비해우수한세포내 콜라겐분해효소 MMP-1의발현억제, 항산화활성증진및 멜라닌생성저해능을가지고있어, 피부미백및 주름개선, 노화방지에탁월한효과로기능성화장품소재에크게기여할것이다.
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公开(公告)号：KR101199821B1
公开(公告)日：2012-11-09
申请号：KR1020110061068
申请日：2011-06-23
Applicant: 전남대학교산학협력단
CPC classification number: C12P19/44 , C07H15/256 , C12P19/18 , C12Y204/01005
Abstract: PURPOSE: A method for preparing stevioside oligo glycoside using glycosyltransferase is provided to relieve bitter and astringent taste and to improve anti-diabetes, anti-hypertension, anti-tumor, and anti-viral functions. CONSTITUTION: A method for preparing glycosyltransferation compounds comprises: a step of putting glycosyltransferase into a solution containing 0.05-1.5 M sugar in a reactor by 0.05-3.0 U/ml of initial active concentration; a step of adding stevioside to the reactor and reacting at 15-50 Deg. C.; a step of transferring glucose of the sugar into a receptor and synthesizing one or more stevioside oligo glycoside selected from chemical formulas 1-3; a step of isolating and purifying the glycosylation compounds. The glycosyltransferase is detran sucrase. The dextran sucrose is Leuconostoc mesenteroides B-512FMCM.
Abstract translation: 目的：提供使用糖基转移酶制备甜菊苷寡糖苷的方法，以缓解苦味和涩味，改善抗糖尿病，抗高血压，抗肿瘤和抗病毒功能。 构成：制备糖基转移化合物的方法包括：在反应器中将糖基转移酶置于含有0.05-1.5M糖的溶液中，步骤为0.05-3.0U / ml初始活性浓度; 将甜菊糖添加到反应器中并在15-50度下反应的步骤。 C。; 将糖的葡萄糖转移入受体并合成一种或多种选自化学式1-3的甜菊苷寡糖苷的步骤; 分离和纯化糖基化化合物的步骤。 糖基转移酶是蔗糖蔗糖酶。 葡聚糖蔗糖是肠系膜梭菌B-512FMCM。
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