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公开(公告)号：KR101322937B1
公开(公告)日：2013-10-28
申请号：KR1020110147201
申请日：2011-12-30
Applicant: 한국식품연구원
IPC: A61K31/353 , A61K9/08 , A61P17/00
Abstract: 본 발명은 어랩틴(Auraptene)을 유효성분으로 함유하는 신생혈관 촉진용 약학조성물에 관한 것으로, 본 발명에 의한 신생혈관 촉진용 약학조성물은 유효성분인 어랩틴에 의해 혈관 신생을 촉진시켜 피부판 재생, 상처 및 화상치유, 인공피부이식 및 이식용 혈관 제조 등의 조직 재생에 효과적이다.
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公开(公告)号：KR1020130078326A
公开(公告)日：2013-07-10
申请号：KR1020110147201
申请日：2011-12-30
Applicant: 한국식품연구원
IPC: A61K31/353 , A61K9/08 , A61P17/00
Abstract: PURPOSE: A pharmaceutical composition containing auraptene as an active ingredient for promoting angiogenesis is provided to promote angiogenesis by auraptene, and to effectively regenerate tissues through skin flap regeneration, wound and burn healing, and artificial skin transplantation. CONSTITUTION: A pharmaceutical composition for promoting angiogenesis contains 1-10 micromole of auraptene as an active ingredient. Auraptene promotes tissue regeneration. The pharmaceutical composition is used for skin flap regeneration, wound and burn healing, artificial skin transplantation, or preparation of blood vessels for transplantation. A food composition for promoting angiogenesis contains auraptene as an active ingredient. Auraptene promotes angiogenesis. [Reference numerals] (AA) Control group; (BB) Auraptene 1μM; (CC) Auraptene 5μM; (DD) Auraptene 10μM; (EE) Auraptene 40μM
Abstract translation: 目的：提供含有紫罗烯作为促进血管发生的活性成分的药物组合物，用于促进紫罗烯烯的血管生成，并通过皮瓣再生，伤口和烧伤愈合以及人造皮肤移植有效地再生组织。 构成：用于促进血管发生的药物组合物含有1-10微摩尔的奥来哌啶作为活性成分。 Auraptene促进组织再生。 药物组合物用于皮瓣再生，伤口和烧伤愈合，人造皮肤移植或用于移植的血管制备。 用于促进血管生成的食品组合物含有作为活性成分的紫罗烯。 Auraptene促进血管生成。 （附图标记）（AA）对照组; （BB）Auraptene1μM; （CC）Auraptene5μM; （DD）Auraptene10μM; （EE）Auraptene40μM
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公开(公告)号：KR1020130078309A
公开(公告)日：2013-07-10
申请号：KR1020110147176
申请日：2011-12-30
Applicant: 한국식품연구원
IPC: A61K31/35 , A61K31/352 , A61P11/02
Abstract: PURPOSE: A pharmaceutical composition containing luteolin as an active ingredient for preventing and treating hyperosmia is provided to suppress recognition of disgusting smell from various olfactory stimulants by suppressing or reducing cyclic AMP (cAMP) generation, thereby effectively preventing and treating hyperosmia. CONSTITUTION: A pharmaceutical composition for preventing and treating hyperosmia contains luteolin as an active ingredient. Luteolin reduces cAMP concentration. The pharmaceutical composition is manufactured in a formulation selected from a group consisted of an oral formulation, an external use formulation, a suppository, a sterilized injection solution, and a spray. A health functional food for preventing and alleviating hyperosmia contains luteolin as an active ingredient. An aroma composition contains luteolin as an active ingredient.
Abstract translation: 目的：提供含有木犀草素作为预防和治疗高血压的有效成分的药物组合物，通过抑制或减少环AMP（cAMP）的产生来抑制各种嗅觉兴奋剂对恶心呕吐的认识，从而有效预防和治疗高血糖。 构成：用于预防和治疗高血糖的药物组合物含有木犀草素作为活性成分。 木犀草素降低cAMP浓度。 药物组合物以选自口服制剂，外用制剂，栓剂，灭菌注射液和喷雾剂的组合物制成。 用于预防和缓解高血糖症的健康功能食品含有木犀草素作为活性成分。 芳香组合物含有木犀草素作为活性成分。
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Patent Agency Ranking4.发明公开바이오케닌에이 또는 약리학적으로 허용되는 이의 염을 활성성분으로 함유하는 신생혈관생성과 관련된 질환의 치료용 조성물 无效用于治疗与包含生物素或其药学上接受的药物的血管生成相关的疾病的组合物
公开(公告)号：KR1020120029557A
公开(公告)日：2012-03-27
申请号：KR1020100091411
申请日：2010-09-17
Applicant: 한국식품연구원
IPC: A61K31/352 , A61K36/48 , A61P35/00 , A61P27/02
Abstract: PURPOSE: A composition containing biochanin A or pharmaceutically acceptable salt thereof for treating angiogenesis-associated diseases is provided to treat various diseases. CONSTITUTION: A composition for treating angiogenesis-associated diseases contains biochanin A or pharmaceutically acceptable salt thereof as an active ingredient. The angiogenesis-associated diseases are cancer, diabetetic retinopathy, rheumatic arthritis, psoriasis, inflammation, endometriosis, aging or hemandioma. A pharmaceutical composition for suppressing angiogenesis contains biochanin A or pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供含有角鲨他汀A或其药学上可接受的盐用于治疗血管生成相关疾病的组合物以治疗各种疾病。 构成：用于治疗血管生成相关疾病的组合物含有作为活性成分的角鲨他汀A或其药学上可接受的盐。 血管生成相关疾病是癌症，糖尿病性视网膜病变，风湿性关节炎，牛皮癣，炎症，子宫内膜异位症，衰老或血管瘤。 用于抑制血管发生的药物组合物含有作为活性成分的角鲨他汀A或其药学上可接受的盐。
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5.发明公开
公开(公告)号：KR1020120015221A
公开(公告)日：2012-02-21
申请号：KR1020100077551
申请日：2010-08-11
Applicant: 한국식품연구원
Abstract: PURPOSE: A composition containign sesamol or pharmaceutically acceptable salt is provided to suppress angiogenesis and to treat cancer, diabetic retinopathy, rheumatic arthritis, and psoriasis. CONSTITUTION: A composition for treating angiogenesis-associated diseases contains sesemol or pharmaceutically acceptable salt thereof as an active ingredient. The angiogenesis-associated diseases are cancer, diabetic retinopaghy, rheumatic arthritis, psoriasis, inflammation, endometriosis, and hemandioma. The sesamol or pharmaceutically acceptable salt thereof is contained in 0.1-10 wt%.
Abstract translation: 目的：提供含有塞萨莫酚或药学上可接受的盐的组合物以抑制血管生成并治疗癌症，糖尿病性视网膜病变，风湿性关节炎和牛皮癣。 构成：用于治疗血管生成相关疾病的组合物含有作为有效成分的西昔莫或其药学上可接受的盐。 血管生成相关疾病是癌症，糖尿病视网膜病，风湿性关节炎，牛皮癣，炎症，子宫内膜异位症和血管瘤。 芝麻酚或其药学上可接受的盐含量为0.1-10重量％。
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公开(公告)号：KR101392177B1
公开(公告)日：2014-05-08
申请号：KR1020120147631
申请日：2012-12-17
Applicant: 한국식품연구원
IPC: A61K31/404 , A61P11/02
CPC classification number: A61K31/404 , A23L33/10 , A23V2002/00 , A23V2200/30
Abstract: The present invention relates to a pharmaceutical composition comprising 3,3′-diindolylmathane as an active ingredient for preventing and treating hyperosmia. The pharmaceutical composition according to the present invention can suppress recognition of repulsive smells among a variety of olfactory stimulating materials by inhibiting or reducing generation of cAMP caused by the olfactory stimulation, thereby effective preventing and treating hyperosmia.
Abstract translation: 本发明涉及包含3,3'-二吲哚基甲烷作为预防和治疗高血糖的活性成分的药物组合物。 根据本发明的药物组合物可以通过抑制或减少由嗅觉刺激引起的cAMP的产生而抑制各种嗅觉刺激材料中的排斥气味的识别，从而有效地预防和治疗高血糖。
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公开(公告)号：KR1020140043263A
公开(公告)日：2014-04-09
申请号：KR1020120107317
申请日：2012-09-26
Applicant: 한국식품연구원
IPC: A61K36/342 , A61P9/00
CPC classification number: A61K36/185 , A23L33/105 , A23V2002/00 , A23V2200/30
Abstract: The present invention relates to a composition for anti-angiogenesis comprising a Boehmeria nivea extract as an active ingredient. The Boehmeria nivea extract according to the present invention inhibits a formation of tube on vascular endothelial cells and has no toxicity, thereby capable of being used as a composition comprising the same as an active ingredient for preventing and treating angiogenesis related diseases. [Reference numerals] (AA) Control group; (BB) Ramie-ethanol (μg/ml)
Abstract translation: 本发明涉及一种用于抗血管生成的组合物，其包含勃列布氏菌提取物作为活性成分。 根据本发明的Boehmeria nivea提取物抑制血管内皮细胞上的管形成并且没有毒性，从而能够用作包含其作为预防和治疗血管生成相关疾病的活性成分的组合物。 （附图标记）（AA）对照组; （BB）苎麻 - 乙醇（μg/ ml）
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8.发明授权
公开(公告)号：KR101212925B1
公开(公告)日：2012-12-14
申请号：KR1020100077551
申请日：2010-08-11
Applicant: 한국식품연구원
Abstract: 본발명은세사몰또는약학적으로허용되는이의염을유효성분으로함유하는신생혈관생성과관련된질환의치료용조성물을제공한다. 본발명에따른치료용조성물은신생혈관의생성을억제함으로써이로인해야기되어지는각종질환, 예를들어암, 암, 당뇨성망막병증, 류마티스성관절염, 건선, 염증, 자궁내막증, 노화에따른시력감퇴, 혈관종의치료에효과적이다.
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