公开(公告)号：WO2009149189A3

公开(公告)日：2010-03-04

申请号：PCT/US2009046137

申请日：2009-06-03

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  ISAKSON PETER C ,  OLSON LISA M ,  WU CHENGBIN ,  HUGUNIN MARGARET ,  KAMATH RAJESH V ,  CUFF CAROLYN A ,  ALLEN HAMISH J

Inventor： GHAYUR TARIQ ,  ISAKSON PETER C ,  OLSON LISA M ,  WU CHENGBIN ,  HUGUNIN MARGARET ,  KAMATH RAJESH V ,  CUFF CAROLYN A ,  ALLEN HAMISH J

IPC: C07K16/20 ,  C07K16/46 ,  C12P21/08

CPC classification number: C07K16/2887 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/48546 ,  A61K47/6845 ,  A61K2039/505 ,  A61K2039/70 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/247 ,  C07K16/248 ,  C07K16/2866 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

公开(公告)号：WO2005110410A3

公开(公告)日：2007-03-29

申请号：PCT/US2005016903

申请日：2005-05-13

Applicant: ABBOTT LAB ,  CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

Inventor： CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

IPC: C07D471/02 ,  A61K31/4743 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：EP1753428A4

公开(公告)日：2010-09-15

申请号：EP05778736

申请日：2005-05-13

Applicant: ABBOTT LAB

Inventor： CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

IPC: C07D471/02 ,  A61K31/4743 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

公开(公告)号：EP2297209A4

公开(公告)日：2012-08-01

申请号：EP09759348

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  ISAKSON PETER C ,  OLSON LISA M ,  WU CHENGBIN ,  HUGUNIN MARGARET ,  KAMATH RAJESH V ,  CUFF CAROLYN A ,  ALLEN HAMISH J

IPC: C07K16/46 ,  C07K16/20 ,  C12P21/08

CPC classification number: C07K16/2887 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/48546 ,  A61K47/6845 ,  A61K2039/505 ,  A61K2039/70 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/247 ,  C07K16/248 ,  C07K16/2866 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：AU2009256250A1

公开(公告)日：2009-12-10

申请号：AU2009256250

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： ISAKSON PETER C ,  KAMATH RAJESH V ,  ALLEN HAMISH J ,  GHAYUR TARIQ ,  OLSON LISA M ,  HUGUNIN MARGARET ,  WU CHENGBIN ,  CUFF CAROLYN A

IPC: C07K16/00 ,  A61K39/395 ,  C07H21/04 ,  C07K16/20 ,  C07K16/46 ,  C12N1/10 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C12P21/08

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：MXPA06013250A

公开(公告)日：2007-02-28

申请号：MXPA06013250

申请日：2005-05-13

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ERICSSON ANNA M ,  CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  YU ZHENGTIAN

IPC: A61K31/4743 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02

Abstract: Un compuesto o sales farmaceuticamente aceptables del mismo de la Formula (I), en donde los sustituyentes son como se definen en la presente, los cuales son utiles como inhibidores de quinasa.

公开(公告)号：MX2010013239A

公开(公告)日：2011-02-24

申请号：MX2010013239

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： ALLEN HAMISH J ,  WU CHENGBIN ,  CUFF CAROLYN A ,  GHAYUR TARIQ ,  ISAKSON PETER C ,  OLSON LISA M ,  HUGUNIN MARGARET ,  KAMATH RAJESH V

IPC: C07K16/20 ,  C07K16/46 ,  C12P21/08

Abstract: La presente invención se refiere a proteínas de unión multivalentes y multiespecíficas diseñadas por ingeniería, métodos de fabricación, y específicamente a sus usos en la prevención, diagnóstico, y/o tratamiento de enfermedades.

公开(公告)号：SG191639A1

公开(公告)日：2013-07-31

申请号：SG2013042916

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  ISAKSON PETER C ,  OLSON LISA M ,  WU CHENGBIN ,  HUGUNIN MARGARET ,  KAMATH RAJESH V ,  CUFF CAROLYN A ,  ALLEN HAMISH J

Abstract: DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF AbstractThe present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. Figure 1

公开(公告)号：CA2726087A1

公开(公告)日：2009-12-10

申请号：CA2726087

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  ISAKSON PETER C ,  OLSON LISA M ,  WU CHENGBIN ,  HUGUNIN MARGARET ,  KAMATH RAJESH V ,  CUFF CAROLYN A ,  ALLEN HAMISH J

IPC: C07K16/46 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C12N15/00 ,  C12N15/13 ,  C12P21/00

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：CA2566158A1

公开(公告)日：2005-11-24

申请号：CA2566158

申请日：2005-05-13

Applicant: ABBOTT LAB

Inventor： BISCHOFF AGNIEZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GORDON THOMAS D ,  YU ZHENGTIAN ,  WISHART NEIL ,  ROTH GREGORY P ,  WALLACE GRIER A ,  BARBERIS CLAUDE E ,  GEORGE DAWN M ,  TALANIAN ROBERT V ,  SALMERON-GARCIA JOSE-ANDRES ,  CUSACK KEVIN ,  ALLEN HAMISH J ,  THOMAS CHRISTINE

IPC: A61K31/4743 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02