公开(公告)号：IE921690A1

公开(公告)日：1992-12-02

申请号：IE921690

申请日：1992-07-01

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  ARNERIC STEPHEN P ,  LIN NAN-HORNG ,  JR GEORGE M CARRERA ,  SHUE YOUE-KONG ,  HE YUN

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：IE920365A1

公开(公告)日：1992-08-26

申请号：IE920365

申请日：1992-02-04

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  JR GEORGE M CARRERA ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D409/00 ,  C07D417/00

Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.