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公开(公告)号：DE69735710T2
公开(公告)日：2007-03-29
申请号：DE69735710
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD A , HUTCHINS W , JAE HWAN-SOO , TASKER S , VON GELDERN W , KESTER A , SORENSEN K , SZCZEPANKIEWICZ G , HENRY J , LIU GANG , WITTENBERGER J , KING A
IPC: C07D405/04 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572 , C07F9/59
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：DE69925508T2
公开(公告)日：2006-05-04
申请号：DE69925508
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD A , JAE HWAN-SOO , LYNCH K , ZHU GUI-DONG , FREEMAN C , GUNAWARDANA W , STAEGER A
IPC: C07C323/00 , C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：DE69714024T2
公开(公告)日：2003-03-20
申请号：DE69714024
申请日：1997-02-10
Applicant: ABBOTT LAB
Inventor： TASKER S , BOYD A , SORENSEN K , WINN MARTIN , JAE HWAN-SOO , VON GELDERN W , HENRY J
IPC: A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/675 , A61P1/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07F9/572
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公开(公告)号：DE69735710D1
公开(公告)日：2006-05-24
申请号：DE69735710
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD A , HUTCHINS W , JAE HWAN-SOO , TASKER S , VON GELDERN W , KESTER A , SORENSEN K , SZCZEPANKIEWICZ G , HENRY J , LIU GANG , WITTENBERGER J , KING A
IPC: C07D405/04 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572 , C07F9/59
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：DE60013575T2
公开(公告)日：2005-09-22
申请号：DE60013575
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD A , ZHU GUI-DONG , FREEMAN C , GUNAWARDANA W , STAEGER A , JAE HWAN-SOO , LYNCH K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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Patent Agency Ranking
公开(公告)号：DE69925508D1
公开(公告)日：2005-06-30
申请号：DE69925508
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD A , JAE HWAN-SOO , LYNCH K , ZHU GUI-DONG , FREEMAN C , GUNAWARDANA W , STAEGER A
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：DE69527072T2
公开(公告)日：2003-02-13
申请号：DE69527072
申请日：1995-08-04
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD A , HUTCHINS W , JAE HWAN-SOO , TASKER S , VONGELDERN W , KESTER A , SORENSEN K
IPC: A61K31/40 , A61K31/402 , A61K31/4025 , A61K31/403 , A61K31/41 , A61K31/415 , A61K31/422 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/14 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/04 , C07D419/04 , C07D471/04 , C07F9/572 , C07F9/59
Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
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公开(公告)号：DE60013575D1
公开(公告)日：2004-10-14
申请号：DE60013575
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD A , ZHU GUI-DONG , FREEMAN C , GUNAWARDANA W , STAEGER A , JAE HWAN-SOO , LYNCH K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：DE69714024D1
公开(公告)日：2002-08-22
申请号：DE69714024
申请日：1997-02-10
Applicant: ABBOTT LAB
Inventor： TASKER S , BOYD A , SORENSEN K , WINN MARTIN , JAE HWAN-SOO , VON GELDERN W , HENRY J
IPC: A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/675 , A61P1/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07F9/572
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公开(公告)号：DE69527072D1
公开(公告)日：2002-07-18
申请号：DE69527072
申请日：1995-08-04
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD A , HUTCHINS W , JAE HWAN-SOO , TASKER S , VONGELDERN W , KESTER A , SORENSEN K
IPC: A61K31/40 , A61K31/402 , A61K31/4025 , A61K31/403 , A61K31/41 , A61K31/415 , A61K31/422 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/14 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/04 , C07D419/04 , C07D471/04 , C07F9/572 , C07F9/59
Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
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