Patent search ap:("ABBOTT LAB") AND inv:"XIN ZHILI" Page 1

1.

发明申请
PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES 审中-公开
Title translation: 吡啶衍生物作为C-JUN N-TERMINAL KINASES的抑制剂有用

公开(公告)号：WO2006083673A3

公开(公告)日：2006-12-21

申请号：PCT/US2006002789

申请日：2006-01-24

Applicant: ABBOTT LAB , LIU GANG , SHAM HING L , SZCZEPANKIEWICZ BRUCE G , XIN ZHILI , ZHAO HONGYU , SERBY MICHAEL D , LIU BO , LIU MEI

Inventor： LIU GANG , SHAM HING L , SZCZEPANKIEWICZ BRUCE G , XIN ZHILI , ZHAO HONGYU , SERBY MICHAEL D , LIU BO , LIU MEI

IPC: C07D213/85 , A61K31/44 , A61P3/00 , A61P19/00 , A61P25/00 , C07D213/73 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12

CPC classification number: C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10

Abstract: The present invention relates to compounds of formula (I), that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

Abstract translation: 本发明涉及式（I）化合物，其为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂，含有该化合物的组合物和该化合物在预防或治疗由JNK1，JNK2和JNK3激活调节的疾病。

2.

发明申请
AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS 审中-公开
Title translation: 氨基酸（OXO）乙酸蛋白酪氨酸磷酸酯酶抑制剂

公开(公告)号：WO0218323A3

公开(公告)日：2002-06-27

申请号：PCT/US0126906

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： LIU GANG , SZCZEPANKIEWICZ BRUCE G , PEI ZHONGHUA , XIN ZHILI , OOST THORSTEN K , JANOWICK DAVID A

IPC: A61P3/10 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18 , A61K31/357 , A61K31/404 , A61K31/535 , C07D209/30 , C07D239/04 , C07D319/10

CPC classification number: C07D295/185 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D319/18

Abstract: Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.

Abstract translation: 式（I）化合物或其治疗上可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。

3.

发明申请
CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 审中-公开
Title translation: 细胞粘附抑制抗炎和免疫抑制化合物

公开(公告)号：WO0039081A3

公开(公告)日：2001-05-25

申请号：PCT/US9931162

申请日：1999-12-29

Applicant: ABBOTT LAB

Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD STEVEN A , JAE HWAN-SOO , LYNCH JOHN K , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A

IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/10 , A61K31/33 , C07D295/20

CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10

Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Abstract translation: 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。

4.

发明公开
INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME 有权
Title translation: 抑制剂二酰基甘油O-酰基转移酶1型酶

公开(公告)号：EP2117526A4

公开(公告)日：2011-07-27

申请号：EP07854765

申请日：2007-11-26

Applicant: ABBOTT LAB

Inventor： SOUERS ANDREW J , GAO JU , HANSEN TODD MATTHEW , IYENGAR RAJESH R , KYM PHILIP R , LIU BO X , PEI ZHONGHUA , YEH VINCE , ZHAO GANG , XIN ZHILI

IPC: A61K31/17 , A61P1/16 , A61P3/00 , C07C229/40 , C07D231/20 , C07D263/48 , C07D277/38 , C07D403/04 , C07D405/04 , C07D487/04

CPC classification number: C07D487/04 , C07C59/54 , C07C275/42 , C07D211/60 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/48 , C07D277/40 , C07D401/04 , C07D407/12 , C07D407/14 , C07D413/12 , C07D413/14

5.

发明专利
Inhibidores de enzima diacilglicerol O-aciltransferasa de tipo 1 未知

公开(公告)号：ES2392117T3

公开(公告)日：2012-12-04

申请号：ES08747140

申请日：2008-04-30

Applicant: ABBOTT LAB

Inventor： LIU GANG , XIN ZHILI , KYM PHILIP R , SOUERS ANDREW J

IPC: C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10

Abstract: Un compuesto que tiene la fórmula (I)o una sal farmacéuticamente aceptable del mismo, en la queR1 es hidrógeno o alquilo;R2 es hidrógeno, halógeno, alquilo, haloalquilo, arilo, heteroarilo, cicloalquilo o heterociclo;R3 es cicloalquilo, arilo, heteroarilo, heterociclo, -(CRaRb)m-R4, -C(O)OR5, -C(R5)>=N-O(RV), -C(O)-R5 o -C(O)-N(R5)(R6);m es 1, 2, 3 ó 4;Ra, en cada caso, es independientemente hidrógeno, halógeno, alquilo, alquenilo, haloalquilo, -OR7a, -N(R8)(R9),-C(O)OR7b, -C(O)-R7b, -C(O)-N(R8)(R9), -(CRcRd)p-OR7a, -(CRcRd)p-N(R8)(R9), -(CRcRd)p-C(O)0R7b, -(CRcRd)p-C(O)-R7b, -(CRcRd)p-C(O)-N(R8)(R9), arilo, heteroarilo, cicloalquilo o heterociclo;Rb, en cada caso, es independientemente hidrógeno, halógeno, alquilo, alquenilo, haloalquilo, -C(O)OR7b, -C(O)-R7b, -C(O)-N(R8)(R9), -(CRcRd)p-OR7a, -(CRcRd)p-N(R8)(R9), -(CRcRd)p-C(O)OR7b, -(CRcRd)p-C(O)-R7b, -(CRcRd)p-C(O)-N(R8)(R9), arilo, heteroarilo, cicloalquilo o heterociclo.

6.

发明专利
مثبطات بروتين تيروسين فسفاتاز من حمض امينو (اكسو) اسيتيك 未知

公开(公告)号：SA01220501A

公开(公告)日：2005-12-03

申请号：SA01220501

申请日：2001-10-31

Applicant: ABBOTT LAB

Inventor： LIU GANG , SZCZEPANKIEWICZ BRUCE , PEI ZHONGHUA , XIN ZHILI , OOST THORSTEN K , JANOWICK DAVID A

Abstract: يتعلقالاختراعالراهنبمركباتبالصيغة (١):أوأملاحهاالمقبولةعلاجياوالتيتمثلمثبطاتبروتينتيروسينفسفاتاز PTPIB،وبتحضيرالمركباتوالتراكيبالتيتحتويعلىالمركباتوعلاجالأمراضباستخدامهذهالمركبات.