公开(公告)号：DE69427361T2

公开(公告)日：2002-04-18

申请号：DE69427361

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT L ,  CHORGHADE S ,  WITTENBERGER J ,  BUNNELLE H ,  NARAYANAN A ,  SINGAM PULLA R ,  ESCH K ,  BEER O ,  WITZIG C ,  HERZIG C ,  RAO V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：DE69735710D1

公开(公告)日：2006-05-24

申请号：DE69735710

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD A ,  HUTCHINS W ,  JAE HWAN-SOO ,  TASKER S ,  VON GELDERN W ,  KESTER A ,  SORENSEN K ,  SZCZEPANKIEWICZ G ,  HENRY J ,  LIU GANG ,  WITTENBERGER J ,  KING A

IPC: C07D405/04 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/506 ,  A61K31/675 ,  A61P1/00 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D207/16 ,  C07D211/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D453/02 ,  C07D471/04 ,  C07D491/04 ,  C07F9/572 ,  C07F9/59

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：DE69735710T2

公开(公告)日：2007-03-29

申请号：DE69735710

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD A ,  HUTCHINS W ,  JAE HWAN-SOO ,  TASKER S ,  VON GELDERN W ,  KESTER A ,  SORENSEN K ,  SZCZEPANKIEWICZ G ,  HENRY J ,  LIU GANG ,  WITTENBERGER J ,  KING A

IPC: C07D405/04 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/506 ,  A61K31/675 ,  A61P1/00 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D207/16 ,  C07D211/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D453/02 ,  C07D471/04 ,  C07D491/04 ,  C07F9/572 ,  C07F9/59

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：DE69427361D1

公开(公告)日：2001-07-05

申请号：DE69427361

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT L ,  CHORGHADE S ,  WITTENBERGER J ,  BUNNELLE H ,  NARAYANAN A ,  SINGAM PULLA R ,  ESCH K ,  BEER O ,  WITZIG C ,  HERZIG C ,  RAO V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.