公开(公告)号：DE69427361T2

公开(公告)日：2002-04-18

申请号：DE69427361

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT L ,  CHORGHADE S ,  WITTENBERGER J ,  BUNNELLE H ,  NARAYANAN A ,  SINGAM PULLA R ,  ESCH K ,  BEER O ,  WITZIG C ,  HERZIG C ,  RAO V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：DE69427361D1

公开(公告)日：2001-07-05

申请号：DE69427361

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT L ,  CHORGHADE S ,  WITTENBERGER J ,  BUNNELLE H ,  NARAYANAN A ,  SINGAM PULLA R ,  ESCH K ,  BEER O ,  WITZIG C ,  HERZIG C ,  RAO V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.