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公开(公告)号：AT201681T
公开(公告)日：2001-06-15
申请号：AT94931741
申请日：1994-08-30
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT RICHARD L , CHORGHADE MUKUND S , WITTENBERGER STEVEN J , BUNNELLE WILLIAM H , NARAYANAN BIKSHANDAR A , SINGAM PULLA R , ESCH THOMAS K J , BEER DIETER O , WITZIG CHRISTIAN C , HERZIG THOMAS C , RAO ALLA V RAMA , TECHNOLOGY
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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公开(公告)号：CA2272539A1
公开(公告)日：1998-06-18
申请号：CA2272539
申请日：1997-12-12
Applicant: ABBOTT LAB
IPC: C07D317/60 , C07D405/04
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
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公开(公告)号：PT946537E
公开(公告)日：2005-08-31
申请号：PT97951641
申请日：1997-12-12
Applicant: ABBOTT LAB
IPC: C07D317/60 , C07D405/04
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公开(公告)号：DK0946537T3
公开(公告)日：2005-08-15
申请号：DK97951641
申请日：1997-12-12
Applicant: ABBOTT LAB
IPC: C07D317/60 , C07D405/04
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
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公开(公告)号：DK0717741T3
公开(公告)日：2001-08-20
申请号：DK94931741
申请日：1994-08-30
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT RICHARD L , CHORGHADE MUKUND S , WITTENBERGER STEVEN J , BUNNELLE WILLIAM H , NARAYANAN BIKSHANDAR A , SINGAM PULLA R , ESCH THOMAS K J , BEER DIETER O , WITZIG CHRISTIAN C , HERZIG THOMAS C , RAO ALLA V RAMA
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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Patent Agency Ranking
公开(公告)号：CA2272539C
公开(公告)日：2006-06-13
申请号：CA2272539
申请日：1997-12-12
Applicant: ABBOTT LAB
IPC: C07D317/60 , C07D405/04
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
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公开(公告)号：ES2242985T3
公开(公告)日：2005-11-16
申请号：ES97951641
申请日：1997-12-12
Applicant: ABBOTT LAB
IPC: C07D317/60 , C07D405/04
Abstract: LA PRESENTE INVENCION SE REFIERE A UNA REACCION DE ADICION DE MICHAEL ASIMETRICA QUE DAN NITROCETONADIASTEREOISOMERAS Y ESTEREOSELECTIVIDAD INCREMENTADA.
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公开(公告)号：DE69427361T2
公开(公告)日：2002-04-18
申请号：DE69427361
申请日：1994-08-30
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT L , CHORGHADE S , WITTENBERGER J , BUNNELLE H , NARAYANAN A , SINGAM PULLA R , ESCH K , BEER O , WITZIG C , HERZIG C , RAO V RAMA
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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9.发明专利
公开(公告)号：GR3036387T3
公开(公告)日：2001-11-30
申请号：GR20010401243
申请日：2001-08-14
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT RICHARD L , CHORGHADE MUKUND S , WITTENBERGER STEVEN J , BUNNELLE WILLIAM H , NARAYANAN BIKSHANDAR A , SINGAM PULLA R , ESCH THOMAS K J , BEER DIETER O , WITZIG CHRISTIAN C , HERZIG THOMAS C , RAO ALLA V RAMA
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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公开(公告)号：AT294789T
公开(公告)日：2005-05-15
申请号：AT97951641
申请日：1997-12-12
Applicant: ABBOTT LAB
IPC: C07D317/60 , C07D405/04
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
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