公开(公告)号：WO0119817A3

公开(公告)日：2002-01-17

申请号：PCT/US0025444

申请日：2000-09-14

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  LI YIHONG ,  DRIZIN IRENE ,  KINCAID JOHN F ,  BASHA ANWER ,  DONG LIMING ,  HAKEEM AHMED A

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/55 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P15/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/34 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14

Abstract: A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.

Abstract translation: 一系列3-吡咯烷氧基-3'-吡啶基醚化合物，使用这些化合物选择性控制哺乳动物中的神经递质释放的方法，以及包括这些化合物的药物组合物。 优选的化合物是3-吡咯烷基甲氧基-3' - （5'-和/或6'-取代的）吡啶基醚。

公开(公告)号：DE60128543T2

公开(公告)日：2008-01-31

申请号：DE60128543

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers.

公开(公告)号：ES2286105T3

公开(公告)日：2007-12-01

申请号：ES01910414

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: Un compuesto seleccionado del grupo que se compone de (a) un compuesto de la estructura o una sal del mismo farmacéuticamente admisible, en donde R1 es hidrógeno o metilo; R2 es hidrógeno; R5 es F, Cl o Br; y R6 es metilo, F, Cl o Br; (b) un compuesto de la estructura o una sal del mismo farmacéuticamente admisible, en donde R1 es hidrógeno o metilo; R2 es metilo; R5 es F, Cl o Br; y R6 es metilo, F, Cl o Br; (c) 5-[(S)-2-amino-1-propiloxi]-2-cloropiridina o una sal del mismo farmacéuticamente admisible; (d) ácido 5-[(R)-2-metilamino-1-propiloxi]-2-cloropiridina p-toluensulfónico; (e) 5-[(S)-2-amino-1-propiloxi]-2-fluoropiridina o una sal del mismo farmacéuticamente admisible; (f) ácido 5-[(R)-2-amino-1-propiloxi]-2-fluoropiridina p-toluensulfónico; (g) ácido 5-[(R)-2-metilamino-1-propiloxi]-2-fluoropiridina p-toluensulfónico; (h) ácido 5-[(R)-2-dimetilamino-1-propiloxi]-2-cloro-3-bromopiridina p-toluensulfónico; (i) ácido 5-[(S)-2-dimetilamino-1-propiloxi]-2-cloro-3-metilpiridina p-toluensulfónico; y (j) ácido 5-[(R)-2-dimetilamino-1-propiloxi]-2-cloro-3-metilpiridina p-toluensulfónico.

公开(公告)号：DE60128543D1

公开(公告)日：2007-07-05

申请号：DE60128543

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers.

公开(公告)号：CA2397798C

公开(公告)日：2011-01-04

申请号：CA2397798

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: The present invention is directed to a series of substituted pyridine compounds (I), a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers. n = 1-4, R1-R6 as in the claims.

公开(公告)号：MXPA02007498A

公开(公告)日：2003-01-28

申请号：MXPA02007498

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： DONG LIMING

IPC: A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04 ,  C07D213/65

Abstract: La presente invencion esta dirigida a una serie de compuestos de piridina substituida (1), un metodo para controlar selectivamente la liberacion de neurotransmisor en mamiferos utilizando estos compuestos, y composiciones farmaceuticas que contienen estos compuestos. Los compuestos preferidos son piridil eteres 3'-(5'-y/o 6'- substituidos). El valor de n es 1-4, R1-R6 son como se presenta en las reivindicaciones.

公开(公告)号：CA2381252A1

公开(公告)日：2001-03-22

申请号：CA2381252

申请日：2000-09-14

Applicant: ABBOTT LAB

Inventor： DRIZIN IRENE ,  LI YIHONG ,  KINCAID JOHN F ,  BASHA ANWER ,  HAKEEM AHMED A ,  LIN NAN-HORNG ,  DONG LIMING

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/55 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P15/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/34 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427

Abstract: A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.

公开(公告)号：AT362917T

公开(公告)日：2007-06-15

申请号：AT01910414

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers.

公开(公告)号：CA2397798A1

公开(公告)日：2001-08-09

申请号：CA2397798

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： DONG LIMING ,  LIN NAN-HORNG

IPC: A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04 ,  C07D213/65

Abstract: The present invention is directed to a series of substituted pyridine compounds (I), a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers. n = 1-4, R1-R6 as in the claims.