公开(公告)号：JP2009256360A

公开(公告)日：2009-11-05

申请号：JP2009148236

申请日：2009-06-23

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： LIN NAN-HORNG ,  HE YUN ,  HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO

IPC: C07D401/12 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: PROBLEM TO BE SOLVED: To provide a compound controlling synapse transmission in a neuron nicotinic cholinergic channel receptor, an intermediate for the synthesis of the compound, and a method for preparing a compound represented by formula (I) using the intermediate. SOLUTION: This compound is 5-(5,5-dimethyl-1,3-hexadienyl)-6-chloro-3-(2-(R)-pyrrolidinylmethoxy)pyridine or its pharmaceutically permissible salt in a 3-pyridyloxymethyl heterocyclic ether compound represented by formula (I). COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：提供控制神经元烟碱胆碱通道受体中的突触传递的化合物，用于合成化合物的中间体，以及使用该中间体制备由式（I）表示的化合物的方法。 解决方案：该化合物是5-（5,5-二甲基-1,3-己二烯基）-6-氯-3-（2-（R） - 吡咯烷基甲氧基）吡啶或其药学上允许的盐，在3-吡啶氧基甲基 由式（I）表示的杂环醚化合物。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：WO0218321A3

公开(公告)日：2003-04-10

申请号：PCT/US0126133

申请日：2001-08-21

Applicant: ABBOTT LAB

Inventor： LIU GANG ,  LI YIHONG ,  JANOWICK DAVID A ,  PEI ZHONGHUA

IPC: A61P3/10 ,  C07C233/56 ,  C07C259/06 ,  C07D207/26 ,  C07D207/27 ,  C07D209/14 ,  C07D209/48 ,  C07D211/26 ,  C07D211/96 ,  C07D213/74 ,  C07D215/12 ,  C07D215/14 ,  C07D277/74 ,  C07D295/13 ,  C07D295/26 ,  C07D307/68 ,  C07D307/91 ,  C07D319/18 ,  C07D333/20 ,  C07D405/06 ,  A61K31/194 ,  C07D295/12 ,  C07D295/22

CPC classification number: C07D207/27 ,  C07C233/56 ,  C07C259/06 ,  C07C2601/08 ,  C07D209/14 ,  C07D209/48 ,  C07D211/26 ,  C07D211/96 ,  C07D213/74 ,  C07D215/12 ,  C07D215/14 ,  C07D277/74 ,  C07D295/13 ,  C07D295/26 ,  C07D307/68 ,  C07D307/91 ,  C07D319/18 ,  C07D333/20 ,  C07D405/06

Abstract: Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.

Abstract translation: 式（I）化合物或其治疗上可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。

公开(公告)号：WO0119817A3

公开(公告)日：2002-01-17

申请号：PCT/US0025444

申请日：2000-09-14

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  LI YIHONG ,  DRIZIN IRENE ,  KINCAID JOHN F ,  BASHA ANWER ,  DONG LIMING ,  HAKEEM AHMED A

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/55 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P15/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/34 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14

Abstract: A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.

Abstract translation: 一系列3-吡咯烷氧基-3'-吡啶基醚化合物，使用这些化合物选择性控制哺乳动物中的神经递质释放的方法，以及包括这些化合物的药物组合物。 优选的化合物是3-吡咯烷基甲氧基-3' - （5'-和/或6'-取代的）吡啶基醚。

公开(公告)号：CA2315117C

公开(公告)日：2011-03-15

申请号：CA2315117

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  GARVEY DAVID S ,  RYTHER KEITH ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  HE YUN ,  WASICAK JAMES T ,  BAI HAO ,  DART MICHAEL J ,  EHRLICH PAUL P ,  LI YIHONG ,  KINCAID JOHN F ,  SCHKERYANTZ JEFFREY M ,  LYNCH JOHN K

IPC: C07D401/12 ,  A61K31/40 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：CA2256022C

公开(公告)日：2008-07-29

申请号：CA2256022

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HOLLADAY MARK W ,  RYTHER KEITH ,  BAI HAO ,  HE YUN ,  LI YIHONG

IPC: C07D409/14 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

公开(公告)号：DE69730229D1

公开(公告)日：2004-09-16

申请号：DE69730229

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  HOLLADAY W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.

公开(公告)号：CA2381252A1

公开(公告)日：2001-03-22

申请号：CA2381252

申请日：2000-09-14

Applicant: ABBOTT LAB

Inventor： DRIZIN IRENE ,  LI YIHONG ,  KINCAID JOHN F ,  BASHA ANWER ,  HAKEEM AHMED A ,  LIN NAN-HORNG ,  DONG LIMING

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/55 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P15/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/34 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427

Abstract: A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.

公开(公告)号：CA2315117A1

公开(公告)日：1999-07-01

申请号：CA2315117

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HE YUN ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  BAI HAO ,  DART MICHAEL J ,  WASICAK JAMES T ,  KINCAID JOHN F ,  GARVEY DAVID S ,  LI YIHONG ,  RYTHER KEITH ,  HOLLADAY MARK W ,  EHRLICH PAUL P ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  SCHKERYANTZ JEFFREY M ,  LYNCH JOHN K

IPC: A61K31/427 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/50 ,  A61K31/505

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceuticallyacceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：CA2285263C

公开(公告)日：2009-03-10

申请号：CA2285263

申请日：1998-04-10

Applicant: ABBOTT LAB

Inventor： DAANEN JEROME F ,  LI YIHONG ,  RYTHER KEITH B ,  HOLLADAY MARK W ,  ELLIOTT RICHARD L ,  LIN NAN-HORNG ,  WASICAK JAMES T ,  DART MICHAEL J ,  HE YUN

IPC: C07D491/048 ,  A61K31/4355 ,  A61K31/4365 ,  A61P25/00 ,  A61P43/00 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y1 , Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically- effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DK0934308T3

公开(公告)日：2004-12-06

申请号：DK97927830

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.