公开(公告)号：DK0717741T3

公开(公告)日：2001-08-20

申请号：DK94931741

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT RICHARD L ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：AT201681T

公开(公告)日：2001-06-15

申请号：AT94931741

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT RICHARD L ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA ,  TECHNOLOGY

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：GR3036387T3

公开(公告)日：2001-11-30

申请号：GR20010401243

申请日：2001-08-14

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT RICHARD L ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：PT717741E

公开(公告)日：2001-10-31

申请号：PT94931741

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  HE YUN ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：CA2167833A1

公开(公告)日：1995-03-16

申请号：CA2167833

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT RICHARD L ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically -pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.