公开(公告)号：WO0010998A3

公开(公告)日：2000-05-18

申请号：PCT/US9918229

申请日：1999-08-11

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K ,  ARMIGER YOEK-LIN ,  OR YAT SUN

IPC: C07D471/04 ,  C07D455/02 ,  A61K31/4375 ,  A61P31/04

CPC classification number: C07D471/04

Abstract: Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

Abstract translation: 具有式（I）的抗菌化合物及其药学上可接受的盐，酯和酰胺，以及含有这些化合物的药物组合物及其在治疗细菌感染中的用途。

公开(公告)号：CA1287445C

公开(公告)日：1991-08-06

申请号：CA500188

申请日：1986-01-23

Applicant: LULY JAY R ,  ABBOTT LAB

Inventor： LULY JAY R ,  ROSENBERG SAUL H ,  PLATTNER JACOB J ,  FUNG ANTHONY K

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/47 ,  A61K31/55 ,  A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07D233/64 ,  C07K5/04

Abstract: PEPTIDYLAMINODIOLS The invention relates to renin inhibiting compounds of the formula: wherein R10 is , , , or ; A is hydrogen or an N-protecting group; w is 0 or 1; B is hydrogen, hydroxy, NH, N-alkyl, loweralkyl or arylalkyl; with the proviso that when w is 1, B is NH and when w is 0, B is hydrogen, hydroxy, loweralkyl or arylalkyl; R1 is loweralkyl or lipophilic or aromatic or hydrophilic amino acid side chains; m is 1-3; n is 1-3; p is 1-3; q is 1-3; s is 1-3; t is 0-2; R2 is hydrogen or loweralkyl; R3 and R4 are independently selected from loweralkyl, lipophilic or aromatic amino acid side chains; R5 and R7 are independently selected from hydrogen or loweralkyl; and R6 is hydrogen, loweralkyl, vinyl, arylalkyl or wherein R8 is hydrogen or loweralkyl, X is 0, NH or S and R9 is hydrogen, loweralkyl or alkanoyl or XR9 together can be loweralkylsulfonyl, N3 or Cl.

公开(公告)号：CA1205474A

公开(公告)日：1986-06-03

申请号：CA431795

申请日：1983-07-05

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB J ,  FUNG ANTHONY K

IPC: C07D498/00 ,  C07C45/00 ,  C07C45/46 ,  C07C45/51 ,  C07C45/67 ,  C07C45/68 ,  C07C49/84 ,  C07D307/85 ,  C07D413/04 ,  C07D498/04

Abstract: BENZISOXAZOLE CARBOXYLIC ACIDS Described are compounds of the formula I wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula II wherein X' and Y' may be the same or different and are selected from hydrogen, loweralkyl, or halo, and Z' is hydrogen, loweralkyl, halo, hydroxy or loweralkoxy, or pharmaceutically acceptable salts thereof. The compounds possess diuretic activity.

公开(公告)号：MX9709416A

公开(公告)日：1998-07-31

申请号：MX9709416

申请日：1997-12-02

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K ,  LEE CHEUK M ,  PLATTNER JACOB J ,  MA ZHENKUN ,  WANG WEI-BO

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/505 ,  A61K31/519 ,  A61K31/529 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/16 ,  C07D495/16 ,  C07D519/00 ,  C07K5/06

Abstract: Compuestos antibacterianos que tienen la formula (I) y las sales, ésteres y amidas farmacéuticamente aceptables de los mismos, cuyos ejemplos preferidos seleccionados incluyen aquellos compuestos en donde A es =CR6-; R1 es cicloalquilo de desde tres hasta ocho átomos de carbono o fenilo sustituido; R2 se selecciona a partir del grupo que consiste de (a), (b), (c) y (d); R3 es halogeno; R4 es hidrogeno inferior, un cation farmacéuticamente aceptable, o un grupoéster de profármaco; R5 es hidrogeno, alquilo inferor, halo(alquilo inferior), o -NR13R14, y R6 es halogeno, alquilo inferior, o amino(alquilo inferior), así como composiciones farmacéuticas que contienen estos compuestos, y el uso de las mismas en el tratamiento de infecfciones bacterianas.

公开(公告)号：ZA8304805B

公开(公告)日：1985-02-27

申请号：ZA8304805

申请日：1983-06-30

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB JOHN ,  FUNG ANTHONY K

IPC: A61K20060101 ,  C07D20060101 ,  A61K ,  C07D

公开(公告)号：AU5477399A

公开(公告)日：2000-03-14

申请号：AU5477399

申请日：1999-08-11

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K ,  ARMIGER YOEK-LIN ,  OR YAT SUN

IPC: C07D471/04 ,  C07D471/00

公开(公告)号：PT98685A

公开(公告)日：1992-07-31

申请号：PT9868591

申请日：1991-08-14

Applicant: ABBOTT LAB

Inventor： ROSENBERG SAUL H ,  DENISSEN JON F ,  BAKER WILLIAM R ,  FUNG ANTHONY K ,  BOYD STEVEN A ,  STEIN HERMAN H ,  HUTCHINS CHARLES W

IPC: A61K31/495 ,  A61K31/535 ,  A61K38/55 ,  C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D451/06 ,  C07D451/14 ,  C07D ,  A61K

Abstract: A renin inhibiting compound of the formula: (I) wherein X is O, NH or S and G is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that the compound is not N-(3-(4-Morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-methoxymethoxy)piperidin-1-yl)carbonyl-2-phenyl)ethoxyhexanamido)-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanamide.

公开(公告)号：DE3373656D1

公开(公告)日：1987-10-22

申请号：DE3373656

申请日：1983-07-04

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB JOHN ,  FUNG ANTHONY K

IPC: C07D498/00 ,  C07C45/00 ,  C07C45/46 ,  C07C45/51 ,  C07C45/67 ,  C07C45/68 ,  C07C49/84 ,  C07D307/85 ,  C07D413/04 ,  C07D498/04 ,  A61K31/42

Abstract: Described are compounds of the formula wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula wherein X min and Y min may be the same or different and are selected from hydrogen, loweralkyl, or halo, and Z min is hydrogen, loweralkyl, halo, hydroxy or loweralkoxy, or pharmaceutically acceptable salts thereof. The compounds possess diuretic activity.

公开(公告)号：ZA834805B

公开(公告)日：1985-02-27

申请号：ZA834805

申请日：1983-06-30

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB JOHN ,  FUNG ANTHONY K

IPC: A61K20060101 ,  C07D20060101 ,  A61K ,  C07D