公开(公告)号：JP2002000267A

公开(公告)日：2002-01-08

申请号：JP2001120859

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide an antibody specifically bonding generally to hepatitis C virus(HCV), more particularly, a panel of a new hybridoma cell strain secreting a monoclonal antibody against HCV protein 33C and the use of the monoclonal antibody. SOLUTION: The present invention relates to a monoclonal antibody specifically bonding to HCV protein 33C and free from bonding potency to HCV protein C-100 and a core and to a hybridoma producing the monoclonal antibody and selected from the group consisting of A.T.C.C. deposit No. HB10594, HB10589, HB10607 and HB10600. It also relates to a method for the use of the monoclonal antibody e.g. for the detection of hepatitis C virus HCV 33C protein in a specimen and an assay kit containing the antibody.

公开(公告)号：JP2002012600A

公开(公告)日：2002-01-15

申请号：JP2001120871

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide a highly specific and novel monoclonal antibody available for detecting a hepatitis C virus protein. SOLUTION: A monoclonal antibody not binding to hepatitis C virus C-100 protein and hepatitis C virus 33C protein and specifically binding to hepatitis C virus core protein, a hybridoma yielding the monoclonal antibody, a method for using the monoclonal antibody and an assay kit containing the antibody are provided.

公开(公告)号：EP0556320A4

公开(公告)日：1994-11-23

申请号：EP92900907

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K15/00 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/70

CPC classification number: C07K16/109

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：EP0569537A4

公开(公告)日：1994-10-05

申请号：EP92906219

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C12N2770/24222

公开(公告)号：CA2095735C

公开(公告)日：2004-02-03

申请号：CA2095735

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/18

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C- 100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：AT167522T

公开(公告)日：1998-07-15

申请号：AT92906219

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/20

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：AU662517B2

公开(公告)日：1995-09-07

申请号：AU1362792

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12Q1/70 ,  C12N5/20 ,  G01N33/68

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：CA2101534C

公开(公告)日：2004-01-20

申请号：CA2101534

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/18

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：GR3018082T3

公开(公告)日：1996-02-29

申请号：GR950403200

申请日：1995-11-15

Applicant: ABBOTT LAB

Inventor： CHIN JADE ,  GIBADLO MARY S ,  ROBEY W GERARD

IPC: A61K39/21 ,  A61K38/00 ,  A61K39/395 ,  A61P31/12 ,  A61P37/00 ,  C07K16/10 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/569 ,  G01N33/577 ,  A61K39/42

Abstract: This invention provides monoclonal antibodies characterized as being specific for an epitope on a HIV glycoprotein having a molecular weight of about 120,000 daltons (gp120), which recognize a carbohydrate portion of gp120 localized in the region from about amino acid 301 to about amino acid 358. The antibodies are further capable of substantially neutralizing the activity of human immunodeficiency viruses. The invention also provides hybridomas which produce such antibodies.

公开(公告)号：CA2044741A1

公开(公告)日：1991-12-19

申请号：CA2044741

申请日：1991-06-17

Applicant: ABBOTT LAB

Inventor： CHIN JADE ,  ROBEY W GERARD ,  GIBADLO MARY S

IPC: A61K39/21 ,  A61K38/00 ,  A61K39/395 ,  A61P31/12 ,  A61P37/00 ,  C07K16/10 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/569 ,  G01N33/577

Abstract: This invention provides monoclonal antibodies characterized as being specific for an epitope on a HIV glycoprotein having a molecular weight of about 120,000 daltons (gp120), which recognize a carbohydrate portion of gp120 localized in the region from about amino acid 301 to about amino acid 358. The antibodies are further capable of substantially neutralizing the activity of human immunodeficiency viruses. The invention also provides hybridomas which produce such antibodies.