公开(公告)号：JP2002000267A

公开(公告)日：2002-01-08

申请号：JP2001120859

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide an antibody specifically bonding generally to hepatitis C virus(HCV), more particularly, a panel of a new hybridoma cell strain secreting a monoclonal antibody against HCV protein 33C and the use of the monoclonal antibody. SOLUTION: The present invention relates to a monoclonal antibody specifically bonding to HCV protein 33C and free from bonding potency to HCV protein C-100 and a core and to a hybridoma producing the monoclonal antibody and selected from the group consisting of A.T.C.C. deposit No. HB10594, HB10589, HB10607 and HB10600. It also relates to a method for the use of the monoclonal antibody e.g. for the detection of hepatitis C virus HCV 33C protein in a specimen and an assay kit containing the antibody.

公开(公告)号：JP2002012600A

公开(公告)日：2002-01-15

申请号：JP2001120871

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide a highly specific and novel monoclonal antibody available for detecting a hepatitis C virus protein. SOLUTION: A monoclonal antibody not binding to hepatitis C virus C-100 protein and hepatitis C virus 33C protein and specifically binding to hepatitis C virus core protein, a hybridoma yielding the monoclonal antibody, a method for using the monoclonal antibody and an assay kit containing the antibody are provided.

公开(公告)号：EP0603307A4

公开(公告)日：1995-01-18

申请号：EP92920089

申请日：1992-08-21

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON JILL E ,  DAILEY STEPHEN H ,  DESAI SURESH M ,  DEVARE SUSHIL G

IPC: C12Q1/70 ,  C07K7/00 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C07K16/00 ,  C07K16/10 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/569 ,  G01N33/576 ,  G01N33/577 ,  C07K13/00

CPC classification number: C07K14/005 ,  C07K16/109 ,  C07K2317/34 ,  C12N2770/24222 ,  G01N33/5767 ,  Y10S436/82

Abstract: Monoclonal antibodies which specifically bind to Hepatitis C Virus (HCV) E2/NS1 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits for assays which contain these monoclonal antibodies.

公开(公告)号：EP0556320A4

公开(公告)日：1994-11-23

申请号：EP92900907

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K15/00 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/70

CPC classification number: C07K16/109

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：EP0599913A4

公开(公告)日：1995-01-18

申请号：EP92917270

申请日：1992-08-21

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON JILL E ,  DAILEY STEPHEN H ,  DESAI SURESH M ,  DEVARE SUSHIL G

IPC: A61K39/395 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C07K16/00 ,  C07K16/10 ,  C07K19/00 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K13/00 ,  C12Q1/70

CPC classification number: C07K14/005 ,  C07K16/109 ,  C12N2770/24222

公开(公告)号：GR3030212T3

公开(公告)日：1999-08-31

申请号：GR990401297

申请日：1999-05-13

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K16/08 ,  C12Q1/70 ,  C12P21/02 ,  C12N5/00

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：CA2095735A1

公开(公告)日：1992-05-08

申请号：CA2095735

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/18

Abstract: 2095735 9208738 PCTABS00013 Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：CA2095735C

公开(公告)日：2004-02-03

申请号：CA2095735

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12N5/18

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C- 100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：DE69022578D1

公开(公告)日：1995-10-26

申请号：DE69022578

申请日：1990-12-22

Applicant: ABBOTT LAB

Inventor： LEUNG TAT ,  CASEY JAMES M ,  SARIN VIRENDER KUMAR ,  MEHTA SMRITI U ,  DEVARE SUSHIL G ,  LESNIEWSKI RICHARD R ,  DESAI SURESH M

IPC: C12Q1/70 ,  C07K7/00 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C07K16/00 ,  C07K16/10 ,  G01N33/569 ,  G01N33/576 ,  C07K14/00

公开(公告)号：DE68918497T2

公开(公告)日：1995-05-04

申请号：DE68918497

申请日：1989-05-03

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  HUNT JEFFREY C ,  DEVARE SUSHIL G

IPC: G01N33/569 ,  A61K39/395 ,  C07K16/10 ,  C12N5/20 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577