公开(公告)号：WO2009003074A8

公开(公告)日：2009-07-16

申请号：PCT/US2008068264

申请日：2008-06-26

Applicant: ABBOTT LAB ,  GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

Inventor： GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

IPC: C07K14/435

CPC classification number: C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.

Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

公开(公告)号：WO2008002956A3

公开(公告)日：2008-07-03

申请号：PCT/US2007072185

申请日：2007-06-27

Applicant: ABBOTT LAB ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

CPC classification number: C07D417/04 ,  C07D413/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.

Abstract translation: 本发明涉及选自化合物的式I化合物。 式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。

公开(公告)号：WO2009003074A9

公开(公告)日：2010-10-28

申请号：PCT/US2008068264

申请日：2008-06-26

Applicant: ABBOTT LAB ,  GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

Inventor： GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

IPC: C07K14/435

CPC classification number: C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.

Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

公开(公告)号：WO2009003074A2

公开(公告)日：2008-12-31

申请号：PCT/US2008068264

申请日：2008-06-26

Applicant: ABBOTT LAB ,  GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

Inventor： GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

IPC: C07K14/435

CPC classification number: C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.

Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

公开(公告)号：MX2008016336A

公开(公告)日：2009-01-16

申请号：MX2008016336

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  KOUHEN RACHID EL ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

Abstract: La invención se refiere a una serie de derivados de tiazolina y oxazolina, composiciones de los mismos, y métodos para tratar condiciones y trastornos utilizando dichos compuestos.

公开(公告)号：MX2008016338A

公开(公告)日：2009-01-16

申请号：MX2008016338

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  KOUHEN RACHID EL ,  LI JINHE

IPC: C07D207/34 ,  A61K31/402 ,  A61K31/56 ,  A61K31/58 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07J9/00

Abstract: La invención se refiere a una serie de derivados de pirrol substituido, composiciones que comprenden los mismos, y métodos para tratar condiciones o trastornos utilizando dichos compuestos y composiciones.

公开(公告)号：CA2659762A1

公开(公告)日：2008-01-03

申请号：CA2659762

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： GOPALAKRISHNAN SUJATHA ,  EL KOUHEN RACHID ,  SARRIS KATHY A ,  LI JINHE ,  MALYSZ JOHN ,  GUBBINS EARL J ,  GOPALAKRISHNAN MURALI ,  WANG YING ,  MICHMERHUIZEN MELISSA J ,  LYNCH CHRISTOPHER L ,  GFESSER GREGORY A ,  FAGHIH RAMIN

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are r egulated by the nicotinic acetylcholine receptors.

公开(公告)号：AU2007265116A1

公开(公告)日：2008-01-03

申请号：AU2007265116

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： GOPALAKRISHNAN SUJATHA ,  LI JINHE ,  GUBBINS EARL J ,  GOPALAKRISHNAN MURALI ,  GFESSER GREGORY A ,  FAGHIH RAMIN ,  MALYSZ JOHN ,  LYNCH CHRISTOPHER L ,  KOUHEN RACHID EL

IPC: C07D207/34 ,  A61K31/402 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：BRPI0712667A2

公开(公告)日：2012-09-04

申请号：BRPI0712667

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE

IPC: C07D207/34 ,  A61K31/402 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：ZA200808757B

公开(公告)日：2010-03-31

申请号：ZA200808757

申请日：2008-10-14

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.